Prostaglandin Receptor
Prostaglandin receptor, a sub-family of cell surface seven-transmembrane receptors, are the G-protein-coupled receptors. There are currently ten known prostaglandin receptors on various cell types. Prostaglandins bind to a subfamily of cell surface seven-transmembrane receptors, G-protein-coupled receptors. These receptors are named: DP1-2-DP1, DP2 receptors, EP1-4-EP1, EP2, EP3, EP4 receptors, FP-FP, IP1-2-IP1, IP2 receptors, TP-TP receptor. The prostaglandins are a group of hormone-like lipid compounds that are derived enzymatically from fatty acids and have important functions in the animalbody. There are currently ten known prostaglandin receptors on various cell types.
Prostaglandin Receptor Isoform Specific Products
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Prostaglandin Receptor Inhibitors
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Prostaglandin Receptor Agonists
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Prostaglandin Receptor Antagonists
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Prostaglandin Receptor Activators
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Prostaglandin Receptor Modulators
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Prostaglandin Receptor Inducers
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Prostaglandin Receptor Degrader
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Prostaglandin Receptor Controls
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Prostaglandin Receptor Ligands
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Prostaglandin Receptor Related Products (763)
Related Products (763)
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Antibodies (2)
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Prostaglandin Receptor Isoform Comparison
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5-trans-PGE2
0 ImagesCat. No.: HY-135023CAS No.: 36150-00-2Synonyms: 5-trans Prostaglandin E25-trans-PGE2 (5-trans Prostaglandin E2) is the active isomer of PGE2 and a potent activator of aromatase. Supplements the process of paracrine signaling between epithelial cells (expressing high levels of PGE2) and surrounding stromal cells (expressing high levels of aromatase). This process is involved in the growth and development of breast cancer.
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AL-6556
0 ImagesCat. No.: HY-182473CAS No.: 170552-18-8AL-6556 is a full agonist of the DP receptor and a partial agonist of the EP2 receptor. AL-6556 has an EC50 of 799 nM for bovine DP, a Ki of 3200 nM for human DP, and an EC50 of 1180 nM for human EP2, with selectivity over EP3, FP, IP, TP and 19 non-prostaglandin receptors. AL-6556 stimulates cAMP production via receptor activation and reduces intraocular pressure through aqueous humor inflow and outflow mechanisms. AL-6556 can be used in research related to ocular hypertension and glaucoma.
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8-Iso prostaglandin E2 isopropyl ester
0 ImagesCat. No.: HY-169028CAS No.: 330589-21-48-Iso prostaglandin E2 isopropyl ester is a more lipophilic form of the free acid, 8-iso Prostaglandin E2.
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(R)-Vorbipiprant
0 ImagesCat. No.: HY-163651CAS No.: 2502965-92-4Synonyms: (R)-CR6086(R)-Vorbipiprant ((R)-CR6086) is an orally active antagonist for prostaglandin E2 receptor 4 (EP4) with Ki of 16.6 nM for human EP4. (R)-Vorbipiprant inhibits PGE2 (HY-101952)-induced cAMP production with an IC50 of 22 nM. (R)-Vorbipiprant exhibits immunomodulatory and anti-angiogenic activities, and ameliorates the collagen-induced arthritis in mice.
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Dinoprost-d9
0 ImagesCat. No.: HY-12956S1Synonyms: Prostaglandin F2a-d9; PGF2α-d9Dinoprost-d9 is the deuterium labeled Dinoprost. Dinoprost (Prostaglandin F2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour.
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Furegrelate
0 ImagesCat. No.: HY-106080CAS No.: 85666-24-6Synonyms: U-63557A free acidFuregrelate (U-63557A free acid) is a potent, orally available, and selective thromboxane synthase inhibitor. Furegrelate inhibits human platelet microsomal thromboxane A2 (TxA2) synthase with an IC50 of 15 nM. Furegrelate is being developed as an antiplatelet agent.
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5-cis Carbaprostacyclin
0 ImagesCat. No.: HY-124363CAS No.: 69609-77-45-cis Carbaprostacyclin is a stable analog of PGI2 based on Carbaprostacyclin (HY-112322). Carbacyclin is a PGI2 receptor agonist and vasodilator that activates PPARδ. 5-cis Carbaprostacyclin induces relaxation of pulmonary vascular tone.
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TGI-15
0 ImagesCat. No.: HY-178792CAS No.: 3073601-32-5TGI-15 is a highly selective prostaglandin F receptor antagonist. TGI-15 inhibits downstream signaling pathways by blocking the binding of PGF2 α to FP receptors. TGI-15 can be used for research on fibrotic and inflammatory conditions.
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15(S)-15-Methyl Prostaglandin F2α ethyl amide
0 ImagesCat. No.: HY-18144315(S)-15-Methyl Prostaglandin F2α ethyl amide (15-Methyl Prostaglandin F2α ethyl amide) is a synthetic Prostaglandin F2α (HY-12956) analogue that stimulates uterine contractions. 15(S)-15-Methyl Prostaglandin F2α ethyl amide can be used for the research of second-trimester pregnancy loss.
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15-deoxy-Δ12,14-Prostaglandin D2-d4
0 ImagesCat. No.: HY-116028S1CAS No.: 2750534-91-7Synonyms: 15-Deoxy-Δ12,14-PGD2-d415-Deoxy-Δ12,14-Prostaglandin D2-d4 (15-Deoxy-Δ12,14-PGD2-d4) is the deuterium labeled 15-deoxy-Δ12,14-Prostaglandin D2. 15-deoxy-Δ12,14-Prostaglandin D2 (15-Deoxy-Δ12,14-PGD2) is a metabolite of prostaglandin D₂ (PGD₂) (HY-101988), which can undergo further dehydration metabolism to 15-deoxy-Δ12,14-PGJ₂. 15-deoxy-Δ12,14-Prostaglandin D2 is a highly selective agonist for DP2 receptor and PPARγ. 15-deoxy-Δ12,14-Prostaglandin D2 causes morphological changes in eosinophils and migration of type II innate lymphoid cells (ILC2). 15-deoxy-Δ12,14-Prostaglandin D2 has a growth inhibitory effect on prostate cancer cells expressing PPARγ, induces cell cycle arrest and promotes apoptosis. 15-deoxy-Δ12,14-Prostaglandin D2 can be used in related research on asthma and prostate cancer.
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16,16-Dimethylprostaglandin F2β
0 ImagesCat. No.: HY-116051ACAS No.: 59769-89-0Synonyms: 16,16-Dimethyl-PGF2β16,16-Dimethylprostaglandin F2β (16,16-Dimethyl-PGF2β) is an analog of PGF2β (HY-12956B), which is an irratant, but prevents the aspecifically induced bronchospasm.
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EP1 receptor antagonist-1
0 ImagesCat. No.: HY-177544CAS No.: 330795-70-5EP1 receptor antagonist-1 (Compound Example 5a freebase) is an EP1 prostaglandin receptor antagonist. EP1 receptor antagonist-1 is promising for research of urinary system-related diseases.
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(+)-Cloprostenol sodium
0 ImagesCat. No.: HY-107381ACAS No.: 62561-03-9Synonyms: D-Cloprostenol sodium(+)-Cloprostenol sodium is a prostaglandin F2α (PGF2α) analogue, and shows selective agonistic activity at the prostaglandin receptor.
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Selexipag-d6
0 ImagesCat. No.: HY-14870S3CAS No.: 1265295-92-8Synonyms: NS-304-d6; ACT-293987-d6Selexipag-d6 is deuterium labeled Selexipag. Selexipag (NS-304) is an orally available and potent agonist for the Prostacyclin (PGI2) receptor (IP receptor).
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15-Keto Bimatoprost
0 ImagesCat. No.: HY-132277CAS No.: 1163135-96-315-Keto Bimatoprost is a prostaglandin F2α (PGF2α) analog that can be used for the research of ocular hypotensive.
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Alclofenac (lysinate)
0 ImagesCat. No.: HY-W009706BCAS No.: 59960-34-8Synonyms: Allopydin (lysinate); W-7320 (lysinate)Alclofenac (Allopydin) lysinate is an orally active prostaglandin synthase inhibitor with anti-inflammatory, analgesic and antipyretic activities. Alclofenac lysinate irreversibly inhibits platelet aggregation. Alclofenac lysinate can be used in research related to rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, low back pain and sciatica.
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L-644698
0 ImagesCat. No.: HY-122147CAS No.: 72313-41-8L-644698 is a potent and selective human recombinant prostaglandin D2 (PGD2) receptor (hDP) agonist with Ki values of 0.9, 267, 3730, 9280 nM for hDP, hEP2, hEP3, hEP4, respectively. L-644698 induces cyclic AMP production with an EC50 value of 0.5 nM.
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MK-447
0 ImagesCat. No.: HY-100297CAS No.: 58456-91-0MK-447 is a free radical scavenger, also a nonsteroidal antiinflammatory agent, and enhances the formation of the endoperoxide, PGH2, and other prostaglandins.
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15-keto-17-phenyl trinor Prostaglandin F2α
0 ImagesCat. No.: HY-113778CAS No.: 949564-89-0Synonyms: 15-keto-17-phenyl trinor PGF2α15-keto-17-phenyl trinor Prostaglandin F2α (15-keto-17-phenyl trinor PGF2α) is an F-series prostaglandin (PG) analog. The potential metabolite of 15-keto-17-phenyl trinor Prostaglandin F2α in animals is 15-keto PG. 15-keto PG can slightly reduce the intraocular pressure (1 mm Hg) in normal cynomolgus monkeys when administered at a dose of 1 μg/eye. 15-keto-17-phenyl trinor Prostaglandin F2α is a miotic agent in cats, reducing the pupil diameter by 8 mm at a dose of 5 μg/eye.
