Leukotriene Receptor
Leukotriene Receptor (cys-LTs) are a family of potent bioactive lipids that act through two structurally divergent G protein-coupled receptors, termed the CysLT1 and CysLT2 receptors. The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Leukotriene Receptor is a member of the superfamily of G protein-coupled receptors and uses a phosphatidylinositol-calcium second messenger system. Activation of CysLT1 by LTD4 results in contraction and proliferation of smooth muscle, oedema, eosinophil migration and damage to the mucus layer in the lung. Leukotriene receptor antagonists, called LTRAs for short, are a class of oral medication that is non-steroidal. They may also be referred to as anti-inflammatory bronchoconstriction preventors. LTRAs work by blocking a chemical reaction that can lead to inflammation in the airways.
Leukotriene Receptor Isoform Specific Products
All Product Categories
-
Leukotriene Receptor Inhibitors
(62)
View all products
-
Leukotriene Receptor Agonists
(10)
View all products
-
Leukotriene Receptor Antagonists
(127)
View all products
-
Leukotriene Receptor Activators
(2)
View all products
-
Leukotriene Receptor Control
(1)
View all products
-
Leukotriene Receptor Substrate
(1)
View all products
-
Leukotriene Receptor Related Products (225)
Related Products (225)
-
Antibodies (1)
-
Leukotriene Receptor Isoform Comparison
-
LY203647
0 ImagesCat. No.: HY-120486CAS No.: 122009-61-4LY203647 is an orally active antagonist for leukotriene receptor LTD4 and LTE4. LY203647 can be used in research about asthma and other inflammation diseases.
-
RG-7152
0 ImagesCat. No.: HY-19109CAS No.: 107813-63-8RG-7152 is a tetrazolyl-substituted leukotriene D4 receptor antagonist that can induce peroxisomal β-oxidation and peroxisome bifunctional enzymes (PBEs) in hepatocytes in various animal models. It has been shown to significantly increase PBE levels and β-oxidation activity in rat and mouse liver homogenates, while smaller effects were observed in guinea pigs and monkeys and no effect in dogs. In vitro studies have also shown that it can induce PBEs comparable to clofibric acid, indicating its potential as a peroxisome proliferator.
-
MK-571 (Standard)
0 ImagesCat. No.: HY-19989RCAS No.: 115104-28-4Synonyms: L-660711 (Standard)MK-571 (Standard) is the analytical standard of MK-571 (HY-19989). This product is intended for research and analytical applications. MK-571 (L-660711) is an orally active, potent and selective competitive leukotriene D4 (LTD4) receptor antagonist, with Ki values of 0.22 and 2.1 nM in guinea pig and human lung membranes, respectively. MK-571 is also a MRP4 and ABCC1 (MRP1) inhibitor. MK-571 inhibits constitutive and antigen-stimulated S1P (sphingosine-1-phosphate) release.
-
Zafirlukast-d7
0 ImagesCat. No.: HY-17492SCAS No.: 1217174-18-9Zafirlukast-d7 is the deuterium labeled Zafirlukast. Zafirlukast (ICI 204219) is a potent orally active leukotriene D4 (LTD4) receptor antagonist. Zafirlukast shows anti-asthmatic, anti-inflammatory and anti-bacterial effects.
-
Ricinelaidic acid
0 ImagesRicinelaidic acid, a 12-hydroxy fatty acid，is a leukotriene B4 (LTB4) receptor antagonist with the Ki of 2 μM in porcine neutrophil membranes. Ricinelaidic acid inhibits chemotaxis and calcium flux induced by LTB4 in isolated human neutrophils (IC50=10 and 7 μM, respectively). Ricinelaidic acid inhibits bronchoconstriction induced by LTB4 in rats.
-
CGP-35949 sodium
0 ImagesCat. No.: HY-19041CAS No.: 111130-13-3CGP-35949 sodium is a LTD4 antagonist with phospholipase inhibitory activity. CGP-35949 sodium can be used for research of asthma.
-
LY290324
0 ImagesCat. No.: HY-120755CAS No.: 146554-87-2LY290324 is a potent and orally active leukotriene D4 (LTD4) antagonist. LY290324 reduces LTC4, LTD4 and LTE4 (HY-113465)-induced bronchospasm. LY290324 has the potential for the research of antigen-induced bronchospasm.
-
Zafirlukast-d6
0 ImagesCat. No.: HY-17492S3CAS No.: 1109278-84-3Synonyms: ICI 204219-d6Zafirlukast-d6 is deuterated labeled Zafirlukast (HY-17492). Zafirlukast (ICI 204219) is a potent orally active leukotriene D4 (LTD4) receptor antagonist. Zafirlukast shows anti-asthmatic, anti-inflammatory and anti-bacterial effects.
-
Darbufelone mesylate (Standard)
0 ImagesCat. No.: HY-101438ARCAS No.: 139340-56-0Synonyms: CI-1004 mesylate (Standard)Darbufelone (mesylate) (Standard) is the analytical standard of Darbufelone (mesylate) (HY-101438A). This product is intended for research and analytical applications. Darbufelone mesylate (CI-1004 mesylate) is a dual inhibitor of cellular PGF2α and LTB4 production. Darbufelone potently inhibits PGHS-2 (IC50 = 0.19 μM) but is much less potent with PGHS-1 (IC50= 20 μM).
-
ZK-158252
0 ImagesCat. No.: HY-122175CAS No.: 162362-36-9ZK-158252 is a leukotriene B4 type-2 receptor (BLT2) antagonist.
-
Maresin conjugates in tissue regeneration 1
0 ImagesCat. No.: HY-125408CAS No.: 1784701-61-6Synonyms: MCTR1Maresin conjugates in tissue regeneration 1 (MCTR1) is a potent cytokine of pro-resolving mediating maresin conjugates in tissue regeneration (MCTR), which reduces the inflammatory response and promotes tissue regeneration. Maresin conjugates in tissue regeneration 1 antagonize LTD4-stimulated vascular responses.
-
L-648051
0 ImagesCat. No.: HY-122149CAS No.: 91541-18-3L-648051 is a leukotriene D4 receptor (LTD4) antagonist. L-648051 plays an important role in arrhythmias.
-
LY 292728
0 ImagesCat. No.: HY-117706CAS No.: 153034-77-6LY 292728 is a potent leukotriene B4 (LTB4) receptor antagonist. LY 292728 binds to human neutrophils with a Ki of 0.47 nM and binds to guinea pig lung membranes with a Ki of 0.04 nM.
-
γ-Linolenic acid ethyl ester (Standard)
0 ImagesCat. No.: HY-108396RCAS No.: 31450-14-3Synonyms: Ethyl γ-linolenate (Standard)γ-Linolenic acid ethyl ester (Standard) is the analytical standard of γ-Linolenic acid ethyl ester (HY-108396). This product is intended for research and analytical applications. γ-Linolenic acid ethyl ester (Ethyl γ-linolenate) is a leukotriene B4 receptor 4 (LTB4) antagonist.
-
Leukotriene B4-d5
0 ImagesCat. No.: HY-107608S1Synonyms: LTB4-d5Leukotriene B4-d5 (LTB4-d5) is deuterium labeled Leukotriene B4. Leukotriene B4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases. Leukotriene B4 is also an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
-
RG-12525 (Standard)
0 ImagesCat. No.: HY-101676RCAS No.: 120128-20-3Synonyms: NID 525 (Standard)RG-12525 (Standard) is the analytical standard of RG-12525 (HY-101676). This product is intended for research and analytical applications. RG-12525 is a a specific, competitive and orally effective antagonist of the peptidoleukotrienes, LTC4, LTD4 and LTE4, inhibiting LTC4-, LTD4- and LTE4-inducd guinea pig parenchymal strips contractions, with IC50s of 2.6 nM, 2.5 nM and 7 nM, respectively; RG-12525 is also a peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonist with IC50 of appr 60 nM and a potent inhibitor of CYP3A4, with a Ki value of 0.5 μM.
-
LY306669
0 ImagesCat. No.: HY-117557CAS No.: 153227-04-4LY306669 is a potent and selective leukotriene B4 (LTB4) receptor antagonist that can be used for the research of lung injury.
-
Etalocib (Standard)
0 ImagesSynonyms: LY293111 (Standard); VML 295 (Standard)Etalocib (Standard) is the analytical standard of Etalocib. This product is intended for research and analytical applications. Etalocib (LY293111), an orally active leukotriene B4 receptor antagonist, inhibits the binding of [3H]LTB4, with a Ki of 25 nM. Etalocib (LY293111) prevents LTB4-induced calcium mobilization with an lC50 of 20 nM. Etalocib (LY293111) induces apoptosis.
-
NPC-18915 free base
0 ImagesCat. No.: HY-187551CAS No.: 179487-75-3NPC-18915 free base is a neutrophil activation inhibitor. NPC-18915 free base inhibits CD11b/CD18-mediated neutrophil adhesion. NPC-18915 free base induces shedding of L-selectin on the neutrophil surface, thereby reducing endothelial cell adhesion. NPC-18915 free base inhibits calcium ionophore-induced LTB4 synthesis in neutrophils. NPC-18915 free base reduces the severity of TNBS-induced acute and recurrent colitis in rat experiments. NPC-18915 free base can be used in studies related to colitis.
