Parasite
Antiparasitics are a class of medications which are indicated for the treatment of parasitic diseases such as nematodes, cestodes, trematodes, and infectious protozoa.
Parasite Isoform Specific Products
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Parasite Related Products (2510)
Related Products (2510)
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Related Compound Screening Libraries (1)
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Parasite Isoform Comparison
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8-Deoxygartanin
0 Images8-Deoxygartanin, a prenylated xanthones from G. mangostana, is a selective inhibitor of butyrylcholinesterase (BChE). 8-Deoxygartanin exhibits antiplasmodial activity with an IC50 of 11.8 μM for the W2 strain of Plasmodium falciparum. 8-Deoxygartanin inhibits NF-κB (p65) activation with an IC50 of 11.3 μM.
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Ferron
0 ImagesSynonyms: 8-Hydroxy-7-iodo-5-quinolinesulfonic acidFerron (8-Hydroxy-7-iodo-5-quinolinesulfonic acid) has antiseptic and antifungal activity. Ferron can prevent skin and mucosa bacterial irritations and inflammations.
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Hydroquinine
0 ImagesHydroquinine (Dihydroquinine) is an anti-bacterial agent that inhibits both Gram-positive and Gram-negative bacteria. Hydroquinine inhibits the growth of multidrug-resistant pseudomonas aeruginosa via the suppression of the arginine deiminase pathway genes. Hydroquinine inhibits Plasmodium falciparum and Plasmodium berghei. Hydroquinine displays anti-malarial and demelanizing activities. Hydroquinine effectively induces specific RND-type efflux pump systems in Pseudomonas aeruginosa, particularly the MexCD-OprJ and MexXY efflux pumps. Hydroquinine inhibits Pseudomonas aeruginosa adhesion and biofilm formation. Hydroquinine serves as a precursor for derivatives such as C9 epihydroquinine, 9-acetoxy-10,11-dihydroquinine, and 10,11-dihydroquinine monohydrochloride.
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3,4-Methylenedioxycinnamic acid
0 Images3,4-Methylenedioxycinnamic acid is an inhibitor of the 4-hydroxycinnamoyl-CoA ligase (4CL) with a Ki of 100 μM. 3,4-Methylenedioxycinnamic acid exhibits the Km value for the substrate ferulic acid of 4CL is 8.4 μM.3,4-Methylenedioxycinnamic acid increases the formation of soluble phenolics in particular of vanillic acid. 3,4-Methylenedioxycinnamic acid demonstrates larvicidal activity.
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Metronidazole-d3
0 ImagesMetronidazole-d3 is deuterium labeled Metronidazole.
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Strictosamide
0 ImagesStrictosamide is a compound that can be isolated from Nauclea officinalis. Strictosamide has various activities such as anti-inflammatory, analgesic, anti-Plasmodium, antifungal, and promoting wound healing.
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Modoflaner
0 ImagesModoflaner is an isophenylamide insecticide. Modoflaner may act through allosteric regulation of gamma-aminobutyric acid-gated chloride channels.
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Diethylcarbamazine citrate
0 ImagesDiethylcarbamazine citrate is an orally active microfilaricidal agent used originally in onchocerciasis and lymphatic filiariasis. Diethylcarbamazine citrate reduces eosinophil trafficking to the lung tissue and exerts anti-allergic effects. Diethylcarbamazine citrate reduces serum levels of leptin, TNF-α, IL-6, MCP-1, glucose, insulin, and triglycerides, and ameliorates insulin resistance without altering body, liver, or adipose tissue weights. Diethylcarbamazine citrate enhances reactive oxygen intermediate expression by polymorphonuclear neutrophils, increases lymphocyte proliferation, and inhibits actinomycetoma lesion development. Diethylcarbamazine citrate can be used for the researches of bronchial asthma, insulin resistance and infection.
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Fosthiazate
0 ImagesFosthiazate is an inhibitor of acetylcholinesterase (Acetylcholinesterase, AChE). Fosthiazate exhibits significant nematicidal activity and systemic insecticidal activity. Fosthiazate is applicable to studies on plant-parasitic nematodes, root-knot diseases, agricultural pests, as well as the ecotoxicology and environmental behavior of organophosphorus compounds.
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LIN28 inhibitor LI71
0 ImagesLIN28 inhibitor LI71 is a LIN28 inhibitor that effectively inhibits LIN28:let-7 binding (IC50: 7 μM). LIN28 inhibitor LI71 can abolish LIN28-mediated oligouridylation of let-7 precursor (IC50: 27 μM). LIN28 inhibitor LI71 has potential application value in LIN28-driven cancer research. LIN28 inhibitor LI71 inhibits the interaction of cold shock protein of Plasmodium falciparum (PfCoSP) with DNA and α/β tubulin and has an inhibitory effect on Plasmodium falciparum.
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Dehydrocorydaline (hydroxyl)
0 ImagesCat. No.: HY-N0674BPurity: 99.52%Synonyms: 13-Methylpalmatine (hydroxyl)Dehydrocorydaline (13-Methylpalmatine) hydroxyl is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP. Dehydrocorydaline hydroxyl elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. Dehydrocorydaline hydroxyl shows strong anti-malarial effects (IC50=38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain.
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Halofuginone lactate
0 ImagesSynonyms: RU-19110 lactateHalofuginone lactate (RU-19110 lactate), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. Halofuginone lactate is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity. Halofuginone lactate is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone lactate has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects.
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Dichlorophen
0 ImagesDichlorophen is a chlorophenol antimicrobial agent that can destroy the integrity of microbial cell membranes and interfere with the activity of metabolic enzymes. Dichlorophen can covalently bind to the thiol groups of microbial proteins and has broad-spectrum antibacterial, antifungal and anthelmintic activity. Dichlorophen can be used as an antimicrobial agent in the study of drug-resistant bacterial infections.
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Naphthoquine phosphate
0 ImagesNaphthoquine phosphate is a potent and orally active antimalarial agent. Naphthoquine phosphate has thorough killing function for various schizonts of plasmodia, including resistance of P. falciparum to Chloroquine.
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Cyantraniliprole
0 ImagesSynonyms: HGW-86Cyantraniliprole (HGW-86) is a potent and selective aniline receptor activator with oral activity. Cyantraniliprole has insecticidal and antioxidant activity.
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Carbosulfan
0 ImagesCarbosulfan is an orally active AChE inhibitor that hydrolyzes to Carbofuran in organisms to exert insecticidal effects. Carbosulfan exhibits broad-spectrum insecticidal activity, and it also induces severe oxidative stress by enhancing lipid peroxidation and impairing the antioxidant defense system. Carbosulfan causes reproductive toxicity in male rats and developmental disorders in their offspring. Carbosulfan shows persistence in paddy field environments and potential hazards to non-target organisms, and it is commonly used in studies related to reproductive toxicity and environmental risk assessment.
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Roridin A
0 ImagesRoridin A acts as an inhibitor of pollen development in Arabidopsis thaliana and nematicide. Roridin A is isolated from the fungus Cylindrocarpon sp. Roridin A delays the flowering time of Arabidopsis thaliana, inhibits pollen development and stem elongation, and blocks plant growth. Roridin A induces larval death of the southern root-knot nematode (Meloidogyne incognita).
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4-Ethylbenzaldehyde
0 Images4-Ethylbenzaldehyde is an aldehyde type organic compound with an almond-like odor. 4-Ethylbenzaldehyde is naturally present in various foods such as grilled meat, black tea, peanuts, etc. 4-Ethylbenzaldehyde has significant effects in controlling plant parasitic nematodes. 4-Ethylbenzaldehyde has genotoxicity and potential for liver damage in zebrafish models.
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Ivermectin B1a
0 ImagesIvermectin B1a, a derivative of Avermectin B1a (HY-15308), is a main component of Ivermectin (HY-15310). Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. Ivermectin is a candidate therapeutic against SARS-CoV-2/COVID-19.
