STING
Stimulator of Interferon Genes; TMEM173; MITA; ERIS; MPYS
Stimulator of interferon genes (STING) is an integral ER-membrane protein that can be activated by 2'3'-cGAMP synthesized by cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) upon binding of double-stranded DNA. It activates interferon (IFN) and inflammatory cytokine responses to defend against infection by microorganisms.
STING is a key cytosolic receptor for small nucleotides and plays a key role in anticancer and antiviral immunity. STING signaling pathway is also a critical link between innate and adaptive immunity, and induces anti-tumor immune responses. STING agonists, such as endogenous cyclic dinucleotide (CDN) cyclic GMP-AMP (cGAMP), have been used in diverse research for immunogenic tumor clearance, antiviral treatments and vaccine adjuvants.
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STING Inhibitors
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STING Agonists
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STING Antagonists
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STING Activators
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STING Modulators
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STING Degraders
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STING Controls
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STING Ligands
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STING Related Products (268)
Related Products (268)
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Antibodies (13)
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STING-IN-8
0 ImagesCat. No.: HY-163749STING-IN-8 (Compound 15b) emerges as a potent stimulator of interferon gene (STING) inhibitor with an IC50 value of 0.121 μM in human and an IC50 value of 0.033 μM in mouse. STING-IN-8 inhibits MSA-2 (HY-136927) or 2’, 3’ -cGAMP (HY-100564)-stimulated STING signaling and suppresses immune-inflammatory cytokine levels in both human and murine cells. STING-IN-8 is promising for research in the field of STING-associated inflammatory and autoimmune diseases.
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STING agonist-48
0 ImagesCat. No.: HY-178966CAS No.: 3027712-31-5STING agonist-48 is a potent STING agonist that exhibits STING-dependent activity in vitro (EC50 = 4.02 μM). STING agonist-48 prefers to bind with the transmembrane domain (TMD) over the cytosolic cyclic dinucleotide (CDN) domain. STING agonist-48 shows adjuvant efficacy, enhancing IgG and Th1/Th2 cytokine responses in humanized STING mice. STING agonist-48 can be used for the study of inflammation-related diseases.
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Berzosertib (Standard)
0 ImagesCat. No.: HY-13902RCAS No.: 1232416-25-9Synonyms: VE-822 (Standard); VX-970 (Standard); M6620 (Standard)Berzosertib (Standard) is the analytical standard of Berzosertib (HY-13902). This product is intended for research and analytical applications. Berzosertib (VE-822) is an orally active, CNS-penetrant, and selective ATR Kinase inhibitor. Berzosertib blocks ATR Kinase activity, abrogates G2/M cell cycle checkpoint, impairs DNA damage repair. Berzosertib induces apoptosis, inhibnits conlony migration, inhibits cell proliferation, and activates cGAS-STING axes in cancer cells. Berzosertib can be used for the research of cancers, such as head and neck squamous cell carcinoma, and colorectal cancer.
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MSA-2 (Standard)
0 ImagesCat. No.: HY-136927RCAS No.: 129425-81-6MSA-2 (Standard) is the analytical standard of MSA-2 (HY-136927). This product is intended for research and analytical applications. MSA-2, a potent and orally available non-nucleotide STING agonist, is bound to STING as a noncovalent dimer with nanomolar affinity. MSA-2 shows EC50s of 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively. MSA-2 stimulates interferon-β secretion in tumors, induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models.
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Vadimezan (Standard)
0 ImagesSynonyms: DMXAA (Standard); ASA-404 (Standard)Vadimezan (Standard) (DMXAA (Standard)) is the analytical standard of Vadimezan (HY-10964). This product is intended for research and analytical applications. Vadimezan (DMXAA; ASA-404), the tumor vascular disrupting agent (tumor-VDA), is a murine agonist of the stimulator of interferon genes (STING) and also a potent inducer of type I IFNs and other cytokines. Vadimezan is unable to activate human STING. Vadimezan has anti-influenza virus H1N1-PR8 activities.
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cGAMP (Standard)
0 ImagesCat. No.: HY-12512RCAS No.: 849214-04-6Synonyms: Cyclic GMP-AMP (Standard); 3',3'-cGAMP (Standard)cGAMP (Standard) is the analytical standard of cGAMP (HY-12512). This product is intended for research and analytical applications. cGAMP (Cyclic GMP-AMP) functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators.
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Omaveloxolone (Standard)
0 ImagesCat. No.: HY-12212RCAS No.: 1474034-05-3Synonyms: RTA 408 (Standard)Omaveloxolone (Standard) is the analytical standard of Omaveloxolone (HY-12212). This product is intended for research and analytical applications. Omaveloxolone (RTA 408) is an antioxidant inflammation modulator (AIM), which activates Nrf2 and suppresses nitric oxide (NO). Omaveloxolone attenuates osteoclastogenesis by inhibiting STING dependent NF-κb signaling.
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Ulevostinag (isomer 2)
0 ImagesCat. No.: HY-139586BCAS No.: 2082743-99-3Synonyms: MK-1454 (isomer 2)Ulevostinag isomer 2 (MK-1454 isomer 2) is the isomer of Ulevostinag. Ulevostinag is a STING agonist.
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STING agonist-3 (Standard)
0 ImagesSTING agonist-3 (Standard) is the analytical standard of STING agonist-3 (HY-103665). This product is intended for research and analytical applications. STING agonist-3, extracted from patent WO2017175147A1 (example 10), is a selective and non-nucleotide small-molecule STING agonist with a pEC50 and pIC50 of 7.5 and 9.5, respectively. STING agonist-3 has durable anti-tumor effect and tremendous potential to improve treatment of cancer.
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Anti-inflammatory agent 65
0 ImagesCat. No.: HY-149724CAS No.: 3035442-58-8Anti-inflammatory agent 65 (compound 29) is a Hederagonic acid derivative with potent anti-inflammatory activity. Anti-inflammatory agent 65 inhibits nitric oxide (NO) release. Anti-inflammatory agent 65 inhibits the nuclear translocation of IRF3 and p65, and disrupts the STING/IRF3/NF-κB signaling pathway, thereby attenuating the inflammatory response.
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E7766 diammonium salt (Standard)
0 ImagesCat. No.: HY-111999ARCAS No.: 2242635-03-4E7766 diammonium salt (Standard) is the analytical standard of E7766 (diammonium salt) (HY-111999A). This product is intended for research and analytical applications. E7766 diammonium salt is a macrocycle-bridged STING agonist with a Kd of 40 nM. E7766 diammonium salt shows potent pan-genotypic and antitumor activities.
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diABZI STING agonist-1 trihydrochloride (Standard)
0 ImagesCat. No.: HY-112921BRCAS No.: 2138299-34-8diABZI STING agonist-1 trihydrochloride (Standard) is the analytical standard of diABZI STING agonist-1 trihydrochloride (HY-112921B). This product is intended for research and analytical applications. diABZI STING agonist-1 (trihydrochloride) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.
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M04
0 ImagesCat. No.: HY-168384CAS No.: 875158-73-9M04 is an agonist of STING. It induces the expression of the IFN reporter gene in HEK293T cells expressing wild-type human STING, but does not induce this expression in HEK293T cells expressing the R71H-G230A-R293Q (HAQ) STING variant or in mouse RAW 264.7 cells, indicating that its activity is dependent on allelic and species variations. M04 induces the production of TNF-α, IL-10, IL-1β, and IL-12p70 in human peripheral blood mononuclear cells (PBMCs). At a concentration of 50 µM, M04 stimulates dendritic cells isolated from PBMCs to express the MHC class II cell surface receptor HLA-DR and co-stimulatory molecules CD40, CD80, and CD86, and also enhances their ability to activate T cells in an ex vivo assay. M04 can be used in research on inflammatory immune diseases.
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STING modulator-7
0 ImagesCat. No.: HY-163643CAS No.: 702662-64-4
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C-176 (Standard)
0 ImagesCat. No.: HY-112906RCAS No.: 314054-00-7C-176 (Standard) is the analytical standard of C-176 (HY-112906). This product is intended for research and analytical applications. C-176 is a selective and blood-brain barrier permeable STING inhibitor. C-176 covalently targets transmembrane cysteine residue 91 and thereby blocKing activation-induced palmitoylation of STING.
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H-151 (Standard)
0 ImagesCat. No.: HY-112693RCAS No.: 941987-60-6H-151 (Standard) is the analytical standard of H-151 (HY-112693). This product is intended for research and analytical applications. H-151 is a potent, selective and covalent antagonist of STING that has noteworthy inhibitory activity both in cells and in vivo. H-151 reduces TBK1 phosphorylation and suppresses STING palmitoylation. H-151 can be used for the research of autoinflammatory disease.
