Prostaglandin Receptor
Prostaglandin receptor, a sub-family of cell surface seven-transmembrane receptors, are the G-protein-coupled receptors. There are currently ten known prostaglandin receptors on various cell types. Prostaglandins bind to a subfamily of cell surface seven-transmembrane receptors, G-protein-coupled receptors. These receptors are named: DP1-2-DP1, DP2 receptors, EP1-4-EP1, EP2, EP3, EP4 receptors, FP-FP, IP1-2-IP1, IP2 receptors, TP-TP receptor. The prostaglandins are a group of hormone-like lipid compounds that are derived enzymatically from fatty acids and have important functions in the animalbody. There are currently ten known prostaglandin receptors on various cell types.
Prostaglandin Receptor Isoform Specific Products
All Product Categories
-
Prostaglandin Receptor Inhibitors
(171)
View all products
-
Prostaglandin Receptor Agonists
(193)
View all products
-
Prostaglandin Receptor Antagonists
(178)
View all products
-
Prostaglandin Receptor Activators
(25)
View all products
-
Prostaglandin Receptor Modulators
(4)
View all products
-
Prostaglandin Receptor Inducers
(2)
View all products
-
Prostaglandin Receptor Degrader
(1)
View all products
-
Prostaglandin Receptor Controls
(49)
View all products
-
Prostaglandin Receptor Ligands
(3)
View all products
-
Prostaglandin Receptor Related Products (767)
Related Products (767)
-
Antibodies (2)
-
Prostaglandin Receptor Isoform Comparison
-
EP3 antagonist 4
0 ImagesCat. No.: HY-153256CAS No.: 2408297-80-1EP3 antagonist 4 (Compound 28) is an EP3 antagonist, with a Ki value of 2 nM for hEP. EP3 antagonist 4 shows low in vivo clearance, high oral AUC, and good bioavailability in the rat full PK studies. EP3 antagonist 4 can be used for research of beta cell dysfunction in diabetes.
-
Prostaglandin F2α alcohol methyl ether
0 ImagesCat. No.: HY-117061CAS No.: 143656-18-2Prostaglandin F2α alcohol methyl ether is an alcohol methyl ether G protein-coupled receptor. Prostaglandin F2α is also a luteinizing hormone in sheep and may be a nociceptive mediator in the spinal cord.
-
trans-Isoferulic acid-d3
0 ImagesCat. No.: HY-N0761ASCAS No.: 1028203-97-5trans-Isoferulic acid-d3 is the deuterium labeled trans-Isoferulic acid. trans-Isoferulic acid (trans-3-Hydroxy-4-methoxycinnamic acid) is an aromatic acid isolated from the roots of Clematis florida var. plena. trans-Isoferulic acid exhibits anti-inflammatory activity.trans-isoferulic acid suppresses NO and PGE2 production through the induction of Nrf2-dependent heme oxygenase-1 (HO-1).
-
Trapidil (Standard)
0 ImagesCat. No.: HY-B1016RCAS No.: 15421-84-8Synonyms: AR-12008 (Standard)Trapidil (Standard) (AR-12008 (Standard)) is the analytical standard of Trapidil (HY-B1016R). This product is intended for research and analytical applications. Trapidil (AR-12008) is an orally active vasodilator and antiplatelet agent. Trapidil antagonizes platelet-derived growth factor (PDGF), inhibits phosphodiesterase, thromboxane A2 synthesis and pro-inflammatory cytokine production. Trapidil promotes prostacyclin biosynthesis, reduces lipid peroxidation, regulates nitric oxide metabolism, and inhibits cell proliferation and migration. Trapidil exerts tissue-protective effects, regulates bone turnover, and inhibits pyroptosis via the GPX3/Nrf2 pathway. Trapidil is applicable to research related to renal ischemia-reperfusion injury, chronic stable angina, restenosis, meningioma, diabetic cardiomyopathy and peripheral nerve crush injury.
-
15-Deoxy-16-hydroxy-16-vinyl-PGE2 Me ester
0 ImagesCat. No.: HY-105135CAS No.: 73621-92-815-Deoxy-16-hydroxy-16-vinyl-PGE2 Me ester is the (R,R,R)-isomer of Viprostol (HY-105135A) and a PGE2 analogue with antihypertensive property. 15-Deoxy-16-hydroxy-16-vinyl-PGE2 Me ester can be utilized in cardiovascular disease research.
-
15-OH Tafluprost
0 ImagesCat. No.: HY-118294CAS No.: 130209-78-8Synonyms: 16-Phenoxy tetranor prostaglandin F2α isopropyl ester; 16-Phenoxy tetranor PGF2α isopropyl ester15-OH Tafluprost, a prostaglandin F2a (PGF2a) analog, relieves endothelin-1 (ET-1)-induced optic nerve head (ONH) blood flow impairment and ET-1-induced contraction of isolated ciliary artery segments.
-
Prostaglandin E1 (Standard)
0 ImagesProstaglandin E1 (Standard) is the analytical standard of Prostaglandin E1. This product is intended for research and analytical applications. Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases.
-
CRTh2 antagonist 4
0 ImagesCat. No.: HY-116890CAS No.: 916046-55-4CRTh2 antagonist 4 (compound 58) is an inhibitor (IC50: 212 nM) of TH2 lymphocyte (CRTH2 or DP2) receptor with high binding affinity (Ki= 37 nM). CRTh2 antagonist 4 can be used in the study of severe allergic diseases.
-
Prostaglandin F1β
0 ImagesCat. No.: HY-113887CAS No.: 10164-73-5Synonyms: PGF1βProstaglandin F1β (PGF1β) is the C-9 epimer of 1α. Prostaglandin F1β increased the respiratory rate of rabbits.
-
BPN-37440
0 ImagesCat. No.: HY-183149CAS No.: 3120759-70-5BPN-37440 is a blood-brain barrier-permeable, selective, and orally active EP2 receptor inhibitor with an IC50 of 53-60 nM. BPN-37440 inhibits the expression of inflammatory mediators IL-1β and COX-2, with an IC50 of 21 nM for IL-1β and 42 nM for COX-2. BPN-37440 reduces microgliosis in key brain regions of mice with pilocarpine (HY-B0726A)-induced status epilepticus and reverses their working memory and recognition memory deficits. BPN-37440 can be used for research on status epilepticus.
-
Thromboxane B2-d9
0 ImagesCat. No.: HY-113331S1Thromboxane B2-d9 is deuterium labeled Thromboxane B2. Thromboxane B2 is a prostaglandin derivative that is released during anaphylaxis. Thromboxane B2 induces arterial contraction and platelet aggregation.
-
Grapiprant-d4
0 ImagesCat. No.: HY-16781SSynonyms: CJ-023423-d4; RQ-00000007-d4; AAT-007-d4Grapiprant-d4 (CJ-023423-d4) is the deuterium labeled Grapiprant (HY-16781). Grapiprant (CJ-023423) is a selective EP4 receptor antagonist whose physiological ligand is prostaglandin E2 (PGE2). Grapiprant displaces [3H]-PGE2 (1 nM) binding to dog recombinant EP4 receptor with IC50 value of 35 nM and Ki value of 24 nM. Grapiprant has the potential for osteoarthritic pain and inflammation treatment[3] .
-
12(S)-HPEPE
0 ImagesCat. No.: HY-113913CAS No.: 103239-14-112(S)-HPEPE is a lipoxygenase product and an intermediate metabolite that leads to downregulation of PGHS-2 and has potential anti-inflammatory activity. 12(S)-HPEPE reduces interleukin 1h (IL-1h)-induced PGHS-2 expression in human lung microvascular endothelial cells.
-
Δ17-6-keto Prostaglandin F1α
0 ImagesCat. No.: HY-118652CAS No.: 68324-95-8Synonyms: ω-3 6-keto PGF2αΔ17-6-keto Prostaglandin F1α (Δ17-6-keto PGF1α) is a cyclooxygenase (COX) product of eicosapentaenoic acid (EPA) in various tissues such as seminal vesicles, lung, Polymorphonuclear leukocytes, and ocular tissues. Δ17-6-keto PGF1α and other 3-series COX products from EPA, such as PGF3α, PGE3, and thromboxane B3, may be involved in the reduced incidence of glaucoma in patients on a marine-rich (EPA-rich) diet.
-
EP4 receptor agonist 1
0 ImagesCat. No.: HY-150068CAS No.: 691869-12-2EP4 receptor agonist 1 (compound 11) is an EP4 receptor agonist with the human pEC50 value of 6.3.
-
Imitrodast sodium
0 ImagesCat. No.: HY-105114ACAS No.: 113817-57-5Synonyms: CS-518Imitrodast sodium is an inhibitor of thromboxane synthase. Imitrodast sodium can be used in the research of bronchoconstriction.
-
Besvoprost
0 ImagesCat. No.: HY-187890CAS No.: 215863-14-2Besvoprost is a prostaglandin receptor activator with antiglaucoma activity. Besvoprost can be used for the research of glaucoma.
-
Nocistatin(human)
0 ImagesCat. No.: HY-P1020CAS No.: 212609-11-5Nocistatin (human) blocks nociceptin-induced allodynia and hyperalgesia, and attenuates pain evoked by prostaglandin E2.
-
Amtolmetin guacil
0 ImagesAmtolmetin guacil is an effective nonsteroidal anti-Inflammatory agent with pain-relieving effects. Amtolmetin guacil inhibits prostaglandin synthesis and cyclooxygenase (COX). Amtolmetin guacil can stimulate capsaicin receptors present on the gastrointestinal wall and also releases gastroprotective nitric oxide (NO). Amtolmetin guacil can be used to research knee osteoarthritis.
-
ent-8-iso Prostaglandin F2α
0 ImagesCat. No.: HY-114593CAS No.: 159812-83-6Synonyms: ent-15-F2t-IsoPent-8-iso Prostaglandin F2α (ent-15-F2t-IsoP) is a potent vasoconstrictor of porcine retina and cerebral microvessels with EC50 values of 30.6 and 53.5 nM, respectively.
