2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. HSP
  4. SEW84

SEW84 is an inhibitor of the Aha1stimulated Hsp90 (ASH) ATPase activity. SEW84 inhibit ASH activity with an IC50 value of 0.3 μM. SEW84 can be used for the research of proteostatic disease.

For research use only. We do not sell to patients.

SEW84 Chemical Structure

SEW84 Chemical Structure

CAS No. : 259089-67-3

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Based on 1 publication(s) in Google Scholar

SEW84 Related Antibodies

Top Publications Citing Use of Products

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HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

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IC50 & Target

IC50: 0.3 μM (ASH); 1.3 μM (GR-dependent luciferase expression); 0.7 μM (AR-dependent luciferase expression)[1]
In Vitro

SEW84 (5 μM) shows complete inhibition of ASH activity with an IC50 value of 0.3 μM[1].
SEW84 inhibited the GR- and AR-dependent luciferase expression with IC50 values of 1.3 and 0.7 μM, respectively[1].
SEW84 (0-20 μM) inhibits the Hsp90-Dependent folding of firefly luciferase[1].
SEW84 (0, 3, 10, 30 μM; 24 h) specifically clears phosphorylated tau[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SEW84 Related Antibodies

Western Blot Analysis[1]

Cell Line: tau-0N4R-HeLa cells
Concentration: 0, 3, 10, 30 μM
Incubation Time: 24 h
Result: Reduced the expression of phospho-Tau.

Immunofluorescence[1]

Cell Line: RFP-tau-0N4R HEK cells
Concentration: 1, 10 μM
Incubation Time: 24 h
Result: Completely abrogated the aggregation of tau.

Cell Proliferation Assay[1]

Cell Line: LNCaP and 22Rv1 cells
Concentration: 0-100 μM
Incubation Time: 24 h
Result: Observed a synergistic decrease in LNcaP cell proliferation when combined 1 μM GA with 10 μM SEw84.
Molecular Weight

422.40

Formula

C19H14F4N4OS
CAS No.
SMILES

O=C(C1=CC=CN1C2=CC=C(C=C2)F)NNC(NC3=CC=CC(C(F)(F)F)=C3)=S
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SEW84 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SEW84259089-67-3SEW04784SEW 84SEW-84SEW 04784SEW-04784HSPHeat shock proteinsAha1stimulated Hsp90 (ASH)ATPaseproteostatic diseaseInhibitorinhibitorinhibit

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