Sigma Receptor
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Sigma Receptor Related Products (108)
Related Products (108)
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S1R agonist 1 hydrochloride
0 ImagesS1R agonist 1 (Compound 6b) hydrochloride is a selective S1R agonist with Kis of 0.93 nM and 72 nM for S1R and S2R, respectively. S1R agonist 1 hydrochloride exhibits neuroprotection against ROS and NMDA-induced neurotoxicity.
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KB-5492 anhydrous
0 ImagesKB-5492 anhydrous is a potent and selective inhibitor of sigma receptor, inhibits specific [3H]1,3-di(2-tolyl)guanidine (DTG) binding to the sigma receptor with an IC50 of 3.15 μM. KB-5492 anhydrous is an anti-ulcer agent.
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Sigmar1 Mouse Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS12909Sigmar1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sigmar1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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EST73502 monohydrochloride
0 ImagesEST73502 monohydrochloride is a selective, orally active and blood-brain barrier (BBB) penetrant dual μ-opioid receptor (MOR) agonist and σ1 receptor (σ1R) antagonist, with Kis of 64 nM and 118 nM for MOR and σ1R, respectively. EST73502 monohydrochloride has antinociceptive activity.
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Sigma ligand-1
0 ImagesSigma ligand-1 is a selective sigma receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively. Sigma ligand-1 has a Ki of 4000 nM at the dopamine D2 receptor.
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SR-31747 free base
0 ImagesCat. No.: HY-13751ACAS No.: 132173-06-9SR-31747 free base is a sigma ligand with immunosuppressive and anti-inflammatory properties. SR-31747 blocks cell proliferation by inhibiting sterol isomerase.
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Ditolylguanidine (Standard)
0 ImagesSynonyms: 1,3-Di-o-tolylguanidine (Standard); DTG (Standard)Ditolylguanidine (Standard) is the analytical standard of Ditolylguanidine. This product is intended for research and analytical applications. Ditolylguanidine (1,3-Di-o-tolylguanidine) is an agonist of sigma receptor (σ1/σ2 receptor) with Ki values of 69 and 21 nM for σ1 and σ2 receptors, respectively. Ditolylguanidine effectively inhibits the growth of small cell lung cancer cells. Ditolylguanidine can be used for the research of lung cancer.
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BD-1008-d5 dihydrobromide
0 ImagesCat. No.: HY-100966SBD-1008-d5 dihydrobromide is the deuterium labeled BD-1008 dihydrobromide (HY-100966). BD-1008 dihydrobromide is a nonselective σ receptor antagonist with Kis against σ1 receptor and σ2 receptor of 2 nM and 8 nM. The BD-1008 dihydrobromide has an extremely low affinity for the D2 receptor (Ki = 1112 nM) and dopamine transporter (DAT) (Ki > 10,000 nM). BD-1008 dihydrobromide significantly antagonizes dopamine release in the shell region of the nucleus accumbens via the σ₂ receptor. BD-1008 dihydrobromide blocks the self-administration behavior of σ agonists.BD-1008 dihydrobromide can be used for the study of addiction therapy that target the σ receptor.
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BD-1063-d8 dihydrochloride
0 ImagesCat. No.: HY-18101SCAS No.: 1246819-69-1BD-1063-d8 dihydrochloride is the deuterium labeled BD1063 dihydrochloride (HY-18101A). BD-1063 dihydrochloride is a selective σ-1 receptor antagonist with inhibitory activity against TRPC5 and TRPM3. BD-1063 dihydrochloride exerts anti-hyperalgesic and anti-allodynic effects by inhibiting sustained calcium influx mediated by TRPC5 and TRPM3, and reverses the effects of Carrageenan (HY-125474). BD-1063 dihydrochloride also significantly reduces excessive ethanol self-administration behavior. BD-1063 dihydrochloride is widely used in studies on the mechanisms underlying neuropathic pain, inflammatory hyperalgesia, and alcohol abuse and dependence.
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Umespirone
0 ImagesCat. No.: HY-123408CAS No.: 107736-98-1Synonyms: KC 9172Umespirone (KC 9172) is a potential antipsychotic/antianxiety agent.
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Siramesine fumarate
0 ImagesCat. No.: HY-14221BCAS No.: 163630-79-3Synonyms: LU-28-179 fumarateSiramesine (Lu 28-179) fumarate is a potent sigma-2 receptor agonist. Siramesine fumarate has a subnanomolar affinity for sigma-2 receptors (IC50=0.12?nM) and exhibits a 140-fold selectivity for sigma-2 receptors over sigma-1 receptors (IC50=17?nM). Siramesine fumarate triggers cell death through destabilisation of mitochondria, but not lysosomes. Anti-cancer activity.
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SYB4
0 ImagesCat. No.: HY-163075CAS No.: 2101953-60-8SYB4 (compound 5) is a PET tracer which suitable for imaging the Sigma-2 Receptor in the brain of nonhuman primates.
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RC-106
0 ImagesCat. No.: HY-158197CAS No.: 1346216-50-9RC-106 is a proteasome inhibitor (IC50: 35 μM) and Sigma receptor modulator with anticancer activity. RC-106 has antiproliferative activity against cancer cells including glioblastoma (GB) and multiple myeloma (MM).
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SAS-0132
0 ImagesCat. No.: HY-119386CAS No.: 1644629-60-6SAS-0132 is a selective Sigma 2 receptor (Sig2R) antagonist (Ki: 90 nM) that can cross the blood-brain barrier. SAS-0132 is capable of regulating intracellular Ca2+ levels and modulating PGRMC1-related pathways. SAS-0132 exhibits neuroprotective activity and can improve cognitive impairment in Alzheimer's disease mice. SAS-0132 can be used in the research of neurocognitive disorders such as Alzheimer's disease.
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CM304
0 ImagesCat. No.: HY-129485CAS No.: 1417742-48-3Synonyms: FTC-146 hydrochlorideCM304 is a potent S1R inhibitor that can inhibit drug-induced convulsions in rats.
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σ1 Receptor/μ Opioid receptor modulator 1
0 ImagesCat. No.: HY-147560CAS No.: 2412700-00-4σ1 Receptor/μ Opioid receptor modulator 1 (Compound 44) is a potent σ1 receptor antagonist and μ opioid receptor agonist with Kis of 1.86 nM and 2.1 nM, respectively.σ1 Receptor/μ Opioid receptor modulator 1 exhibits potent analgesic activity. σ1 Receptor/μ Opioid receptor modulator 1 can be used for the research of neuropathic pain.
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KSCM-11
0 ImagesCat. No.: HY-121867CAS No.: 1415247-16-3KSCM-11 is a ligand of thesigma receptor.
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L-693403 maleate
0 ImagesCat. No.: HY-100930CAS No.: 207455-21-8L-693403 maleate is a high affinity and selective σ ligand. L-693403 maleate has the potential for physiological disease research.
