Nucleoside Antimetabolite/Analog
Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.
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Nucleoside Antimetabolite/Analog Related Products (2437)
Related Products (2437)
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N4-Benzoyl-2'-deoxy-5'-O-DMT-2',2'-difluorocytidine
0 ImagesCat. No.: HY-154221CAS No.: 142808-43-3N4-Benzoyl-2'-deoxy-5'-O-DMT-2',2'-difluorocytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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2'-Deoxyadenosine-15N5,d13
0 ImagesCat. No.: HY-W040329S32'-Deoxyadenosine-15N5,d13 is deuterium and 15N labeled 2'-Deoxyadenosine (HY-W040329). 2′-Deoxyadenosine is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine inhibits the growth of various cells. 2'-Deoxyadenosine has an anticancer effect on colon cancer.
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5’-O-(4,4’-Dimethoxytrityl)-3’-O-methyluridine
0 ImagesCat. No.: HY-154466CAS No.: 127212-40-2
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3′-Phenylcarbamate-UTP
0 ImagesCat. No.: HY-155757CAS No.: 401619-08-73′-Phenylcarbamate-UTP is phenylcarbamate (Phenylcarbamate) modified uridine triphosphate (UTP).
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Uridine-13C,15N2
0 ImagesCat. No.: HY-B1449S9CAS No.: 369656-75-7Synonyms: β-Uridine-13C,15N2
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2’-O-Methyl-N2,N2-dimethyl-guanosine
0 ImagesCat. No.: HY-152706CAS No.: 113886-73-02’-O-Methyl-N2,N2-dimethyl-guanosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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1,2-Di-O-acetyl-3-azido-3-deoxy-5-O-(4-methyl) benzoyl-L-ribofuranose
0 ImagesCat. No.: HY-1543101,2-Di-O-acetyl-3-azido-3-deoxy-5-O-(4-methyl) benzoyl-L-ribofuranose is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 1,2-Di-O-acetyl-3-azido-3-deoxy-5-O-(4-methyl) benzoyl-L-ribofuranose is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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N2-iso-Butyroyl-3’-O-methylguanosine
0 ImagesCat. No.: HY-154482CAS No.: 160107-07-3N2-iso-Butyroyl-3’-O-methylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7).
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2'-Deoxy-2'-fluoroadenosine-5'-O-triphosphate
0 ImagesCat. No.: HY-134033CAS No.: 73449-07-7Synonyms: 2'-Fluoro dATP2'-Deoxy-2'-fluoroadenosine-5'-O-triphosphate (2'-Fluoro dATP) is a monomeric raw material that can be used for nucleic acid synthesis.
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N6-Benzoyl-9-β-D-arabinofuranosyladenine
0 ImagesN6-Benzoyl-9-β-D-arabinofuranosyladenine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
![N3-[(Pyrid-4-yl)methyl]uridine](https://file.medchemexpress.com/product_pic/hy-154737.gif "Click to View N3-[(Pyrid-4-yl)methyl]uridine Product Detail")
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2-Deoxy-2’-fluoroisocytidine
0 ImagesCat. No.: HY-154717CAS No.: 1668560-65-32-Deoxy-2’-fluoroisocytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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8-Allyloxyguanosine
0 ImagesCat. No.: HY-152546CAS No.: 126138-81-68-Allyloxyguanosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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5’-O-DMTr-2’-OMeU-methyl phosphonamidite
0 ImagesCat. No.: HY-154081CAS No.: 191786-64-85’-O-DMTr-2’-OMeU-methyl phosphonamidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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2’-Deoxy-2’-fluoro-N3-(2S)-(2-amino-3-carbonyl] propyl-beta-D-arabinouridine
![2’-Deoxy-2’-fluoro-N3-(2S)-(2-amino-3-carbonyl] propyl-beta-D-arabinouridine](https://file.medchemexpress.com/product_pic/hy-154662.gif "Click to View 2’-Deoxy-2’-fluoro-N3-(2S)-(2-amino-3-carbonyl] propyl-beta-D-arabinouridine Product Detail")
0 ImagesCat. No.: HY-154662CAS No.: 2072145-25-42’-Deoxy-2’-fluoro-N3-(2S)-(2-amino-3-carbonyl] propyl-beta-D-arabinouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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5’(R)-C-Methyl-2-thiouridine
0 ImagesCat. No.: HY-152561CAS No.: 2305416-01-55’(R)-C-Methyl-2-thiouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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Deoxycytidine triphosphate-13C9 dilithium
0 ImagesCat. No.: HY-101400S4Synonyms: dCTP-13C9 dilithium; 2′-Deoxycytidine-5′-triphosphate-13C9 dilithiumDeoxycytidine triphosphate-13C9 (dCTP-13C9 dilithium; 2′-Deoxycytidine-5′-triphosphate-13C9) dilithium is 13C-labeled Deoxycytidine triphosphate (HY-101400). Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.
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2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite
0 Images2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia.
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Dacarbazine (Standard)
0 ImagesDacarbazine (Standard) is the analytical standard of Dacarbazine. This product is intended for research and analytical applications. Dacarbazine is a nonspecific antineoplastic (antineoplastic) alkylating agent. Dacarbazine inhibits T and B lymphocyte responses with IC50 of 50 and 10 μg/mL, respectively. Dacarbazine can be used in the study of metastatic malignant melanoma.
