Prostaglandin Receptor
Prostaglandin receptor, a sub-family of cell surface seven-transmembrane receptors, are the G-protein-coupled receptors. There are currently ten known prostaglandin receptors on various cell types. Prostaglandins bind to a subfamily of cell surface seven-transmembrane receptors, G-protein-coupled receptors. These receptors are named: DP1-2-DP1, DP2 receptors, EP1-4-EP1, EP2, EP3, EP4 receptors, FP-FP, IP1-2-IP1, IP2 receptors, TP-TP receptor. The prostaglandins are a group of hormone-like lipid compounds that are derived enzymatically from fatty acids and have important functions in the animalbody. There are currently ten known prostaglandin receptors on various cell types.
Prostaglandin Receptor Isoform Specific Products
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Prostaglandin Receptor Inhibitors
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Prostaglandin Receptor Agonists
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Prostaglandin Receptor Antagonists
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Prostaglandin Receptor Modulators
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Prostaglandin Receptor Inducers
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Prostaglandin Receptor Degrader
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Prostaglandin Receptor Controls
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Prostaglandin Receptor Ligands
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Prostaglandin Receptor Related Products (767)
Related Products (767)
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Antibodies (2)
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Prostaglandin Receptor Isoform Comparison
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17-Phenyl-18,19,20-trinor-PGD2
0 ImagesCat. No.: HY-137288CAS No.: 85280-91-7Synonyms: 17-Phenyl-PGD217-Phenyl-18,19,20-trinor-PGD2 (17-Phenyl-PGD2) is an analogue of prostaglandin D2 (PGD2; HY-101988). 17-Phenyl-18,19,20-trinor-PGD2 is a potent inhibitor of platelet aggregation caused by aenosine diphosphate (ADP), with the IC50 of 8.4 μM (PGD2 IC50 = 18.6 nM). 17-Phenyl-18,19,20-trinor-PGD2 is a weak agonist of cyclic AMP accumulation.
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Topo I/COX-2-IN-1
0 ImagesCat. No.: HY-150685CAS No.: 3031418-84-2
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Prostaglandin E1 alcohol
0 ImagesCat. No.: HY-137133CAS No.: 21562-57-2Prostaglandin E1 alcohol (compound 89) is a prostaglandin analog.
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ACT-774312
0 ImagesCat. No.: HY-182637CAS No.: 1809863-68-0ACT-774312 is a potent and selective CRTH2 antagonist with an IC50 of 4 nM. ACT-774312 blocks the activity and internalization of the CRTH2 receptor, and inhibits PGD2-induced morphological changes in eosinophils. ACT-774312 can be used in the research of nasal polyps and type 2 inflammatory diseases.
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GSK345931A
0 ImagesCat. No.: HY-111258CAS No.: 869499-38-7GSK345931A is an EP1 receptor antagonist. GSK345931A shows measurable CNS penetration in the mouse and rat and potent analgesic efficacy in acute and sub-chronic models of inflammatory pain.
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MK-1029
0 ImagesCat. No.: HY-123787CAS No.: 1242273-04-6MK-1029 is a DP2 antagonist. MK-1029 can be used in research on respiratory diseases such as asthma.
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L-10503
0 ImagesCat. No.: HY-129638CAS No.: 55308-37-7L-10503 is a non-hormonal non-prostaglandin antifertility compound.
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(R)-L 888607
0 Images(R)-L 888607 is the isomer of L 888607 (HY-111271), and can be used as an experimental control. L 888607 is a potent, selective, stable and orally active CRTH2 agonist. L 888607 has high affinity for the human CRTH2 receptor with a Ki value of 4 nM. L 888607 can be used for the research of several physiological events and metabolite.
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AD 4743
0 ImagesCat. No.: HY-121058CAS No.: 87858-57-9Synonyms: ADD 4743AD 4743 (ADD 4743) is a metabolite of Ciglitazone (HY-W011220). AD 4743 is an adipogenic agent. AD 4743 induces FPRP accumulation and accumulation of lipid droplets. AD 4743 inhibits cell proliferation of preadipose cells.
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Irodanoprost
0 ImagesCat. No.: HY-168978CAS No.: 2055490-48-5Irodanoprost is the agonist for prostaglandin receptor that can be used for research of osteogenesis-related diseases.
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Prostaglandin D2 methyl ester
0 ImagesCat. No.: HY-114623CAS No.: 49852-81-5Prostaglandin D2 methyl ester is a prodrug form of Prostaglandin D2 (HY-101988) that acts as a DP receptor inhibitor. can be used for research on allergic inflammations.
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16(R)-Iloprost
0 ImagesCat. No.: HY-118670ACAS No.: 74843-13-316(R)-Iloprost is a stereoisomer of Iloprost. 16(R)-Iloprost inhibited platelet aggregation with IC50 value of 65 nM.
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Treprostinil-d7
0 ImagesCat. No.: HY-100441S3Synonyms: UT-15-d7Treprostinil-d7 (UT-15-d7) is a deuterated version of Treprostinil (HY-100441). Treprostinil is a highly potent DP1 and EP2 agonist with EC50s of 0.6 nM and 6.2 nM, respectively.
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Prostaglandin E1-d9
0 ImagesCat. No.: HY-B0131S2CAS No.: 2342573-59-3Synonyms: Alprostadil-d9; PGE1-d9Prostaglandin E1-d9 is deuterium labeled Prostaglandin E1.Prostaglandin E1 is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inh
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ZPL-5212372
0 ImagesCat. No.: HY-124852CAS No.: 916136-25-9Synonyms: PF 5212372ZPL-5212372 (PF 5212372) is a cPLA2α inhibitor (IC50 = 7 nM). ZPL-5212372 inhibits the release of prostaglandin D2 (PGD2), cysteyl leukotrienes, leukotriene B4, thromboxane A2, and PGD2 from human lung cells. ZPL-5212372 inhibits delayed bronchoconstriction and airway hyperresponsiveness in a sheep allergic inflammation model. ZPL-5212372 may be used in asthma research.
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(Rac)-Beraprost
0 ImagesCat. No.: HY-167091CAS No.: 88430-50-6Synonyms: (Rac)-TRK-100 free acid; (Rac)-ML 1229(Rac)-Beraprost ((Rac)-ML 1229) is an orally active prostacyclin analog that inhibits the release of Ca2+ from intracellular storage sites by binding to prostacyclin membrane receptors (Prostaglandin Receptor), leading to relaxation of smooth muscle cells and vasodilation. Beraprost has vasodilatory, antiplatelet, and cytoprotective effects, making it promising for research in the field of cardiovascular diseases, such as thromboangiitis obliterans and atherosclerosis.
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11-Dehydro-thromboxane B2-13C5
0 ImagesCat. No.: HY-113420S211-Dehydro-thromboxane B2-13C5 is the 13C-labeled 11-Dehydro-thromboxane B2 (HY-113420). 11-Dehydro-thromboxane B2 is a stable terminal metabolite of thromboxane A2 and an agonist of the CRTH2 receptor. 11-Dehydro-TXB2 activates human eosinophils, basophils, and CRTH2-transfected BaF/3 cells through a pertussis toxin-insensitive G protein-PLC pathway, inducing intracellular calcium mobilization, morphological changes, and chemotaxis, but does not affect platelet aggregation. 11-Dehydro-thromboxane B2 is involved in thrombosis and promotes eosinophil recruitment to the lungs in allergic inflammation, and its urinary levels are used to assess the inhibitory effect of Aspirin (HY-14654) on thromboxane production. 11-Dehydro-TXB2 serves as a biomarker for research related to asthma, atopic rhinitis, nephropathy, and coronary artery disease.
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11-Deoxy prostaglandin E1
0 ImagesCat. No.: HY-128043CAS No.: 37786-00-8Synonyms: AY-23578; Doproston B; 11-Deoxy-PGE111-Deoxy prostaglandin E1 (AY-23578; Doproston B) is an analog of prostaglandin E1 (PGE1) with bronchodilator activity. 11-Deoxy prostaglandin E1 inhibits histamine-induced bronchoconstriction and causes relaxation of tracheal strips in isolated guinea pigs.
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8-(6,7-Dihydroxy-3,7-dimethyl-2E-octenyloxy)psoralen
0 ImagesCat. No.: HY-N15589CAS No.: 889112-17-88-(6,7-Dihydroxy-3,7-dimethyl-2E-octenyloxy)psoralen is a compound found in Citrus grandis. 8-(6,7-Dihydroxy-3,7-dimethyl-2E-octenyloxy)psoralen has significant anti-inflammatory activity, which mainly works by inhibiting the secretion of inflammatory factors IL-1β, PGE2 and TNF-α. 8-(6,7-Dihydroxy-3,7-dimethyl-2E-octenyloxy)psoralen can be used in the study of inflammation.
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NVP-QAV680
0 ImagesCat. No.: HY-12284CAS No.: 872365-16-7NVP-QAV680 is a potent and selective CRTh2 receptor antagonist with low nanomolar (nM) functional potency to inhibit CRTh2-driven activation of human eosinophils and Th2 lymphocytes. NVP-QAV680 exhibits good oral bioavailability and demonstrates efficacy in CRTh2-dependent mechanisms and allergic disease models in rats.
