2. Signaling Pathways
  3. MAPK/ERK Pathway
  4. Raf
  5. B-Raf Isoform
  6. B-Raf Modulator

B-Raf Modulator

B-Raf Modulator (1):

Cat. No. Product Name Effect Purity
  • HY-179012
    CDC20/HSP90-IN-1
    		Modulator
    CDC20/HSP90-IN-1 (Compound 2b) is a Cdc20/Hsp90 inhibitor with a Kd of 16.2 μM for Cdc20 and a Kd of 0.241 μM for Hsp90α. CDC20/HSP90-IN-1 exerts potent antitumor activity through reducing p53-mediated Cdc20, upregulating Bim, downregulating Cyclin B1 expression, and disturbing B-Raf and AKT pathways via destroying Hsp90 chaperone function. CDC20/HSP90-IN-1 overcomes Vemurafenib (HY-12057)-induced resistant melanoma.