mAChR
Muscarinic acetylcholine receptor
mAChRs (muscarinic acetylcholine receptors) are acetylcholine receptors that form G protein-receptor complexes in the cell membranes of certainneurons and other cells. They play several roles, including acting as the main end-receptor stimulated by acetylcholine released from postganglionic fibersin the parasympathetic nervous system. mAChRs are named as such because they are more sensitive to muscarine than to nicotine. Their counterparts are nicotinic acetylcholine receptors (nAChRs), receptor ion channels that are also important in the autonomic nervous system. Many drugs and other substances (for example pilocarpineand scopolamine) manipulate these two distinct receptors by acting as selective agonists or antagonists. Acetylcholine (ACh) is a neurotransmitter found extensively in the brain and the autonomic ganglia.
mAChR Isoform Specific Products
All Product Categories
-
mAChR Inhibitors
(115)
View all products
-
mAChR Agonists
(149)
View all products
-
mAChR Antagonists
(323)
View all products
-
mAChR Activators
(20)
View all products
-
mAChR Modulators
(48)
View all products
-
mAChR Inducer
(1)
View all products
-
mAChR Controls
(9)
View all products
-
mAChR Ligands
(10)
View all products
-
Productos relacionados con mAChR (727)
Productos relacionados con (727)
-
Antibodies (2)
-
mAChR Isoform Comparison
-
Anethole trithione (Standard)
0 ImagesAnethole trithione (Standard) is the analytical standard of Anethole trithione. This product is intended for research and analytical applications. Anethole trithione, a sulfur heterocyclic choleretic, is a bile secretion-stimulating agent. Anethole trithione enhances salivary secretion and increases mAChRs, and can be used for dry mouth research.
-
Otilonium bromide (Standard)
0 ImagesSynonyms: Octylonium bromide (Standard); SP63 (Standard)Otilonium (bromide) (Standard) is the analytical standard of Otilonium (bromide). This product is intended for research and analytical applications. Otilonium bromide (OB) is an orally active mAChR inhibitor and smooth muscle relaxant which can interfere with the mobilization of calcium in intestinal smooth muscle, OB can be used for research of irritable bowel syndrome.
-
Velufenacin (Standard)
0 ImagesReferencia número: HY-109196RNo. CAS: 1648737-78-3Synonyms: DA-8010 (Standard)Velufenacin (Standard) is the analytical standard of Velufenacin (HY-109196). This product is intended for research and analytical applications. Velufenacin is a muscarinic receptor antagonist.
-
SCH 211803
0 ImagesReferencia número: HY-171449No. CAS: 331765-50-5SCH 211803 is a selective antagonist of the M2 muscarinic receptor. SCH 211803 is promising for research of cardiovascular and nervous system diseases.
-
Pentoxyverine (Standard)
0 ImagesSynonyms: Carbetapentane (Standard)Pentoxyverine (Standard) is the analytical standard of Pentoxyverine. This product is intended for research and analytical applications. Pentoxyverine (Carbetapentane) is an orally active sigma-1 receptor agonist, with Kis of 41 nM, 894 nM and 75 nM for σ1, σ2 and guinea-pig brain membran σ1, respectively. Pentoxyverine is a muscarinic antagonist. Pentoxyverine is a potent antitussive, anticonvulsant, and spasmolytic agent. Pentoxyverine can be used for inhibiting bronchial interceptor, weakening of cough reflex, bronchial smooth muscle relaxation and reduction of airway resistance.
-
Zamifenacin fumarate (Standard)
0 ImagesSynonyms: UK-76654 fumarate (Standard)Zamifenacin fumarate (Standard) is the analytical standard of Zamifenacin (fumarate) (HY-107649). This product is intended for research and analytical applications. Zamifenacin fumarate (UK-76654 fumarate) is a potent gut-selective muscarinic M3 receptor antagonist. Zamifenacin significantly reduces colonic motility in irritable bowel syndrome.
-
Imidafenacin (Standard)
0 ImagesSynonyms: KRP-197 (Standard); ONO-8025 (Standard)Imidafenacin (KRP-197; ONO-8025) is an orally active inhibitor of muscarinic (mAChR) M1 and M3 receptors. Imidafenacin potently inhibits bladder contraction in vivo and exerts an antidiuretic effect by enhancing the signaling pathway of vasopressin (antidiuretic hormone). Imidafenacin can be used in research related to overactive bladder.
-
WIN 62577
0 ImagesReferencia número: HY-169501No. CAS: 138091-43-7WIN 62577 is a species-selective tachykinin NK1 receptor antagonist. WIN 62577 is also an allosteric enhancer with micromolar potency at M3 receptors. WIN 62577 exhibits potent antiviral activity against SARS-CoV-2.
-
Cyclopentolate
0 ImagesCyclopentolate (DL-Cyclopentolate) is an Atropine-like muscarinic receptors antagonist with a pKB value of 7.8 (on the circular ciliary muscle). Cyclopentolate is an anti-muscarinic agent commonly used in the ophthalmologic practice.
-
(Rac)-5-Carboxy tolterodine
0 ImagesReferencia número: HY-W700319No. CAS: 1076199-77-3(Rac)-5-Carboxy tolterodine is an inactive metabolite of the muscarinic acetylcholine receptor antagonist Tolterodine (HY-A0024).
-
Irsogladine maleate
0 ImagesSynonyms: Dicloguamine maleate; MN1695Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder.
-
(R)-Oxybutynin-d10
0 ImagesReferencia número: HY-B0267CSNo. CAS: 1189190-67-7Synonyms: Aroxybutynin-d10(R)-Oxybutynin-d10 (Aroxybutynin-d10) is deuterium labeled (R)-Oxybutynin. (R)-Oxybutynin (Aroxybutynin) is the racemic isomer of Oxybutynin and an orally active muscarinic receptor antagonist. (R)-Oxybutynin has antispasmodic, antimuscarinic, and anticholinergic activities and competitively antagonizes carbachol-induced contractions. (R)-Oxybutynin can be used to study urinary incontinence caused by neurogenic bladder dysfunction.
-
SCH 57790
0 ImagesReferencia número: HY-116881No. CAS: 221660-80-6SCH 57790 is a selective antegonist for muscarinic M2 receptor, which increases acetylcholine release, and thus improves cognitive performance. SCH 57790 reverses Scopolamine (HY-N0296)-induced memory deficits in mice, without significant toxicity (100 mg/kg).
-
VU0152100 (Standard)
0 ImagesSynonyms: VU152100 (Standard)VU0152100 (Standard) is the analytical standard of VU0152100. This product is intended for research and analytical applications. VU0152100 (VU152100) is a highly selective mAChR positive allosteric modulator (permeable to the blood-brain barrier). VU0152100 reverses Amphetamine-induced hypermotility in rats and increased levels of extracellular dopamine in nucleus accumbens and caudate-putamen. VU0152100 has good research potential in psychosis and cognitive impairment associated with mental disorders such as schizophrenia.
-
Dronedarone (Standard)
0 ImagesSynonyms: SR 33589 (Standard)Dronedarone (Standard) is the analytical standard of Dronedarone. This product is intended for research and analytical applications. Dronedarone (SR 33589), a derivative of amiodarone (HY-14187), is a class III antiarrhythmic agent for the study of atrial fibrillation (AF) and atrial flutter. Dronedarone is a potent blocker of multiple ion currents, including potassium current, sodium current, and L-type calcium current, and exhibits antiadrenergic effects by noncompetitive binding to β-adrenergic receptors. Dronedarone is a substrate for and a moderate inhibitor of CYP3A4.
-
LY 2033298 (Standard)
0 ImagesLY 2033298 (Standard) is the analytical standard of LY 2033298 (HY-101841). This product is intended for research and analytical applications. LY 2033298 is a selective positive allosteric modulator of the muscarinic M4 receptor. LY 2033298 can be used in the study of psychiatric disorders.
-
Cevimeline hydrochloride (Standard)
0 ImagesReferencia número: HY-70020BRNo. CAS: 107220-28-0Synonyms: AF102B hydrochloride (Standard)Cevimeline (hydrochloride) (Standard) is the analytical standard of Cevimeline (hydrochloride). This product is intended for research and analytical applications. Cevimeline hydrochloride (AF102B hydrochloride) is a quinuclidine derivative of acetylcholine and a selective and orally active muscarinic M1 and M3 receptor agonist. Cevimeline hydrochloride stimulates secretion by the salivary glands and can be used as a sialogogue for xerostomia. Cevimeline hydrochloride can cross the blood-brain barrier (BBB).
-
Biperiden-d5
0 ImagesReferencia número: HY-13204ASNo. CAS: 2938691-75-7Synonyms: KL 373-d5Biperiden-d5 (KL 373-d5) is deuterium labeled Biperiden. Biperiden (KL 373) is a non-selective muscarinic receptor antagonist that competitively binds to M1 muscarinic receptors, thereby inhibiting acetylcholine and enhancing dopamine signaling in the central nervous system. Biperiden has the potential for the research of Parkinson's disease and other related psychiatric disorders.
-
Aclidinium Bromide (Standard)
0 ImagesSynonyms: LAS 34273 (Standard); LAS-W 330 (Standard)Aclidinium (Bromide) (Standard) is the analytical standard of Aclidinium (Bromide). This product is intended for research and analytical applications. Aclidinium Bromide (LAS 34273; LAS-W 330) is a long-acting, inhaled muscarinic antagonist. Aclidinium Bromide has the potential for chronic obstructive pulmonary disease (COPD) research.
