IRAK Ligand

PROTAC IRAK4 ligand-1 is a synthetic ligand for interleukin-1 receptor-associated kinase 4 (IRAK4). PROTAC IRAK4 ligand-1 can be used in the synthesis of PROTAC IRAK4 degrader-1 (HY-129966).

IRAK4 ligand-16 is a IRAK4 ligand and can be used for the synthesis of PROTACs, such as PROTAC IRAK4 degrader-4 (HY-139315) and PROTAC IRAK4 degrader-6 (HY-139317).

JH-l-25-NH2 is an IRAK1/4 inhibitor analog derived from JH-I-25 and serves as the IRAK4-binding moiety for synthesizing VHL-recruiting and CRBN-recruiting IRAK4 PROTAC degraders.

IRAK4 ligand-12 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). IRAK4 ligand-12 can be used for the synthesis of KTX-951 (HY-148290).

IRAK4 ligand-13 is a IRAK4 ligand. IRAK4 ligand-13 is a ligand for Target Protein for PROTAC. IRAK4 ligand-13 can be used for synthesis of PROTACs, such as LZ-07 (HY-172591).

MAPK-IN-4 (Compound c1) is an orally active anti-inflammatory agent. MAPK-IN-4 can inhibit the expression and release of pro-inflammatory cytokines IL-6 and TNF-α induced by LPS (HY-D1056). MAPK-IN-4 can bind to IRAK4 and exert its anti-inflammatory effect by inhibiting the MAPK pathway.

IRAK4 ligand-14 is a ligand for IRAK4. IRAK4 ligand-14 can be used for synthesizing PROTACs such as APH02174 (HY-174455).

IRAK3 ligand-3 is a IRAK3 (IRAK-M) ligand. As a Ligand for Target Protein for PROTAC, IRAK3 ligand-3 is used to develop and design degraders of PROTAC IRAK3, such as PROTAC IRAK3 degrader-2 (HY-181898). IRAK3 ligand-3 applies to the research of immune diseases.