Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
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Drug Derivative Inhibitors
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Drug Derivative Related Products (4062)
Related Products (4062)
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Hericenone A
0 ImagesCat. No.: HY-N15388CAS No.: 126654-52-2
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Rehmannioside B
0 ImagesCat. No.: HY-N10694CAS No.: 81720-06-1Rehmannioside B is an iridoid compound that can be found in the root tuber of Rehmannia glutinosa Libosch, stem bark and root of Feretia apodanthera.
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Jaconine N-oxide
0 ImagesCat. No.: HY-N20655CAS No.: 1148039-75-1Jaconine N-oxide is a dechlorination product of Jacobine N-oxide (HY-N9511).
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4-((Carboxymethyl)amino)benzoic acid
0 ImagesCat. No.: HY-W614122CAS No.: 5698-54-4Synonyms: 4-COOH-Hippuric acid; 4-[(Carboxymethyl)amino]benzoic acid4-((Carboxymethyl)amino)benzoic acid (4-COOH-Hippuric acid) is a derivative of 4-Aminobenzoic acidchorismate (PABA) (HY-B1008). 4-((Carboxymethyl)amino)benzoic acid is a competitive inhibitor of 4-Amino-4-deoxychorismate synthase.
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Piperidione
0 ImagesCat. No.: HY-W181871CAS No.: 77-03-2Piperidione is a cough agent.
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3A-Amino-3A-deoxy-(2AS,3AS)-γ-cyclodextrin
0 ImagesCat. No.: HY-W145571CAS No.: 189307-64-0Synonyms: 3A-Amino-3A-deoxy-(2AS,3AS)-gamma-cyclodextrin3A-Amino-3A-deoxy-(2AS,3AS)-gamma-cyclodextrin is a derivative of γ-Cyclodextrin (HY-W040040).
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Dihydromunduletone (Standard)
0 ImagesCat. No.: HY-101483RCAS No.: 674786-20-0Dihydromunduletone (Standard) is the analytical standard of Dihydromunduletone (HY-101483). This product is intended for research and analytical applications. Dihydromunduletone (DHM) is a rotenoid derivative and a selective, potent adhesion G protein-coupled receptor (aGPCR) (GPR56 and GPR114/ADGRG5) antagonist with an IC 50 of 20.9 μM for GPR56, but not inhibit GPR110 or class A GPCRs.
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25G-NBOMe hydrochloride
0 ImagesCat. No.: HY-135448CAS No.: 1797132-54-725G-NBOMe hydrochloride is a derivative of 2,5-phenethylamines, characterized by the addition of a benzyl-methoxy (BOMe) group to the amine.
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N,N-dimethyl-N'-p-tolylsulfamide
0 ImagesCat. No.: HY-W286414CAS No.: 66840-71-9Synonyms: DMSTN,N-dimethyl-N'-p-tolylsulfamide (DMST) is a hydrolysis product of Tolylfluanid (HY-W774955). The photodegradation rate of N,N-dimethyl-N'-p-tolylsulfamide in coastal seawater is higher than that in seawater or deionized water.
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Norjuziphine
0 ImagesCat. No.: HY-N10337CAS No.: 74119-87-2Synonyms: (-)-NorjuziphineNorjuziphine ((-)-Norjuziphine) is an alkaloid found in the lotus flower (Nelumbo nucifera). Norjuziphine inhibits the melanogenesis of murine B16 melanoma 4A5 cells stimulated by Theophylline (HY-B0809) (IC50=14.4 μM). Norjuziphine is promising for research of skin whitening and related skin pigmentation diseases.
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Bosutinib N-Oxide
0 ImagesCat. No.: HY-W770773CAS No.: 2468737-96-2Bosutinib N-Oxide (Compound 80) is a quinoline-type heterocyclic compound. Bosutinib N-Oxide shows anti-proliferative activity and can be used for research of leukemia.
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Zibrofusidic acid
0 ImagesCat. No.: HY-156921CAS No.: 827603-95-2Synonyms: 24-Bromofusidic acid; TD-1414Zibrofusidic acid (24-Bromofusidic acid; TD-1414) is a brominated derivative of Fusidic acid (HY-B1350). Zibrofusidic acid can be combined within the hydrophobic groove formed by the transmembrane helix 1 (TM1) and the transmembrane helix 2 (TM2) of the AcrB protein. Zibrofusidic acid can be used for the research of multidrug efflux pump.
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6'Nicotinate Ac4ManNAz
0 ImagesCat. No.: HY-177738CAS No.: 2102591-12-66'Nicotinate Ac4ManNAz (Compound 2) is a brain-penetrant carbohydrate-neuroactive heteromer conjugating Ac4ManNAz (HY-W728531) and Nicotinic acid (HY-B0143). 6'Nicotinate Ac4ManNAz can be used for the development of glycosylation-regulating agents or diagnostic probes that cross the BBB.
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4-Trehalosamine
0 ImagesCat. No.: HY-N15182CAS No.: 51855-99-34-Trehalosamine is a derivative of trehalose with weak antibacterial activity. 4-Trehalosamine shows no toxic effects when injected intravenously into mice at a dose of 625 mg/kg.
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N-Propyl buphedrone hydrochloride
0 ImagesCat. No.: HY-W719011CAS No.: 18267-91-9N-Propyl buphedrone hydrochloride is a drug derivative.
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(±)-Threo-Isopropylphenidate hydrochloride
0 ImagesCat. No.: HY-138873CAS No.: 1262795-94-7(±)-Threo-Isopropylphenidate hydrochloride is structurally categorized as a phenethylamine.
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N-Mitrososarcosine
0 ImagesCat. No.: HY-W188178CAS No.: 13256-22-9
