country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-157830

Copy Link Print Information

MDM2 ligand 6

MDM2 ligand 6 is an MDM2 ligand that can be used in PROTAC synthesis-related research. MDM2 ligand 6 can serve as the target protein ligand moiety of the MDM2/GSPT1 PROTAC degrader WB156 (HY-174266).

For research use only. We do not sell to patients.

CAS No.: 870120-63-1
Formula: C₃₂H₃₆Cl₂N₄O₂
Molecular Weight:579.56

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

MDM2 ligand 6 Chemical Structure

CAS No.: 870120-63-1

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

MDM2

GSPT1

In Vitro

MDM2 ligand 6 (compound (4S, 5R)-1) serves as the target protein ligand moiety of WB156 (HY-174266), a dual MDM2 and GSPT1 PROTAC degrader with a DC₅₀ of 23 nM for MDM2, and is applicable for leukemia-related research^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Chemical Information

CAS No. 870120-63-1
Molecular Weight 579.56
Formula C₃₂H₃₆Cl₂N₄O₂
SMILES

O=C(N1CCNCC1)N2[C@H](C3=CC=C(C=C3)Cl)[C@H](C4=CC=C(C=C4)Cl)N=C2C5=C(C=C(C=C5)C(C)(C)C)OCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang B, et al. Development of selective small molecule MDM2 degraders based on nutlin. European journal of medicinal chemistry. 2019 Aug 15;176:476-491. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote