2. PROTAC
  3. Ligands for E3 Ligase
  4. Thalidomide-CH2NH2 hydrochloride

Thalidomide-CH2NH2 hydrochloride is a Thalidomide analogue featuring a primary amine, which is a versatile group which may participate in many reactions.

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Thalidomide-CH2NH2 hydrochloride

Thalidomide-CH2NH2 hydrochloride Chemical Structure

CAS No. : 444287-40-5

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Thalidomide-CH2NH2 hydrochloride Related Antibodies

Top Publications Citing Use of Products

View All Ligands for E3 Ligase Isoform Specific Products:

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von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B

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Description

Thalidomide-CH2NH2 hydrochloride is a Thalidomide analogue featuring a primary amine, which is a versatile group which may participate in many reactions.

Molecular Weight

323.73

Formula

C14H14ClN3O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1NC(C(CC1)N2C(C3=CC=CC(CN)=C3C2=O)=O)=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (38.61 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0890 mL 15.4450 mL 30.8899 mL
5 mM 0.6178 mL 3.0890 mL 6.1780 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0890 mL 15.4450 mL 30.8899 mL 77.2248 mL
5 mM 0.6178 mL 3.0890 mL 6.1780 mL 15.4450 mL
10 mM 0.3089 mL 1.5445 mL 3.0890 mL 7.7225 mL
15 mM 0.2059 mL 1.0297 mL 2.0593 mL 5.1483 mL
20 mM 0.1544 mL 0.7722 mL 1.5445 mL 3.8612 mL
25 mM 0.1236 mL 0.6178 mL 1.2356 mL 3.0890 mL
30 mM 0.1030 mL 0.5148 mL 1.0297 mL 2.5742 mL
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Thalidomide-CH2NH2 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thalidomide-CH2NH2444287-40-5Ligands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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