WB156
WB156 is a dual MDM2 and GSPT1 degrader. WB156 can recruit CRBN (Cereblon, a substrate receptor of the E3 ubiquitin-ligase complex) to induce the ubiquitination-proteasome pathway-mediated degradation of MDM2 and GSPT1. WB156 is promising for research of cancers, such as leukemia.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 2368944-44-7
- Fòrmula: C48H48Cl2N6O5
- Peso molecular:859.84
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Ver todos los productos específicos de isoformas PROTACs
MoreVer todos los productos específicos de isoformas Eukaryotic Release Factor (eRF)
More
Actividad biológica
|
MDM2 |
eRF3a/GSPT1 |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| RS4-11 | IC50 |
3.2 nM
Compound: 32
|
Antiproliferative activity against human RS4:11 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human RS4:11 cells assessed as reduction in cell viability after 48 hrs by MTT assay
|
[PMID: 31128449] |
Chemical Information
-
No. CAS 2368944-44-7
-
Peso molecular 859.84
-
Fòrmula C48H48Cl2N6O5
-
SMILES
O=C(N1CCN(CC1)CC#CC2=C3C(C(N(C4C(NC(CC4)=O)=O)C3)=O)=CC=C2)N5[C@H](C6=CC=C(C=C6)Cl)[C@H](C7=CC=C(C=C7)Cl)N=C5C8=C(C=C(C=C8)C(C)(C)C)OCC
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
WB156 Related Classifications
HY-174266 Related Classifications
Powered by Bioz