mAChR
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mAChR Related Products (484)
Related Products (484)
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Desiodomethyl 4-DAMP
0 ImagesCat. No.: HY-134081CAS No.: 97762-23-7Desiodomethyl 4-DAMP is a muscarinic receptor antagonist.
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Batefenterol (Standard)
0 ImagesCat. No.: HY-12980RCAS No.: 743461-65-6Synonyms: GSK961081 (Standard); TD-5959 (Standard)Batefenterol (Standard) is the analytical standard of Batefenterol. This product is intended for research and analytical applications. Batefenterol (GSK961081;TD-5959) is a novel muscarinic receptor antagonist and β2-adrenoceptor agonist; displays high affinity for hM2, hM3 muscarinic and hβ2-adrenoceptor with Ki values of 1.4, 1.3 and 3.7 nM, respectively.
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3-Hydroxy darifenacin
0 ImagesCat. No.: HY-149504CAS No.: 206048-82-03-Hydroxy darifenacin is a metabolite of Darifenacin (HY-A0033). 3-Hydroxy darifenacin is an antagonist of M1-5 muscarinic receptors with Kis values of 17.78, 79.43, 2.24, 36.31 and 6.17 nM, respectively in CHO cells.
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Ethopropazine
0 ImagesCat. No.: HY-107922ACAS No.: 522-00-9Synonyms: Isothazine free base
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Desfesoterodine (Standard)
0 ImagesSynonyms: PNU-200577 (Standard); 5-Hydroxymethyl Tolterodine (Standard)Desfesoterodine (Standard) is the analytical standard of Desfesoterodine. This product is intended for research and analytical applications. Desfesoterodine (PNU-200577) is a potent and selective muscarinic receptor (mAChR) antagonist with a KB and a pA2 of 0.84 nM and 9.14, respectively. Desfesoterodine is a major pharmacologically active metabolite of Tolterodine (PNU-200583; HY-A0024) and Fesoterodine (HY-70053). Desfesoterodine improves cerebral infarction induced detrusor overactivity in rats.
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6-Hydroxytropinone
0 Images6-Hydroxytropinone is a cyclic hydroxylation product of Tropinone (HY-Y0135), and serves as an indicator for tropane alkaloid metabolism in plants or microorganisms. 6-Hydroxytropinone itself has no significant anticholinergic toxicity, nor does it act as a substrate for Tropine (HY-N7061) dehydrogenase.
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DREADD agonist 21 dihydrochloride (Standard)
0 ImagesCat. No.: HY-100234ARCAS No.: 2250025-92-2DREADD agonist 21 (dihydrochloride) (Standard) is the analytical standard of DREADD agonist 21 (dihydrochloride) (HY-100234A). This product is intended for research and analytical applications. DREADD agonist 21 dihydrochloride is a potent human muscarinic acetylcholine M3 receptors (hM3Dq) agonist (EC50=1.7 nM).
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Revefenacin-d3
0 ImagesCat. No.: HY-15851S2Synonyms: TD-4208-d3; GSK1160724-d3Revefenacin-d3 (TD-4208-d3) is deuterium labeled Revefenacin. Revefenacin (TD-4208; GSK1160724) is a potent mAChR antagonist; has a high affinity on M3 receptor with a Ki of 0.18 nM.
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Isopropamide iodide (Standard)
0 ImagesIsopropamide (iodide) (Standard) is the analytical standard of Isopropamide (iodide). This product is intended for research and analytical applications. Isopropamide iodide is a long-acting quaternary anticholinergic agent. Isopropamide iodide is used in peptic ulcer and other gastrointestinal disorders marked by hyperacidity and hypermotility.
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Octamylamine sulfamate
0 ImagesCat. No.: HY-W201842ACAS No.: 96296-56-9Octamylamine sulfamate is an anticholinergic and antispasmodic agent.
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Xanomeline tartrate (Standard)
0 ImagesSynonyms: LY 246708 tartrate (Standard)Xanomeline (tartrate) (Standard) is the analytical standard of Xanomeline (tartrate). This product is intended for research and analytical applications. Xanomeline (LY 246708) is the potent agonist of muscarinic M1/M4 receptor with antipsychotic-like activity. Xanomeline (LY 246708) increases neuronal excitability. Xanomeline (LY 246708) can be used for the research of schizophrenia.
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Cyclopentolate hydrochloride (Standard)
0 ImagesCat. No.: HY-B1621ARCAS No.: 5870-29-1Synonyms: DL-Cyclopentolate hydrochloride (Standard)Cyclopentolate (hydrochloride) (Standard) is the analytical standard of Cyclopentolate (hydrochloride). This product is intended for research and analytical applications. Cyclopentolate (DL-Cyclopentolate) hydrochloride is an Atropine-like muscarinic receptors antagonist with a pKB value of 7.8 (on the circular ciliary muscle). Cyclopentolate hydrochloride is an anti-muscarinic agent commonly used in the ophthalmologic practice.
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(S)-Albuterol
0 ImagesCat. No.: HY-137311ACAS No.: 34271-50-6(S)-Albuterol is a muscarinic receptor and phospholipase C activator. (S)-Albuterol increases intracellular free calcium in airway smooth muscle.
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Racanisodamine (Standard)
0 ImagesCat. No.: HY-N2064RCAS No.: 17659-49-3Racanisodamine Standard is the analytical standard of Racanisodamine (HY-N2064). This product is intended for research and analytical applications. Racanisodamine is an orally active, non-selective Muscarinic Acetylcholine Receptor (mAChR) antagonist. Racanisodamine is a racemate of Anisodamine, and the two share similar pharmacological effects. Racanisodamine is an active ingredient of eye drops for myopia control. Racanisodamine can be used in research on myopia and late dumping syndrome.
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GSK1034702 (Standard)
0 ImagesCat. No.: HY-107111RCAS No.: 932373-87-0GSK1034702 (Standard) is the analytical standard of GSK1034702 (HY-107111). This product is intended for research and analytical applications. GSK1034702 is an orally active and allosteric agonist of M1 mAChR (pEC50=8.1) that can cross the blood-brain barrier. GSK1034702 activates the Gq/11 protein-mediated signaling pathway, enhancing neuronal firing and long-term potentiation (LTP) in the CA1 region of the hippocampus. GSK1034702 can modulate hippocampal function, improve memory encoding in the nicotine withdrawal cognitive dysfunction model, and show pro-cognitive effects in rodents. GSK1034702 can be used for the study of the mechanisms of cognitive impairment diseases such as Alzheimer's disease, and has certain peripheral M receptor activation-related side effects (such as gastrointestinal reactions).
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Ipratropium bromide hydrate (Standard)
0 ImagesSynonyms: Sch 1000 bromide hydrate (Standard)Ipratropium (bromide hydrate) (Standard) is the analytical standard of Ipratropium (bromide hydrate). This product is intended for research and analytical applications. Ipratropium bromide (Sch 1000) hydrate is a muscarinic receptor antagonist, with IC50s of 2.9 nM, 2 nM, and 1.7 nM for M1, M2, and M3 receptors, respectively. Ipratropium bromide hydrate relaxes smooth muscle, can be used in the research for COPD (chronic obstructive pulmonary disease) and asthma.
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Thiothixene
0 ImagesThiothixene is a typical antipsychotic. It selectively binds to dopamine D2 over D1, D3, and D4 receptors (Kis=0.417, 338, 186.2, and 363.1 nM, respectively). Thiothixene also binds to various serotonin (5-HT), histamine H1, α1- and α2-adrenergic, muscarinic acetylcholine, and sigma receptors (Kis=15-5,754 nM) as well as the dopamine, norepinephrine, and serotonin transporters (Kis=3.16-30 μM). In vivo, thiothixene reduces spontaneous and amphetamine-induced locomotor activity in rats. It enhances latent inhibition, as measured by a decreased lick latency in response to light and foot shock stimuli, which is a measure of selective attention in rats.3 Thiothixene also increases competitive behavior in submissive mice, indicating antidepressant-like behavior.
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Blarcamesine (Standard)
0 ImagesBlarcamesine (Standard) is the analytical standard of Blarcamesine (HY-105296). This product is intended for research and analytical applications. Blarcamesine is an orally bioavailable Sigma-1 receptor agonist and muscarinic receptor modulator, with anticonvulsant, anti-amnesic, neuroprotective and antidepressant properties. Blarcamesine ameliorates neurologic impairments in a mouse model of Rett syndrome.
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BQCA (Standard)
0 ImagesCat. No.: HY-101858RCAS No.: 338747-41-4
