Nucleoside Antimetabolite/Analog
Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.
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Nucleoside Antimetabolite/Analog Related Products (2437)
Related Products (2437)
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2-Chloro-3’-deoxy-3’-fluoroadenosine
0 ImagesCat. No.: HY-152778CAS No.: 122654-30-22-Chloro-3’-deoxy-3’-fluoroadenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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3'-O-(t-Butyldimethylsilyl)-2'-deoxy-2'-fluorouridine
0 ImagesCat. No.: HY-41793CAS No.: 1445379-59-8Synonyms: 2'-Deoxy-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-fluorouridine3'-O-(t-Butyldimethylsilyl)-2'-deoxy-2'-fluorouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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1,2-Di-O-isopropylidene-3-O-methyl-D-ribofuranose
0 ImagesCat. No.: HY-W457757CAS No.: 35506-61-7Synonyms: 1,2-O-Isopropylidene-3-O-Methyl-D-ribofuranose1,2-Di-O-isopropylidene-3-O-methyl-D-ribofuranose is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
0 ImagesCat. No.: HY-180701CAS No.: 95230-80-15-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole is a nucleoside metabolite.
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5’-O-DMTr-N6-ethyl-2’-deoxyadenosine 3’-CED phosphoramidite
0 ImagesCat. No.: HY-1542645’-O-DMTr-N6-ethyl-2’-deoxyadenosine 3’-CED phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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2-Amino-6-chloro-9-(3-deoxy-beta-D-ribofuanosyl)-9H-purine
0 ImagesCat. No.: HY-154477CAS No.: 1055035-48-72-Amino-6-chloro-9-(3-deoxy-beta-D-ribofuanosyl)-9H-purine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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4’-C-Methyl-5-methoxyuridine
0 ImagesCat. No.: HY-152529CAS No.: 2305415-71-6
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7α,25-Dihydroxy-4-cholesten-3-one
0 ImagesCat. No.: HY-180601CAS No.: 98774-41-57α,25-Dihydroxy-4-cholesten-3-one is a sterol metabolite. 25-Hydroxycholesterol is 7α-hydroxylated and further oxidized to 7α,25-Dihydroxy-4-cholesten-3-one.
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5′-Azido-2′,5′-dideoxy-2′-fluorouridine
0 ImagesCat. No.: HY-154305CAS No.: 1012080-88-45′-Azido-2′,5′-dideoxy-2′-fluorouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 5′-Azido-2′,5′-dideoxy-2′-fluorouridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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2-Chloro-6-methoxypurine riboside
0 ImagesCat. No.: HY-W039271CAS No.: 15465-92-6Synonyms: 2-Chloro-6-O-methyl-inosine2-Chloro-6-methoxypurine riboside is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia.
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5'-O-TBDMS-dU
0 ImagesCat. No.: HY-138596CAS No.: 76223-04-65'-O-TBDMS-dU can be used in the synthesis of oligoribonucleotides.
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Demethylphosphinothricin
0 ImagesCat. No.: HY-180686CAS No.: 90183-59-8Synonyms: Deamino-alpha-keto-demethylphosphinothricinDemethylphosphinothricin (Deamino-alpha-keto-demethylphosphinothricin) is a nucleoside metabolite.
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3’-Beta-C-Methyl-N6-(m-trifluoromethylbenzyl)adenosine
0 ImagesCat. No.: HY-1524223’-Beta-C-Methyl-N6-(m-trifluoromethylbenzyl)adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
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2′-β-C-Methyl-2-methoxyadenosine
0 ImagesCat. No.: HY-152816CAS No.: 1829554-43-92′-β-C-Methyl-2-methoxyadenosine is an adenosine analogue. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. The popular products in this series are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
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3’-β-Amino-2’,3’-dideoxy-5’-O-trityl-5-methyl uridine
0 ImagesCat. No.: HY-154439CAS No.: 204688-08-43’-β-Amino-2’,3’-dideoxy-5’-O-trityl-5-methyl uridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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5’-O-DMTr-2’-O-MOE inosine 3’-P-methyl phosphonamidite
0 ImagesCat. No.: HY-1544695’-O-DMTr-2’-O-MOE inosine 3’-P-methyl phosphonamidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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5-(2,3,5-Tri-O-benzyl-beta-D-ribofuranosyl)-3-methyl-2-benzyloxypyridine
0 ImagesCat. No.: HY-154416CAS No.: 1846584-69-75-(2,3,5-Tri-O-benzyl-beta-D-ribofuranosyl)-3-methyl-2-benzyloxypyridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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N6-(4-Methoxybenzyl)adenosine
0 ImagesCat. No.: HY-152303CAS No.: 23666-24-2N6-(4-Methoxybenzyl)adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
