K-Ras Ligand

Thalidomide 5-fluoride is a thalidomide-based Cereblon ligand used to recruit Cereblon protein. Thalidomide 5-fluoride can be linked to target protein ligands (e.g. IRAK4) through a linker to form PROTAC molecules (e.g. PROTAC IRAK4 degrader-1). PROTAC IRAK4 degrader-1 caused <20%, >20-50%, and >50% IRAK4 protein degradation in OCI-LY-10 cells at concentrations of 0.01, 0.1, and 1 μM, respectively.

KRAS ligand 1 is a KRAS^G12C ligand and can be used for the synthesis of PROTACs, such as PROTAC KRAS G12C degrader-1 (HY-139186).

KRAS ligand 6 (Compound 37) is a KRAS ligand. KRAS ligand 6 can be used as a Ligand for Target Protein for PROTAC to synthesize KRAS PROTAC degraders, such as RP04340 (HY-189222). KRAS ligand 6 can be used for research on KRAS-driven cancers, including pancreatic ductal adenocarcinoma, colorectal cancer, and lung adenocarcinoma.

KRASG12C ligand-2 is a KRas ligand used for PROTAC synthesis. KRASG12C ligand-2 serves as the target protein ligand of PROTAC KRAS G12C degrader-2 (HY-153821).

KRAS ligand-7 is a ligand for KRAS and can be used in research related to PROTAC synthesis. KRAS ligand-7 can serve as the target protein ligand for CW-10201 (HY-189305).