2497409-01-3
2497409-01-3
Chemical Structure
ULK1-IN-2
- CAS No.: 2497409-01-3
- Formula:C19H16BrFN4O6
- Molecular Weight:495.26
IUPAC Name: 5-bromo-4-(2-fluoro-4-nitrophenoxy)-N-(3,4,5-trimethoxyphenyl)pyrimidin-2-amine
InChIKey: CVOMZGNACQPPDA-UHFFFAOYSA-N
SMILES: COC1=C(OC)C(OC)=CC(NC2=NC=C(Br)C(OC3=CC=C([N+]([O-])=O)C=C3F)=N2)=C1
Biological Activity: ULK1-IN-2 (compound 3s) is a potent ULK1 inhibitor. ULK1-IN-2 shows highest cytotoxic effect against cancer cell lines, with IC50 of 1.94 μM in A549. ULK1-IN-2 can induce apoptosis and simultaneously block autophagy, and can be used to study NSCLC (Non-small cell lung cancer)[1].
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ULK1-IN-2 | 98.34% | ULK1-IN-2 (compound 3s) is a potent ULK1 inhibitor. ULK1-IN-2 shows highest cytotoxic effect against cancer cell lines, with IC50 of 1.94 μM in A549. ULK1-IN-2 can induce apoptosis and simultaneously block autophagy, and can be used to study NSCLC (Non-small cell lung cancer). | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.70
HY-16966SBI-0206965 -
Similarity Score 0.56
HY-180292Tubulin/VEGFR-2-IN-2 -
Similarity Score 0.55
HY-117595PHM16 -
Similarity Score 0.53
HY-122186SGC-GAK-1 -
Similarity Score 0.53
HY-124793AGAK inhibitor 49 hydrochloride -
Similarity Score 0.53
HY-124793GAK inhibitor 49 -
Similarity Score 0.53
HY-157553FAK-IN-19 -
Similarity Score 0.53
HY-111378Casein Kinase II Inhibitor IV -
Similarity Score 0.53
HY-111378ACasein Kinase II Inhibitor IV hydrochloride -
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