ALK5

By Type:	Pan (12) Selective (8)

Cat. No.	Product Name	Effect	Purity

HY-10431

SB-431542	Inhibitor	99.89%
SB-431542 is a TGF-β receptor kinase inhibitor (TRKI).

HY-10432

A 83-01	Inhibitor	99.08%
A 83-01 is a potent inhibitor of TGF-β type I receptor ALK5 kinase, type I nodal receptor ALK4 and type I nodal receptor ALK7, with IC₅₀s of 12 nM, 45 nM and 7.5 nM against the transcription induced by ALK5, ALK4 and ALK7, respectively.

HY-13012

RepSox	Inhibitor	99.93%
RepSox (E-616452) is a potent and selective transforming growth factor-beta receptor I/activin like kinase 5 (TGF-β-RI/ALK5) inhibitor.

HY-10432A

A 83-01 sodium	Inhibitor
A 83-01 sodium is a potent inhibitor of TGF-β type I receptor ALK5 kinase, ALK4 and ALK7, with IC₅₀s of 12 nM, 45 nM and 7.5 nM against the transcription induced by ALK5, ALK4 and ALK7, respectively.

HY-19928

Vactosertib	Inhibitor	99.58%
Vactosertib (EW-7197) is a potent, orally active and ATP-competitive activin receptor-like kinase 5 (ALK5) inhibitor with an IC₅₀ of 12.9 nM.

HY-10431G

SB-431542 (GMP)	Inhibitor
SB-431542 (GMP) is SB-431542 (HY-10431) produced by using GMP guidelines.

HY-150169

THRX-144644	Inhibitor
THRX-144644 is a Lung-restricted ALK5 inhibitor with an IC₅₀ value of 0.14 nM.

HY-15897

LDN-212854	Inhibitor	99.70%
LDN-212854 is a bone morphogenetic protein (BMP) inhibitor that potently inhibits ALK2 (IC₅₀: 1.3 nM).

HY-19928A

Vactosertib Hydrochloride	Inhibitor	99.09%
Vactosertib Hydrochloride (EW-7197 Hydrochloride) is a potent, orally active and ATP-competitive activin receptor-like kinase 5 (ALK5) inhibitor with an IC₅₀ of 12.9 nM.

HY-18758

IN-1130	Inhibitor	99.79%
IN-1130 is a highly selective transforming growth factor-β type I receptor kinase (ALK5) inhibitor with an IC₅₀ of 5.3 nM for ALK5-mediated Smad3 phosphorylation.

HY-12953

R-268712	Inhibitor	99.78%
R-268712 is an orally active and selective ALK-5 inhibitor, with an IC₅₀ of 2.5 nM.

HY-109179

Itacnosertib	Inhibitor	99.77%
Itacnosertib (TP-0184) is both inhibitor to JAK2, ACVR1 (ALK2) and ALK5 as described in WO2014151871.

HY-18766

EW-7195	Inhibitor	99.20%
EW-7195 is a potent and selective ALK5 (TGFβR1) inhibitor with an IC₅₀ of 4.83 nM.

HY-151289

ALK5-IN-34	Inhibitor
ALK5-IN-34 is an selective orally active activin receptor-like kinase (ALK) inhibitor.

HY-151283

ALK5-IN-33	Inhibitor
ALK5-IN-33 (Compound EX-10) is a selective, orally active ALK-5 inhibitor with an IC₅₀ ≤10 nM.

HY-123900

AZ12799734	Inhibitor
AZ12799734 is a selective, orally active TGFBR1 kinase inhibitor with an IC₅₀ of 47 nM.

HY-151270

ALK5-IN-25	Inhibitor
ALK5-IN-25 (compound EX-02) is a potent ALK-5 inhibitor with an IC₅₀ ≤10 nM.

HY-151273

ALK5-IN-27	Inhibitor
ALK5-IN-27 (Compound EX-04) is a potent ALK-5 inhibitor with an IC₅₀ ≤10 nM.

HY-145855

J-1063	Inhibitor
J-1063 is a potent, selective and orally active ALK5 inhibitor with an IC₅₀ of 0.039 µM.

HY-151275

ALK5-IN-28	Inhibitor
ALK5-IN-28 (compound Ex-05) is a selective ALK-5 inhibitor (IC₅₀≤10 nM), inhibits TGF-β-induced SMAD signaling.

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ALK5 Related Products (20)