Nucleoside Antimetabolite/Analog
Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.
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Nucleoside Antimetabolite/Analog Related Products (2437)
Related Products (2437)
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N1-Propargylpseudouridine
0 ImagesCat. No.: HY-152659CAS No.: 1464021-70-2N1-Propargylpseudouridine (see GL102032) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. N1-Propargylpseudouridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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8-Allylthioadenosine
0 ImagesCat. No.: HY-152542CAS No.: 75059-23-38-Allylthioadenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
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5’-O-DMTr-5-iodo-2’-deoxyuridine
0 ImagesCat. No.: HY-W397503CAS No.: 104375-88-4Synonyms: 2'-Deoxy-5'-O-DMT-5-iodouridine5’-O-DMTr-5-iodo-2’-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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(3Z,6Z)-Nonadienal
0 ImagesCat. No.: HY-W746372CAS No.: 21944-83-2(3Z,6Z)-Nonadienal is a volatile compoound that can be found in the oyster leaf (Mertensia maritima). (3Z,6Z)-Nonadienal shows reminiscent of the oyster-like marine notes.
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Fludarabine phosphate (Standard)
0 ImagesSynonyms: NSC 118218 phosphate (Standard)Fludarabine (phosphate) (Standard) is the analytical standard of Fludarabine (phosphate). This product is intended for research and analytical applications. Fludarabine (phosphate) is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis.
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2,6-Diamino-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine
0 ImagesCat. No.: HY-152773CAS No.: 103884-97-52,6-Diamino-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine is an adenosine analogue. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. The popular products in this series are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
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Methyl 6-amino-9-β-D-ribofuranosyl-9H-purine-2-carboxylate
0 ImagesCat. No.: HY-152372CAS No.: 70255-70-8Methyl 6-amino-9-β-D-ribofuranosyl-9H-purine-2-carboxylate is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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DFP-11207
0 ImagesCat. No.: HY-114249CAS No.: 1296177-16-6DFP-11207 is an orally active fluoropyrimidine cytotoxic agent. DFP-11207 combines a 5-FU (HY-90006) pro-drug with a reversible DPD inhibitor and a potent inhibitor of OPRT, resulting in enhanced pharmacological activity of 5-FU with decreased gastrointestinal and myelosuppressive toxicities. DFP-11207 can be used for the research of cancer .
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2'-Deoxyadenosine-13C10,15N5
0 ImagesCat. No.: HY-W040329SCAS No.: 1987883-24-82'-Deoxyadenosine-13C10,15N5 is 13C and 15N-labeled 2'-Deoxyadenosine (HY-W040329). 2′-Deoxyadenosine is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine inhibits the growth of various cells. 2'-Deoxyadenosine has an anticancer effect on colon cancer.
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N4-Desmethyl wyosine
0 ImagesCat. No.: HY-152795CAS No.: 59327-60-5N4-Desmethyl wyosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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2’,3’-Bis(O-(t-butyldimethylsilyl)-5-methoxyuridine
0 ImagesCat. No.: HY-154418CAS No.: 2305415-94-32’,3’-Bis(O-(t-butyldimethylsilyl)-5-methoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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Vulpecholic acid
0 ImagesCat. No.: HY-180647CAS No.: 107368-95-6Vulpecholic acid is a nucleoside metabolite.
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3'-NH2-GTP tetrasodium
0 ImagesCat. No.: HY-131801A3'-NH2-GTP tetrasodium is a substitute for GTP, produced by inserting an amino acid into the C3 position of GTP.
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2-β-D-Ribofuranosyl-2H-pyrazolo[3,4-d]pyrimidine-4,6-diamine
![2-β-D-Ribofuranosyl-2H-pyrazolo[3,4-d]pyrimidine-4,6-diamine](https://file.medchemexpress.com/product_pic/hy-152408.gif "Click to View 2-β-D-Ribofuranosyl-2H-pyrazolo[3,4-d]pyrimidine-4,6-diamine Product Detail")
0 ImagesCat. No.: HY-152408CAS No.: 124137-35-52-β-D-Ribofuranosyl-2H-pyrazolo[3,4-d]pyrimidine-4,6-diamine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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7-Methylguanosine-13C iodide
0 ImagesCat. No.: HY-122524AS17-Methylguanosine-13C iodide is the 13C-labeled 7-Methylguanosine iodide (HY-122524A). 7-Methylguanosine iodide is an iodide of 7-Methylguanosine (HY-122524). 7-Methylguanosine is a modified nucleoside widely present in various RNAs and a key metabolite of the 5'-cap structure of eukaryotic mRNA. 7-Methylguanosine plays important roles in stabilizing RNA structures, regulating translation, and other aspects.
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(3S,5S)-3,5-Diaminohexanoate
0 ImagesCat. No.: HY-180753CAS No.: 34281-55-5Synonyms: (3S,5S)-DAH(3S,5S)-3,5-Diaminohexanoate ((3S,5S)-DAH) is a nucleoside metabolite.
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2’-Deoxy-2’-fluoro-N3-(n-dodecyl)-beta-D-arabinouridine
0 ImagesCat. No.: HY-152691CAS No.: 2072145-43-6
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4-Chloro-7-(2-deoxy-3,5-bis-O-(p-toluoyl)-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine
![4-Chloro-7-(2-deoxy-3,5-bis-O-(p-toluoyl)-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine](https://file.medchemexpress.com/product_pic/hy-152977.gif "Click to View 4-Chloro-7-(2-deoxy-3,5-bis-O-(p-toluoyl)-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine Product Detail")
0 ImagesCat. No.: HY-152977CAS No.: 91713-43-84-Chloro-7-(2-deoxy-3,5-bis-O-(p-toluoyl)-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine is a pyrimidine nucleoside analog. Pyrimidine nucleoside analogs have a wide range of biochemical and anticancer activities. These include DNA synthesis inhibition, RNA synthesis inhibition, antiviral effects, and immunomodulatory effects.
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Gamma-glutamyl-gamma-aminobutyraldehyde
0 ImagesCat. No.: HY-180716CAS No.: 1135294-88-0Synonyms: γ-Glutamyl-γ-aminobutyraldehydeGamma-glutamyl-gamma-aminobutyraldehyde (γ-Glutamyl-γ-aminobutyraldehyde) is an oxidation product of γ-glutamylputrescine.
