Leukotriene Receptor
Leukotriene Receptor (cys-LTs) are a family of potent bioactive lipids that act through two structurally divergent G protein-coupled receptors, termed the CysLT1 and CysLT2 receptors. The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Leukotriene Receptor is a member of the superfamily of G protein-coupled receptors and uses a phosphatidylinositol-calcium second messenger system. Activation of CysLT1 by LTD4 results in contraction and proliferation of smooth muscle, oedema, eosinophil migration and damage to the mucus layer in the lung. Leukotriene receptor antagonists, called LTRAs for short, are a class of oral medication that is non-steroidal. They may also be referred to as anti-inflammatory bronchoconstriction preventors. LTRAs work by blocking a chemical reaction that can lead to inflammation in the airways.
Leukotriene Receptor Isoform Specific Products
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Leukotriene Receptor Inhibitors
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Leukotriene Receptor Agonists
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Leukotriene Receptor Antagonists
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Leukotriene Receptor Activators
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Leukotriene Receptor Control
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Leukotriene Receptor Substrate
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Leukotriene Receptor Related Products (225)
Related Products (225)
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Antibodies (1)
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Leukotriene Receptor Isoform Comparison
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CGP-33304 sodium
0 ImagesCat. No.: HY-117385CAS No.: 111130-14-4CGP-33304 sodium is an antagonist of the leukotriene receptor and an inhibitor of phospholipase A2. CGP-33304 sodium inhibits the accumulation of myocardial depressant factor (MDF) activity in plasma and prolongs survival time in a standardized traumatic shock model of rats. CGP-33304 sodium can be applied in the research of traumatic shock.
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A63162
0 ImagesCat. No.: HY-118848CAS No.: 111525-11-2A63162 is a specific 5-lipoxygenase (5-LOX) inhibitor. A63162 inhibits mitogen (PHA)-induced horse mononuclear cell (BMC) proliferation and inhibits Calcimycin (HY-N6687)-induced leukotriene LTB4 synthesis at the same concentration. A63162 can be used in the study of chronic obstructive pulmonary disease, arthritis and inflammatory bowel disease.
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11-Keto-beta-boswellic acid (Standard)
0 ImagesCat. No.: HY-N2056RCAS No.: 17019-92-0Synonyms: 11-Keto-β-boswellic acid (Standard)11-Keto-beta-boswellic acid (Standard) is the analytical standard of 11-?Keto-?beta-?boswellic acid. This product is intended for research and analytical applications. 11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production.
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H-Ala-pNA
0 ImagesCat. No.: HY-W612175CAS No.: 1668-13-9H-Ala-pNA is an L-amino acid p-nitroaniline (pNA) derivative and a specific substrate for leukotriene A4 hydrolase. The D-enantiomer of H-Ala-pNA shows no activity toward leukotriene A4 hydrolase. H-Ala-pNA can be catalytically hydrolyzed by leukotriene A4 hydrolase, and the p-nitroaniline produced during the reaction is monitored spectrophotometrically at 405 nm to enable quantitative detection of enzyme activity. H-Ala-pNA is used to evaluate the potency of inhibitors targeting the amidase activity of leukotriene A4 hydrolase.
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MK-886 (Standard)
0 ImagesCat. No.: HY-14166RCAS No.: 118414-82-7Synonyms: L 663536 (Standard)MK-886 (Standard) is the analytical standard of MK-886. This product is intended for research and analytical applications. MK-886 (L 663536) is a potent, cell-permeable and orally active FLAP (IC50 of 30 nM) and leukotriene biosynthesis (IC50s of 3 nM and 1.1 μM in intact leukocytes and human whole blood, respectively) inhibitor. MK-886 is also a non-competitive PPARα antagonist and can induce apoptosis.
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CP-96021 hydrochloride
0 ImagesCat. No.: HY-101731CAS No.: 167011-22-5CP-96021 hydrochloride is a balanced, combined, potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonist with Ki values of 34 nM and 37 nM, respectively.
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Tremulacin
0 ImagesCat. No.: HY-N11072CAS No.: 29836-40-6Tremulacin is a 5-LOX inhibitor. Tremulacin reduces the biosynthesis of LTB4 and slow-reacting substances of anaphylaxis. Tremulacin alleviates carrageenan-induced paw edema in rats, croton oil-induced ear edema in mice, and acetic acid-induced writhing response in mice. Tremulacin inhibits TNF-α-stimulated ROS production and MMP-1 expression, and promotes collagen secretion in human dermal fibroblasts. Tremulacin is investigated for studies on inflammation-related diseases.
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BRI-12349
0 ImagesCat. No.: HY-176920CAS No.: 920707-33-1
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CP-199330
0 ImagesCat. No.: HY-123571CAS No.: 158102-92-2CP-199330 is a potent and orally active cysteinyl LT1 receptor antagonist.
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LM-1484
0 ImagesCat. No.: HY-101686CAS No.: 197506-02-8LM-1484 is an antagonist of CysLT1 receptor and displays a higher affinity for 3H-LTC4 sites.
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RS-601
0 ImagesCat. No.: HY-U00072CAS No.: 207987-59-5RS-601 is a novel leukotriene D4 (LTD4)/thromboxane A2 (TxA2) dual receptor antagonist, with antiasthmatic activities.
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CysLT1 receptor antagonist-1
0 ImagesCat. No.: HY-165155CAS No.: 119515-00-3CysLT1 receptor antagonist-1 (Compound 4) is an antagonist for cysteinyl leukotriene receptor 1 (CysLT1R) with an IC50 of 3.9 μM. CysLT1 receptor antagonist-1 exhibits weak agonist activity against G-protein-coupled bile acid receptor 1 (GPBAR1) with an efficact of 23% at 10 μM. CysLT1 receptor antagonist-1 can be used for asthma and allergic diseases researchs.
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LTD4 antagonist 2
0 ImagesCat. No.: HY-168784CAS No.: 107813-86-5LTD4 antagonist 2 (compound 6) is a leukotriene D4 (LTD4) antagonist with an IC50 of 2.8 μM against cysteinyl leukotriene 1 receptor (CysLT1R). LTD4 antagonist 2 is also a G protein-coupled bile acid receptor 1 (GPBAR1) agonist and can be utilized in research related to colitis, metabolic syndromes, and other GPBAR1/CysLT1R-related diseases.
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β-Tocotrienol (Standard)
0 ImagesCat. No.: HY-108693RCAS No.: 490-23-3β-Tocotrienol (Standard) is the analytical standard of β-Tocotrienol. This product is intended for research and analytical applications. β-Tocotrienol is an isomer of vitamin E. β-Tocotrienol is a less potent antioxidant than α-tocotrienol. β-Tocotrienol can be found in the tocotrienol-rich fraction (TRF) of palm oil, which possesses anti-carcinogenic effects in vitro on human colon carcinoma and prostate cancer cells. β-Tocotrienol inhibits the growth of A549 (GI50 = 1.38 μM) and U87MG (GI50 = 2.53 μM) cells. β-Tocotrienol also induces apoptosis in cancer cells. β-Tocotrienol can inhibit PD-L1 expression and mitigates PD-L1-mediated immune suppression in vitro and in vivo.
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CP-96486
0 ImagesCat. No.: HY-100316CAS No.: 139401-45-9CP-96486 is a potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonist with Kis of 20 and 24 nM, respectively.
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Verlukast-d6
0 ImagesCat. No.: HY-76511SCAS No.: 153698-86-3Synonyms: MK-679-d6; L 668019-d6Verlukast-d6 is a deuterium labeled Verlukast. Verlukast is a potent, selective, and orally active antagonist of leukotriene receptor. Verlukast has the potential for the research of asthma.
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LY 170198
0 ImagesCat. No.: HY-108963CAS No.: 99682-33-4LY 170198 is a protein kinase C inhibitor and a LTD4 antagonist. LY 170198 is promising for research of tumor promotion, oncogene activation, protein phosphorylation, feedback mechanisms in signal transduction and cellular responses to growth factors.
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SR2640 hydrochloride (Standard)
0 ImagesCat. No.: HY-107610RCAS No.: 146662-42-2SR2640 hydrochloride (Standard) is the analytical standard of SR2640 (hydrochloride) (HY-107610). This product is intended for research and analytical applications. SR2640 (hydrochloride) is a potent and selective competitive leukotriene D4/leukotriene E4 antagonist. SR2640 can be used for researching the role of leukotrienes in human asthma.
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LTD4 antagonist 1
0 ImagesCat. No.: HY-U00359CAS No.: 136564-67-5LTD4 antagonist 1 is a potent, orally active antagonist of leukotriene D4 (LTD4) with a Ki of 0.57 nM.
