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Referencia número: HY-157830

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MDM2 ligand 6

MDM2 ligand 6 is an MDM2 ligand that can be used in PROTAC synthesis-related research. MDM2 ligand 6 can serve as the target protein ligand moiety of the MDM2/GSPT1 PROTAC degrader WB156 (HY-174266).

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No. CAS: 870120-63-1
Fòrmula: C₃₂H₃₆Cl₂N₄O₂
Peso molecular:579.56

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

MDM2 ligand 6 Chemical Structure

No. CAS: 870120-63-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

IC₅₀ & Target

MDM2

GSPT1

In Vitro

MDM2 ligand 6 (compound (4S, 5R)-1) serves as the target protein ligand moiety of WB156 (HY-174266), a dual MDM2 and GSPT1 PROTAC degrader with a DC₅₀ of 23 nM for MDM2, and is applicable for leukemia-related research^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 870120-63-1
Peso molecular 579.56
Fòrmula C₃₂H₃₆Cl₂N₄O₂
SMILES

O=C(N1CCNCC1)N2[C@H](C3=CC=C(C=C3)Cl)[C@H](C4=CC=C(C=C4)Cl)N=C2C5=C(C=C(C=C5)C(C)(C)C)OCC
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Wang B, et al. Development of selective small molecule MDM2 degraders based on nutlin. European journal of medicinal chemistry. 2019 Aug 15;176:476-491. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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