Ligands for E3 Ligase
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Ligands for E3 Ligase Related Products (106)
Related Products (106)
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β-Naphthoflavone
0 Imagesβ-Naphthoflavone is an exogenous aryl hydrocarbon receptor (AHR) ligand. β-Naphthoflavone can activate AHR to participate in various biological processes, including cell growth, differentiation, apoptosis, and metabolism. β-Naphthoflavone has antioxidant activity and can exert its antioxidant function by regulating the activity of antioxidant enzymes. β-Naphthoflavone is also a non-carcinogenic CYP1A inducer and can be used to study aristolochic acid (AAI) induced renal injury.
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BMS-986470
0 ImagesBMS-986470, a HbF-activating CRBN E3 ligase modulator (CELMoD), is an orally active dual molecular glue degrader targeting ZBTB7A and WIZ. BMS-986470 has potent γ-globin induction activity. BMS-986470 can be used for sickle cell disease (SCD) research.
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Adamantan-1-ylmethanamine
0 ImagesSynonyms: 1-Aminomethyladamantane
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E3 ligase Ligand 80
0 ImagesCat. No.: HY-W005799CAS No.: 939-69-5
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MN714
0 ImagesCat. No.: HY-156373Purity: 99.12%MN714 is a prodrug of MN551 (HY-156395) with enhanced cell permeability. MN714 specifically and covalently binds to SOCS2 within living cells, with an EC50 of 3.77 μM at 2 h and 2.52 μM at 8 h. MN714 serves as a chemical probe for investigating the biological mechanisms of the SOCS2 and CRL5 complex, and also functions as an E3 ligase linker for PROTAC development.
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(S,S,S)-AHPC-Boc
0 ImagesCat. No.: HY-123109ACAS No.: 1797406-74-6Synonyms: (S,S,S)-VH032-Boc(S,S,S)-AHPC-Boc is the isomer of (S,R,S)-AHPC-Boc (HY-123109), and can be used as an experimental control. (S,R,S)-AHPC-Boc (VH032-Boc) is a ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Boc is used in PROTAC technology.
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VHLL-BCN
0 ImagesCat. No.: HY-148880CAS No.: 2874203-49-1
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(S,R,S)-AHPC-Boc derivative 1
0 ImagesSynonyms: VH032-Boc derivative 1(S,R,S)-AHPC-Boc derivative 1 (VH032-Boc derivative 1) is a derivative of (S,R,S)-AHPC-Boc (HY-123109), which is applicable to research related to PROTAC synthesis.
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2-(2,6-Dioxopiperidin-3-yl)-4-iodoisoindoline-1,3-dione
0 Images2-(2,6-Dioxopiperidin-3-yl)-4-iodoisoindoline-1,3-dione is a derivative of Thalidomide with an iodine atom on the benzyl ring
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Lenalidomide-4-Br-7-fluoro
0 ImagesLenalidomide-4-Br-7-fluoro is a derivative of Lenalidomide with a flouride and bromide groups on the benzyl ring.
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1-(4-Pip-Ph)-DHP-dione
0 ImagesCat. No.: HY-W761300CAS No.: 2446913-96-6
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Thalidomide-1-Me,4-OH
0 ImagesThalidomide-1-Me,4-OH is a Thalidomide (HY-14658) analogue. Thalidomide-1-Me,4-OH contains an extra methyl group on the glutarimide moiety of thalidomide, which is known to abrogate its ability to bind the E3 ligase CRBN. Thalidomide is a ligand for E3 ligase, which ubiquitinylates proteins, thus committing their fate to proteolytic destruction.
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Thalidomide-CH2NH2 hydrochloride
0 ImagesThalidomide-CH2NH2 hydrochloride is a Thalidomide analogue featuring a primary amine, which is a versatile group which may participate in many reactions.
