2. Signaling Pathways
  3. Immunology/Inflammation
  4. IRAK
  5. IRAK Ligand

IRAK Ligand

IRAK Isoform Comparison

IRAK Ligands (5):

Cat. No. Product Name Effect Purity
  • HY-183800
    JH-l-25-NH2
    		Ligand
    JH-l-25-NH2 is an IRAK1/4 inhibitor analog derived from JH-I-25 and serves as the IRAK4-binding moiety for synthesizing VHL-recruiting and CRBN-recruiting IRAK4 PROTAC degraders.
  • HY-172591
    IRAK4 ligand-13
    		Ligand
    IRAK4 ligand-13 is a IRAK4 ligand. IRAK4 ligand-13 is a ligand for Target Protein for PROTAC. IRAK4 ligand-13 can be used for synthesis of PROTACs, such as LZ-07 (HY-172591).
  • HY-172406
    MAPK-IN-4
    		Ligand
    MAPK-IN-4 (Compound c1) is an orally active anti-inflammatory agent. MAPK-IN-4 can inhibit the expression and release of pro-inflammatory cytokines IL-6 and TNF-α induced by LPS (HY-D1056). MAPK-IN-4 can bind to IRAK4 and exert its anti-inflammatory effect by inhibiting the MAPK pathway.
  • HY-174470
    IRAK4 ligand-14
    		Ligand
    IRAK4 ligand-14 is a ligand for IRAK4. IRAK4 ligand-14 can be used for synthesizing PROTACs such as APH02174 (HY-174455).
  • HY-181899
    IRAK3 ligand-3
    		Ligand
    IRAK3 ligand-3 is a IRAK3 (IRAK-M) ligand. As a Ligand for Target Protein for PROTAC, IRAK3 ligand-3 is used to develop and design degraders of PROTAC IRAK3, such as PROTAC IRAK3 degrader-2 (HY-181898). IRAK3 ligand-3 applies to the research of immune diseases.