NADPH Oxidase
NOX
NADPH-oxidase (NOX) is a highly regulated dynamic complex comprising membrane and cytosolic proteins and is the major source of nonmitochondrial cellular reactive oxygen species (ROS). The ROS generated by NADPH oxidases have crucial roles in various physiological processes, including innate immunity, modulation of redox-dependent signalling cascades, and as cofactors in the production of hormones.
NOX enzymes are a family of transmembrane proteins comprising seven members (NOX1-NOX5 and DUOX1 and DUOX2), each with a specific tissue distribution and activation mechanism. They catalyze the reduction of molecular oxygen to superoxide anion, which in turn reacts quickly to generate other ROS, such as hydrogen peroxide. Although basic NOX activity is crucial for normal physiology, overshooting activity of NOX enzymes leads to disease. NADPH oxidases are increasingly recognized as interesting drug targets.
NADPH Oxidase Isoform Specific Products
All Product Categories
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NADPH Oxidase Related Products (105)
Related Products (105)
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Antibodies (3)
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NADPH Oxidase Isoform Comparison
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GKT136901 (Standard)
0 ImagesGKT136901 (Standard) is the analytical standard of GKT136901. This product is intended for research and analytical applications. GKT136901 is a potent, selective and orally active inhibitor of NADPH oxidase (NOX1/4), with Kis of 160 and 165 nM, respectively. GKT136901 is also a selective and direct scavenger of peroxynitrite. GKT136901 can be used for the research of diabetic nephropathy, stroke, and neurodegeneration. GKT136901 also has anti-inflammatory activity.
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VJ115
0 ImagesCat. No.: HY-111089CAS No.: 929256-79-1VJ115 is a potent ENOX1 inhibitor with an EC50 of 50 μM. By inhibiting ENOX1, VJ115 elevates NADH, which in turn downregulates the phosphorylation of p70S6K1/S6, alters the expression of c-Jun and cytoskeletal proteins, induces endothelial cells to lose polarization and migration ability, and increases caspase-3-dependent apoptosis under radiation. VJ115 can be used in studies related to solid tumors.
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6-Aminonicotinamide (Standard)
0 Images6-Aminonicotinamide, a potent antimetabolite of nicotinamide, is competitive NADP+-dependent enzyme glucose-6-phosphate dehydrogenase (G6PD) inhibitor (Ki=0.46 μM). 6-Aminonicotinamide resultis ATP depletion and synergizes with DNA-crosslinking chemotherapy agents, such as Cisplatin (HY-17394), in killing cancer cells.
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Setanaxib (Standard)
0 ImagesSynonyms: GKT137831 (Standard); GKT831 (Standard)Setanaxib (Standard) is the analytical standard of Setanaxib. This product is intended for research and analytical applications. Setanaxib (GKT137831) is a selective NADPH oxidase (NOX1/4) inhibitor with Kis of 140 and 110 nM, respectively.
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VAS 3947 (Standard)
0 ImagesCat. No.: HY-111447RCAS No.: 869853-70-3VAS 3947 (Standard) is the analytical standard of VAS 3947 (HY-111447). This product is intended for research and analytical applications. VAS 3947, a specific NADPH oxidase (NOX) inhibitor, exerts a potent antiplatelet effect. VAS3947 induces apoptosis independently of anti-NOX activity, via UPR activation, mainly due to aggregation and misfolding of proteins.
