2. Signaling Pathways
  3. Apoptosis
  4. MDM-2/p53
  5. MDM-2/p53 Ligand

MDM-2/p53 Ligand

MDM-2/p53 Ligands (6):

Cat. No. Product Name Effect Purity
  • HY-130684
    MDM2 ligand 5
    		Ligand 98.02%
    MDM2 ligand 5 is a Ligand for E3 Ligase that can be used for the synthesis of PROTACs.
  • HY-W237439
    SEN205A
    		Ligand
    SEN205A is a fragment compound that binds to the hydrophobic pocket of human S100B (Kd=0.5-1.0 mM), which is the key region for the interaction of S100B with TRTK-12 and p53, and SEN205A can be displaced from this site by TRTK-12. SEN205A exhibits excellent in vitro ADME properties, including high metabolic stability, chemical stability, and good solubility under physiological pH conditions. SEN205A can serve as a starting fragment for structure-based optimization to develop inhibitors targeting the S100B-p53 protein-protein interaction and investigate the pathogenesis of malignant melanoma.
  • HY-P11255
    SPDI-48-T1
    		Ligand
    SPDI-48-T1 is a lysine-stapled peptide. SPDI-48-T1 exhibits discernible binding affinities for MDM2 and MDMX, with Kd values of 396 nM and 456 nM, respectively. SPDI-48-T1 exhibits anticancer activity against breast cancer, colorectal cancer, non-small cell lung cancer, cervical cancer, and malignant melanoma.
  • HY-180619
    p53 Y220C ligand-1
    		Ligand
    p53 Y220C ligand-1(compound PK-A) is a target protein ligand of p53 DUBTAC modulator-1 (HY-180618). p53 Y220C ligand-1 exhibits potent activity in inhibiting cell proliferation in Huh7 cells.
  • HY-170452
    MDM2 ligand 4
    		Ligand
    MDM2 ligand 4 is the ligand for MDM2 that can be used for synthesis of PROTAC degrader KT-253 (HY-170451).
  • HY-186051
    Rezatapopt analog-2
    		Ligand
    Rezatapopt analog-2 (compound A-15) is an analog of Rezatapopt (HY-156633) and can bind to P53.