Sodium lactate ringer's solution  (Synonyms: Lactated ringer's solution (LRS))

Sodium lactate ringer's solution (Lactated ringer's solution (LRS)) is an isotonic crystal intravenous injection and arthroscopic irrigation solution containing racemic sodium lactate and electrolytes such as sodium, potassium, calcium and chloride (130 mEq sodium/L, 274 mOsm/L), which can be used as a cell integrity protectant. Sodium lactate ringer's solution maintains the integrity of human meniscus cells, ensures that they retain normal cell morphology, membrane regularity, size and density, and does not alter the mRNA expression levels of α1 (I) procollagen, α1 (II) procollagen, aggrecan or HSP70. Sodium lactate ringer's solution can be applied to studies related to extracellular fluid deficiency and meniscus tears^[1][2][3].

Compared with isotonic sodium chloride solution, Sodium lactate ringer's solution (3-6 h) better maintains the integrity of primary human meniscus-derived cells, and the cell integrity scores after 3 h or 6 h of exposure are comparable to those of serum-free cell culture medium^[2].
Sodium lactate ringer's solution (3-6 h) does not induce statistically significant changes in the mRNA expression of α1 (I) procollagen, α1 (II) procollagen, aggrecan, or heat shock protein 70 in primary human meniscus-derived cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Liquid

Colorless to light yellow

[Sodium lactate ringer's solution]

Room temperature in continental US; may vary elsewhere.

Store at 4°C, do not freeze

• [1]. Shackford SR, et al. Hypertonic sodium lactate versus lactated ringer's solution for intravenous fluid therapy in operations on the abdominal aorta. Surgery. 1983;94(1):41-51.

  [2]. Shinjo H, et al. Effect of irrigation solutions for arthroscopic surgery on intraarticular tissue: comparison in human meniscus-derived primary cell culture between lactate Ringer's solution and saline solution. J Orthop Res. 2002;20(6):1305-1310.

  [3]. Kuze S, et al. Comparative study of intravenous administration of Ringer's lactate, Ringer's acetate and 5% glucose containing these Ringer's solutions in human being. J Anesth. 1990;4(2):155-161.