Prostaglandin Receptor
Prostaglandin receptor, a sub-family of cell surface seven-transmembrane receptors, are the G-protein-coupled receptors. There are currently ten known prostaglandin receptors on various cell types. Prostaglandins bind to a subfamily of cell surface seven-transmembrane receptors, G-protein-coupled receptors. These receptors are named: DP1-2-DP1, DP2 receptors, EP1-4-EP1, EP2, EP3, EP4 receptors, FP-FP, IP1-2-IP1, IP2 receptors, TP-TP receptor. The prostaglandins are a group of hormone-like lipid compounds that are derived enzymatically from fatty acids and have important functions in the animalbody. There are currently ten known prostaglandin receptors on various cell types.
Prostaglandin Receptor Isoform Specific Products
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Prostaglandin Receptor Inhibitors
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Prostaglandin Receptor Agonists
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Prostaglandin Receptor Antagonists
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Prostaglandin Receptor Activators
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Prostaglandin Receptor Modulators
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Prostaglandin Receptor Inducers
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Prostaglandin Receptor Degrader
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Prostaglandin Receptor Controls
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Prostaglandin Receptor Ligands
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Prostaglandin Receptor Related Products (766)
Related Products (766)
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Antibodies (2)
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Prostaglandin Receptor Isoform Comparison
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ONO 3708
0 ImagesCat. No.: HY-106105CAS No.: 102191-05-9ONO 3708 is a TXA2/PGH2 receptor antagonist that can inhibit the binding properties of U46619 in unactivated intact human platelets, with an IC50 value of 38 nM.
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Misoprostol acid-d5
0 ImagesCat. No.: HY-118189SCAS No.: 1337917-44-8Misoprostol acid-d5 is deuterium labeled Misoprostol acid. Misoprostol acid is an active metabolite of Misoprostol. Misoprostol is a synthetic analogue of prostaglandin E1 (PGE1), extensively absorbed, and undergoes rapid de-esterification to Misoprostol acid in the gastrointestinal tract after oral administration. Misoprostol can be used for non-steroidal anti-inflammatory drug-induced (NSAID) gastric ulcers. Misoprostol is an oral agent used to induce labor.
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2,3-Dinor thromboxane b1
0 ImagesCat. No.: HY-120975CAS No.: 196493-76-22,3-Dinor thromboxane b1 is an urinary metabolite of Thromboxane B2 (HY-113331).
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15(R)-Prostaglandin E2
0 ImagesCat. No.: HY-130694CAS No.: 38873-82-4Synonyms: 15-epi-Prostaglandin E215(R)-Prostaglandin E2 is a prostaglandin derivative that can be isolated from the Plexaura homomalla .
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PROTAC(H-PGDS)-8
0 ImagesCat. No.: HY-157577CAS No.: 2761281-51-8
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BM-531
0 ImagesCat. No.: HY-135447CAS No.: 284464-46-6BM-531 is a dual-acting agent for thromboxane receptor (TXA2) antagonism and thromboxane synthase inhibition. BM-531 exerts anti-aggregatory effects on human citrated platelet-rich plasma (PRP), inhibiting Arachidonic acid (HY-109590A)-induced aggregation with an ED100 of 0.125 μM and U-46619 (HY-108566)-induced aggregation with an ED50 of 0.482 μM. BM-531 inhibits high-K+-induced contraction of porcine uterine smooth muscle.
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Latanoprost ethyl amide-d4
0 ImagesCat. No.: HY-129934SSynonyms: Lat-NEt-d4Latanoprost ethyl amide-d4 (Lat-NEt-d4) is deuterium labeled Latanoprost ethyl amide. Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters have been shown to have ocular hypotensive activity.1 Prostaglandin N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs. Although it has been claimed that prostaglandin ethyl amides are not converted to the free acids in vivo, studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 μg/g corneal tissue/hr. Lat-NEt would be expected to show the typical intraocular effects of Latanoprost free acid, but with the much slower hydrolysis pharmacokinetics of the prostaglandin N-amides.
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E-6700
0 ImagesCat. No.: HY-19166CAS No.: 144562-61-8E-6700 is an inhibitor of 5-LO and TXA2 synthetase, with IC50s of 16.3 μM and 0.026 μM respectively. E-6700 inhibits LTB4 and TXB2 production. E-6700 can be used for antiinflammatory research.
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TP-16
0 ImagesCat. No.: HY-143518CAS No.: 2332972-26-4TP-16 is a novel and selective EP4 antagonist with an IC50 of 2.1 nM.
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EP4 receptor agonist-4
0 ImagesCat. No.: HY-182969EP4 receptor agonist-4 is an orally active, selective EP4 receptor agonist, with a binding IC50 of 18 nM against human receptors, and agonistic EC50 values of 2.1 nM and 0.11 μM against human and murine receptors, respectively. EP4 receptor agonist-4 inhibits hERG channel activity with an IC50 of 10.2 μM. It can be used in the research of inflammatory bowel disease (colitis).
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CRTh2 antagonist 1
0 ImagesCat. No.: HY-112265CAS No.: 1379445-54-1CRTh2 antagonist 1 is a CRTh2 antagonist with an IC50 of 89 nM.
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SC-42867
0 ImagesCat. No.: HY-105894CAS No.: 102251-91-2SC-42867 is a PGE2 antagonist. SC-42867 can be metabolized in the liver through oxidative N-dealkylation, aromatic hydroxylation, and binding reactions. SC-42867 can be used for research on metabolic conditions.
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AGN 210676
0 ImagesCat. No.: HY-14898CAS No.: 910562-15-1Synonyms: SimenepagAGN 210676 is a selective prostaglandin EP2 agonist extracted from patent US20070203222A1, Compound example 23, has an EC50 of 5 nM.
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OP-2507
0 ImagesCat. No.: HY-106110CAS No.: 101758-79-6OP-2507 is a prostacyclin analog. OP-2507 can increase brain glucose levels in mice, suppress the breakdown of energy metabolism under hypoxic conditions, and has a protective effect against changes in cyclic nucleotides in hypoxic brain tissue (specifically, an increase in cyclic AMP and a decrease in cyclic GMP). OP-2507 provides protective effects against brain hypoxia and edema.
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KC-764
0 ImagesCat. No.: HY-100484CAS No.: 94457-09-7KC-764 is an orally active, reversible cyclooxygenase inhibitor with relative selectivity for platelet cyclooxygenase. KC-764 inhibits platelet thromboxane A2 (TXA2) production and platelet aggregation, with IC50s of 0.23 μM and 26 nM, respectively. KC-764 can be used for the research on antiplatelet and recurrence prevention in ischemic stroke.
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(E/Z)-Ozagrel sodium
0 ImagesCat. No.: HY-B0428DCAS No.: 130952-46-4Synonyms: (E/Z)-OKY-046 sodium(E/Z)-Ozagrel sodium [(E/Z)-OKY-046 sodium] is an EZ configuration mixture of Ozagrel sodium (HY-B0428A). Ozagrel sodium (OKY-046 sodium) is a high selective and orally active thromboxane A2 (TXA2) synthase inhibitor with an IC50 of 11 nM. Ozagrel sodium exerts anti-platelet aggregation, vasodilation and anti-inflammatory effects by inhibiting the production of TXA2 and increasing the production of prostacyclin (PGI2). Ozagrel sodium can be used for the study of ischemic stroke, asthma and thromboembolic diseases.
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CAY10535
0 ImagesCat. No.: HY-118014CAS No.: 945716-28-9CAY10535 is a FP and TP receptor inhibitor and can be used for research of cardiovascular diseases.
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Carbaprostacyclin methyl ester
0 ImagesCat. No.: HY-126084CAS No.: 69552-55-2Carbaprostacyclin methyl ester is a methylated derivative of Carbacyclin (HY-112322).
