Lipase
Lipase is a water-soluble enzyme that can catalyze the ester bond hydrolysis of lipids, decompose and metabolize fat molecules. Lipase is produced primarily by the pancreas and helps the body digest fats and oils. Lipase inhibitors are able to reduce the digestion and absorption of fat, thereby reducing collective caloric intake and weight loss. Lipase inhibitors are commonly used to suppress diseases such as obesity, hyperlipidemia, and pancreatitis.
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Lipase Related Products (126)
Related Products (126)
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Antibodies (6)
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KT195
0 ImagesCat. No.: HY-18542CAS No.: 1402612-58-1KT195 is a serine hydrolase inhibitor that targets ABHD6 (IC50 = 10 nM) and ABHD2, with no significant activity against DAGLβ. KT195 inhibits endoplasmic reticulum calcium release and mitochondrial calcium uptake by targeting ABHD2, thereby blocking A23187 (HY-N6687) and H2O2-induced necrotic cell death and apoptosis. By inhibiting ABHD6 activity, KT195 significantly induces 2-AG accumulation in Neuro2A cells and reduces IL-1β secretion in lipopolysaccharide-treated macrophages. KT195 has been used as a negative control probe for DAGLβ and can be applied in studies of ABHD6 and ABHD2 in calcium signaling, lipid metabolism, neuronal function, and inflammatory.
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Sclerodione
0 ImagesCat. No.: HY-N12893CAS No.: 104855-19-8Sclerodione is a metabolite that can be produced by the Scleroderris canker fungus, Gremmeniellaabietina. Sclerodione has antifungal activity. Sclerodione is a lipase inhibitor (IC50: 1 μM).
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BemPPOX
0 ImagesCat. No.: HY-114754CAS No.: 1998101-23-7BemPPOX is an orally active, potent dog gastric lipase (DGL) inhibitor with Xl50 (the inhibitor molar excess leading to 50% lipase inhibition) of 0.5. BemPPOX is also a good inhibitor of GPLRP2 (xl50=0.64). BemPPOX efficiently regulates the gastrointestinal lipolysis and slows down the overall lipolysis process in rats. BemPPOX has the potential for obesity research.
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Fucoxanthinol
0 ImagesFucoxanthinol, a carotenoid, is a deacetylated Fucoxanthin (HY-N2302) metabolite with oral activity, and inhibits rat pancreatic lipase with an IC50 of 764 nM. Fucoxanthinol reduces expression of Bcl-2, Bcl-xL, survivin, XIAP, cIAP2, cyclin D1, cyclin D2, cyclin E, CDK4, CDK6, β-catenin, JunD, PPARγ, and induces GADD45α expression. Fucoxanthinol activates caspase-3, caspase-8, caspase-9, Nrf2/Keap1/ARE pathway, and inhibits activation of Akt, NF-κB, AP-1, PDPK1, GSK3β phosphorylation. Fucoxanthinol induces apoptosis, G0/G1 cell cycle arrest, inhibits cancer cell viability, proliferation, migration, invasiveness, tumour growth, adipocyte differentiation, oxidative stress, neurotoxicity, triglyceride absorption, angiogenesis, and obesity-induced inflammation. Fucoxanthinol can be used for the research of osteosarcoma, leukemia, lymphoma, adult T-cell leukemia, prostate cancer, colon cancer, breast cancer, hypertriglyceridaemia, Alzheimer’s disease, Parkinson’s disease, obesity, insulin resistance, malignant melanoma, and type II diabetes.
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Vulgarin
0 ImagesVulgarin is an orally active, naturally occurring eudesmane sesquiterpene with multiple biological activities including anti-inflammatory and antioxidant properties. Vulgarin targets and inhibits HMGB1, NF-κB and iNOS, while regulating key genes involved in hepatic gluconeogenesis; it also blocks inflammatory signaling pathways and inhibits the production and release of pro-inflammatory cytokines such as TNF-α and IL-1β. Vulgarin effectively alleviates pancreatic oxidative stress by reducing lipid peroxidation levels and restoring antioxidant enzyme activity. Vulgarin reverses abnormally elevated serum pancreatic enzyme levels, preserves the integrity of pancreatic acinar cells, and reduces pancreatic edema, hemorrhage and inflammatory infiltration. Vulgarin remodels the function of pancreatic endocrine cells, restores insulin content in β cells, and downregulates glucagon levels in α cells and somatostatin levels in δ cells. Vulgarin can be used in studies related to pancreatic injury and diabetes.
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(2S)-5,7,3',5'-Tetrahydroxyflavanone
0 ImagesCat. No.: HY-N7163CAS No.: 160436-10-2Synonyms: (2S)-3',5,5'7-Tetrahydroxyflavanone
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Aspulvinone H
0 ImagesCat. No.: HY-N14093CAS No.: 57744-69-1Aspulvinone H is an orally active inhibitor of AChE, pancreatic lipase, glutamic-oxaloacetic transaminase 1, and α-glucosidase, with IC50 values of 25.95 μM, 47.06 μM, 5.91/6.91 μM, and 4.6 μM, respectively. It has a Ka of 2.14 μM against GOT1 and a Ki of 6.58 μM against α-glucosidase. Aspulvinone H inhibits cancer cell proliferation, interferes with glutamine metabolism, elevates ROS levels, and induces cell apoptosis and S-phase arrest. Aspulvinone H exhibits antibacterial activity against Staphylococcus aureus. Aspulvinone H inhibits the growth of pancreatic ductal adenocarcinoma xenografts. Aspulvinone H reduces postprandial blood glucose in mice. Aspulvinone H can be used in research related to pancreatic ductal adenocarcinoma, diabetes, and Staphylococcus aureus infection.
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Lipase Substrate
0 ImagesSynonyms: DGGR; 1,2-o-Dilauryl-rac-glycero-3-glutaric acid (6′-methylresorufin) esterLipase Substrate is a chromogenic substrate of lipase to detect activity. It is used in colorimetric methods to measure lipase activity. It produces a red-purple compound, methylresorufin, upon digestion by the lipase enzyme.
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4'-O-Methylcatechin
0 ImagesCat. No.: HY-W740798CAS No.: 69912-75-04'-O-Methylcatechin acts as a lipase and acetylcholinesterase inhibitor, with an IC50 of 149.93 μM against lipase and an IC50 of 230.89 μM against electric eel-derived acetylcholinesterase. 4'-O-Methylcatechin possesses free radical scavenging activity and can be used in studies on antioxidation, antilipase activity and dementia.
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Ligupurpuroside A
0 ImagesCat. No.: HY-N2087CAS No.: 147396-01-8Ligupurpuroside A is an active product that can be extracted from Ligustrum robustum. Ligupurpuroside A acts as a natural inhibitor of lipase in a competitive manner.
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Panclicin A
0 ImagesCat. No.: HY-N14641CAS No.: 160669-37-4Panclicin A is a potent pancreatic lipase inhibitor.
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Panclicin C
0 ImagesCat. No.: HY-N14643CAS No.: 160669-43-2Panclicin C is a potent pancreatic lipase inhibitor.
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Escin IB (Standard)
0 ImagesCat. No.: HY-N0555RCAS No.: 26339-90-2Escin IB (Standard) is the analytical standard of Escin IB. This product is intended for research and analytical applications. Escin IB is a saponin isolated from skin and the endosperm of seeds of horse chestnut (Aesculus hippocastanum). Escin IB shows inhibitory effect on pancreatic lipase activity.
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Panclicin E
0 ImagesCat. No.: HY-N14647CAS No.: 160669-45-4Panclicin E is a potent pancreatic lipase inhibitor.
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hPL-IN-1
0 ImagesCat. No.: HY-155836CAS No.: 2387374-26-5hPL-IN-1 (compound 2t) is a reversible inhibitor of pancreatic lipase (PL) (IC50=1.86 μM) for anti-obesity research.
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Tridocosahexaenoin
0 ImagesCat. No.: HY-N7862CAS No.: 11094-59-0Tridocosahexaenoin is a homogeneous triglyceride that binds to the gastric lipase of the Pacific walrus (PWGL).
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BAY 59-9435 (Standard)
0 ImagesCat. No.: HY-102056RCAS No.: 654059-21-9BAY 59-9435 (Standard) is the analytical standard of BAY 59-9435 (HY-102056). This product is intended for research and analytical applications. BAY 59-9435 is a potent and selective inhibitor of Hormone Sensitive Lipase (HSL), with an IC50 of 0.023 μM.
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Panclicin D
0 ImagesCat. No.: HY-N14646CAS No.: 160669-44-3Panclicin D is a potent pancreatic lipase inhibitor.
