2. Signaling Pathways
  3. Autophagy
  4. ULK

ULK

Unc-51 like kinase

ULK

Related Products

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The ULK (UNC51-like) enzymes are a family of mammalian kinases that have critical roles in autophagy and development. The ULK family of kinases comprises 5 genes in mammals: ULK1 through ULK4 and STK36. In mammals, ULK1 and ULK2 have been shown to be necessary for the proper autophagy induction and contribute to various developmental, physiological, and pathological processes.

The serine/threonine-protein kinases ULK1 and ULK2 are evolutionarily conserved serine/threonine kinase orthologs of the yeast autophagy related (Atg) family member Atg1, that have redundant roles in the regulation of autophagy. Autophagy targets long-lived proteins or organelles for degradation in lysosomes, and the products of this process are then recycled for other cellular pathways. The canonical ULK/Atg1 complex is composed of ULK1, ATG13, RB1CC1/FIP200/ATG17, and ATG101. It initiates autophagosome formation, at least in part by phosphorylating components of the autophagy-inducing class III phosphatidylinositol 3-kinase complex (e.g., PI3K3C/Vps34, PIK3R4/Vps15, BECN1/Vps30/ATG6, ATG14). ULK/Atg1 also promotes membrane recycling via ATG9. Consistent with the established role of ULK1/2 in autophagy, disrupting ULK1 expression in mice results in a defect in autophagy-mediated clearance of mitochondria during red blood cell maturation, and mice lacking both ULK1 and ULK2 expression die shortly after birth due to a defect in glycogen metabolism, which is similar to other autophagy-defective mice.

ULK Isoform Specific Products:

ULK Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-148063
    DB0614
    DB0614 is a PROTAC based on Cereblon ligand, which is a selective and potent targeted protein degrader of NEK9 inhibitor. DB0614 can degrade ABL1, ABL2, BLK, CDK11B, CDK4, CSK, EPHA3, FER, GAK, LIMK1, MAP3K20, MAP4K1, MAP4K2, MAP4K3, MAP4K5, MAPK14, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, NLK, PDIK1L, PTK2B, RIPK1, RPS6KA1, RPS6KA3, SIK2, SIK3, STK35, TNK2 and ULK1. DB0614 can be used for research of disease or disorder mediated by aberrant kinase activity.(Blue: Thalidomide-4-OH (HY-103596), Black: linker, Pink: FLT3-IN-17 (HY-148070))
    DB0614
  • HY-RS15451
    ULK1 Human Pre-designed siRNA Set A
    		Inhibitor

    ULK1 Human Pre-designed siRNA Set A contains three designed siRNAs for ULK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    ULK1 Human Pre-designed siRNA Set A
  • HY-101923A
    LYN-1604 hydrochloride
    		Activator
    LYN-1604 hydrochloride is a potent UNC-51-like kinase 1 (ULK1) activator (EC50=18.94 nM) for the research of triple negative breast cancer (TNBC).
    LYN-1604 hydrochloride
  • HY-13018A
    MRT67307 hydrochloride
    		Inhibitor
    MRT67307 hydrochloride is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively. MRT67307 hydrochloride also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 hydrochloride also blocks autophagy in cells.
    MRT67307 hydrochloride
  • HY-162100
    MR-2088
    		Inhibitor 99.50%
    MR-2088 is a reversible, ATP-competitive, and selective ULK1/2 inhibitor with pEC50 values of 8.3 and 8.7 respectively. MR-2088 effectively inhibits autophagic flux and demonstrates a synergistic antiproliferative effect with Trametinib (HY-10999) (MEK inhibitor) in vitro. MR-2088 can be used for non-small lung cell cancer (NSCLC) research.
    MR-2088
  • HY-N0867
    13-Oxyingenol-13-dodecanoate
    		Inducer 99.37%
    13-Oxyingenol-dodecanoate (13OD) is a tumor suppressor agent. 13-Oxyingenol-dodecanoate has anti-HIV-1 activity with EC50 value of 33.7 nM.13-Oxyingenol-dodecanoate can induce the expression of ULK1 to effect mitochondrial dysfunction and cellular autophagy. 13-Oxyingenol-dodecanoate also increases the expression of BAX and suppresses the expression of BCL-2 to effect apoptosis.
    13-Oxyingenol-13-dodecanoate
  • HY-RS15452
    Ulk1 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Ulk1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ulk1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Ulk1 Mouse Pre-designed siRNA Set A
  • HY-RS15454
    ULK2 Human Pre-designed siRNA Set A
    		Inhibitor

    ULK2 Human Pre-designed siRNA Set A contains three designed siRNAs for ULK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    ULK2 Human Pre-designed siRNA Set A
  • HY-115570A
    (Z/E)-GW406108X
    		Inhibitor
    (Z/E)-GW406108X is a mixture of different configurations of GW406108X (HY-115570). GW406108X is a specific Kif15 (Kinesin-12) inhibitor with an IC50 of 0.82 uM.
    (Z/E)-GW406108X
  • HY-13018B
    MRT67307 dihydrochloride
    		Inhibitor
    MRT67307 dihydrochloride is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively. MRT67307 dihydrochloride also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 dihydrochloride also blocks autophagy in cells.
    MRT67307 dihydrochloride
  • HY-100006B
    MRT68921 hydrochloride
    		Inhibitor
    MRT68921 hydrochloride is a potent NUAK1/ULK1 dual inhibitor. MRT68921 hydrochloride inhibits ULK1 and ULK2 with IC50 values of 2.9 nM and 1.1 nM, respectively. MRT68921 hydrochloride can block cells autophagy and kill tumor cells by breaking the balance of oxidative stress signals. MRT68921 hydrochloride can inhibit cell proliferation and induce ROS production and apoptosis. MRT68921 hydrochloride can be used for the research of cancer, such as breast cancer.
    MRT68921 hydrochloride
  • HY-E70875
    ULK1 Recombinant Human Active Protein Kinase
    ULK1 (unc-51 like autophagy activating kinase 1), one of the core human autophagy-related genes, encodes a serine-threonine kinase and the mammalian ortholog of the yeast ATG1 gene. ULK1 Recombinant Human Active Protein Kinase is a recombinant ULK1 protein that can be used to study ULK1-related functions.
    ULK1 Recombinant Human Active Protein Kinase
  • HY-161850
    ULK1-IN-3
    		Inhibitor
    ULK1-IN-3 (Compound 8) is a novel chromone-based as a potential inhibitor of ULK1. ULK1-IN-3 inhibits cell cycle, autophagy and induces apoptosis, oxidative stress in colon cancer cell lines.
    ULK1-IN-3
  • HY-158408
    NZ-66
    NZ-66 is a UNC-51-like kinase 1 (ULK1) targeting chimera, which is used to achieve proximity-induced and ULK1-dependent degradation of mitochondria. NZ-66 induces mitophagy. NZ-66 is potential for attenuating neurodegenerative disorders.
    NZ-66
  • HY-RS15455
    Ulk2 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Ulk2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ulk2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Ulk2 Mouse Pre-designed siRNA Set A
  • HY-125199
    ULK-100
    		Inhibitor
    ULK-100 is a highly selective and potent ULK1 kinase inhibitor with an IC50 value of 1.6 nM. ULK-100 is promising for research of autophagy-related diseases (e.g., KRAS-mutant lung cancer, glioblastoma).
    ULK-100
  • HY-181699
    ULK1-IN-5
    		Inhibitor
    ULK1-IN-5 (Compound D1) is a selective ULK1 inhibitor with an IC50 of 14.91 nM. ULK1-IN-5 functionally inhibits the kinase activity of ULK1. ULK1-IN-5 reduces the phosphorylation level of ATG13. ULK1-IN-5 exerts antiproliferative effects on cervical cancer cells. ULK1-IN-5 is applicable to relevant research on cervical cancer.
    ULK1-IN-5
  • HY-181815
    SBP-5147
    		Inhibitor
    SBP-5147 is an orally active ULK1/ULK2 inhibitor, with an IC50 of 2 nM against ULK1 and an IC50 of 53 nM against ULK2. SBP-5147 inhibits the phosphorylation of Beclin-1 and Vps34, reduces autophagy flux, downregulates the expression of ATG13 and ATG101, upregulates the expression of MHC-I, induces caspase-dependent apoptosis, and decreases the viability of non-small cell lung cancer cells. SBP-5147 is applicable to research related to non-small cell lung cancer[1].
    SBP-5147
  • HY-101923R
    LYN-1604 (Standard)
    		Activator
    LYN-1604 (Standard) is the analytical standard of LYN-1604 (HY-101923). This product is intended for research and analytical applications. LYN-1604 is a potent UNC-51-like kinase 1 (ULK1) activator (EC50=18.94 nM) for the research of triple negative breast cancer (TNBC).
    LYN-1604 (Standard)
  • HY-100006AR
    MRT68921 dihydrochloride (Standard)
    		Inhibitor
    MRT68921 (dihydrochloride) (Standard) is the analytical standard of MRT68921 (dihydrochloride) (HY-100006A). This product is intended for research and analytical applications. MRT68921 dihydrochloride is a potent NUAK1/ULK1 dual inhibitor. MRT68921 dihydrochloride inhibits ULK1 and ULK2 with IC50 values of 2.9 nM and 1.1 nM, respectively. MRT68921 dihydrochloride can block cells autophagy and kill tumor cells by breaking the balance of oxidative stress signals. MRT68921 dihydrochloride can inhibit cell proliferation and induce ROS production and apoptosis. MRT68921 dihydrochloride can be used for the research of cancer, such as breast cancer.
    MRT68921 dihydrochloride (Standard)
Cat. No. Product Name / Synonyms Application Reactivity
ULK Isoform Comparison

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