2. Signaling Pathways
  3. Apoptosis
  4. IAP
  5. cIAP-2 Isoform
  6. cIAP-2 Degrader

cIAP-2 Degrader

cIAP-2 Degraders (2):

Cat. No. Product Name Effect Purity
  • HY-151966
    TD1092
    		Degrader 99.49%
    TD1092 is a pan-IAP degrader, degrades cIAP1, cIAP2, and XIAP. TD1092 activates Caspase 3/7, and promotes cancer cells apoptosis via IAP degradation. TD1092 inhibits TNFα mediated NF-κB pathway and reduces the phosphorylation of IKK, IkBα, p65, and p38. TD1092 can act as PROTAC, and is used for cancer research.
  • HY-155294
    SM-122
    		Degrader
    SM-122 is a monovalent Smac mimetic targeting cellular inhibitor of apoptosis protein (cIAP)-1/2. SM-122 can induce cIAP-1/2 degradation and weakly induce apoptosis in tumor cells. SM-122 can be used for the research of cancer, such as breast cancer.