2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Amino acid Transporter

Amino acid Transporter

氨基酸转运蛋白

Amino acid transporters are a class of membrane proteins responsible for transporting amino acids between the inside and outside of cells, crucial for maintaining the balance of amino acid concentrations. The SLC3 and SLC7 families are two well-studied classes of amino acid transporters. The SLC7 family includes cationic amino acid transporters (CATs) and L-type amino acid transporters (LATs), with LATs typically forming heterodimeric complexes with the heavy chain subunits of the SLC3 family through disulfide bonds, known as heteromeric amino acid transporters (HATs).
Amino acid transporters are involved in regulating intracellular signaling pathways such as the mammalian target of rapamycin complex 1 (mTORC1) and the general control non-derepressible (GCN) pathways, influencing protein synthesis, cell proliferation, and growth through the regulation of these signaling pathways. Dysfunctions in amino acid transporters are associated with diseases such as hereditary aminoaciduria, tumor growth, and absorption disorders in the intestines and kidneys. Specific transporters, like LAT1 and SLC7A5, play crucial roles in the proliferation and metabolism of tumor cells and can serve as potential drug targets[1][2].

Amino acid Transporter Related Products (26):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-181753
    INSP-0154
    INSP-0154 is a potent creatine kinase B (CKB)/creatine transporter (SLC6A8) inhibitor. INSP-0154 binds to the SLC6A8 occluded pocket, prevents creatine transport into cells, and protects SLC6A8 cysteine residue C144 from irreversible inactivation. INSP-0154 inhibits creatine uptake in mouse heart tissue. INSP-0154 can be used for the research of cancer.
    INSP-0154
  • HY-113745
    LX-6171
    		Inhibitor
    LX-6171 is an orally active SLC6A7 inhibitor. LX-6171 can be used to study diseases characterized by cognitive impairment, such as Alzheimer's disease, schizophrenia or vascular dementia.
    LX-6171
  • HY-176873
    SLC6A19-IN-2
    		Inhibitor
    SLC6A19-IN-2 (Example 4) is a potent SLC6A19 inhibitor with an IC50 of 14 nM. SLC6A19-IN-2 can be used for the study of metabolic diseases such as nonalcoholic steatohepatitis (NASH), nonalcoholic fatty liver disease (NAFLD) and phenylketonuria (PKU).
    SLC6A19-IN-2
  • HY-134452R
    MeAIB (Standard)
    MeAIB (Standard) is the analytical standard of MeAIB. This product is intended for research and analytical applications. MeAIB (α-(Methylamino)isobutyric acid) is a specific substrate for amino acid transport system A (ATA1). ATA mediate the uptake of short-chain neutral amino acids in a Na+-dependent manner.
    MeAIB (Standard)
  • HY-W246010
    α,α-DiBn-DL-Gly
    		Inhibitor
    α,α-DiBn-DL-Gly (Dibenzylglycine) is an achiral α-substituted phenylalanine derivative, non-substrate weak inhibitor of LAT1 (L-type amino acid transporter 1). α,α-DiBn-DL-Gly does not stimulate efflux of-Gabapentin from preloaded HEK-hLAT1 cells. α,α-DiBn-DL-Gly shows minimal inhibition of-Gabapentin (HY-A0057) uptake into HEK-hLAT1 cells.
    α,α-DiBn-DL-Gly
  • HY-179689
    SLC6A19-IN-5
    		Inhibitor
    SLC6A19-IN-5 (Example 25) is a SLC6A19 inhibitor with an IC50 of 11 nM. SLC6A19-IN-5 can be used for research on diseases related to abnormal amino acid metabolism, amino acid transport, and/or amino acid levels.
    SLC6A19-IN-5