mAChR
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mAChR Related Products (484)
Related Products (484)
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Methacholine chloride (Standard)
0 ImagesMethacholine (chloride) (Standard) is the analytical standard of Methacholine (chloride). This product is intended for research and analytical applications. Methacholine (Acetyl-β-methylcholine) choride is a potent muscarinic-3 (M3) agonist. Methacholine choride acts directly on acetylcholine receptors on smooth muscle causing bronchoconstriction and airway narrowing. Methacholine choride shows a high sensitivity to identify bronchial hyperresponsiveness (BHR). Methacholine choride can be used to measure airway hyperresponsiveness (AHR) as a diagnostic aid in the assessment of individuals with asthma-like symptoms and normal resting expiratory flow rates.
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Pilocarpine nitrate (Standard)
0 ImagesPilocarpine (nitrate) (Standard) is the analytical standard of Pilocarpine (nitrate). This product is intended for research and analytical applications. Pilocarpine nitrate is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.
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Secoverine
0 ImagesCat. No.: HY-183540CAS No.: 57558-44-8Secoverine is a muscarinic cholinergic receptor (mAChR) antagonist and antispasmodic with blood-brain barrier permeability. Secoverine binds competitively to muscarinic receptors, blocks central cholinergic effects, and inhibits cholinergically induced gastrointestinal motility, intestinal smooth muscle contraction, and acetylcholine-mediated neurotransmitter release. Secoverine exerts direct antispasmodic activity on intestinal smooth muscle independent of receptor blockade, and exhibits characteristics such as reversible smooth muscle activity and long duration of action. Secoverine can be used in studies related to hyperintestinal motility, diverticular disease, and colonic spasm.
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Olanzapine-d4
0 ImagesCat. No.: HY-14541S1CAS No.: 1252611-62-3Synonyms: LY170053-d4
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RHC 80267 (Standard)
0 ImagesCat. No.: HY-107416RCAS No.: 83654-05-1Synonyms: U-57908 (Standard)RHC 80267 (Standard) is the analytical standard of RHC 80267 (HY-107416). This product is intended for research and analytical applications. RHC 80267 (U-57908) is a potent and selective inhibitor of diacylglycerol lipase (DAGL) (with IC50 of 4 μM in canine platelets). RHC-80267 inhibits cholinesterase activity with an IC50 of 4 μM, thereby enhancing the relaxation evoked by acetylcholine. RHC 80267 also inhibits COX and the hydrolysis of phosphatidylcholine (PC).
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Cevimeline hydrochloride hemihydrate (Standard)
0 ImagesCat. No.: HY-76772RCAS No.: 153504-70-2Synonyms: SNI-2011 (Standard); AF102B hydrochloride hemihydrate (Standard)Cevimeline (hydrochloride hemihydrate) (Standard) is the analytical standard of Cevimeline (hydrochloride hemihydrate). This product is intended for research and analytical applications. Cevimeline hydrochloride hemihydrate (SNI-2011) is a quinuclidine derivative of acetylcholine and a selective and orally active muscarinic M1 and M3 receptor agonist. Cevimeline hydrochloride hemihydrate stimulates secretion by the salivary glands and can be used as a sialogogue for xerostomia. Cevimeline hydrochloride hemihydrate can cross the blood-brain barrier (BBB).
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CDD0102 hydrochloride
0 ImagesCat. No.: HY-U00230ACAS No.: 1196130-86-5CDD0102 Hydrochloride is a potent M1 Muscarinic receptor agonist.
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Piperidolate (Standard)
0 ImagesCat. No.: HY-B0962ARCAS No.: 82-98-4Piperidolate (Standard) is the analytical standard of Piperidolate. This product is intended for research and analytical applications. Piperidolate is a cholinergic antagonist. Piperidolate prevents ventricular fibrillation during hypothermic cardiac manipulations to support cardiac procedures post-preoperative defibrillation. Piperidolate causes dose-dependent cardiac depression. Piperidolate can be used for the research of ventricular fibrillation.
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(±)-Darifenacin N-Oxide
0 ImagesCat. No.: HY-W746075ACAS No.: 2416229-88-2(±)-Darifenacin N-Oxide is the impurity of Darifenacin (HY-A0033). Darifenacin (UK-88525) is a selective and orally active M3 muscarinic receptor (M3R) antagonist with a pKi of 8.9.
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Tolterodine (Standard)
0 ImagesCat. No.: HY-A0024RCAS No.: 124937-51-5Synonyms: (R)-(+)-Tolterodine (Standard); (+)-Tolterodine (Standard); (R)-Tolterodine (Standard); PNU-200583 (Standard)Tolterodine (Standard) is the analytical standard of Tolterodine. This product is intended for research and analytical applications. Tolterodine ((R)-(+)-Tolterodine) is a mAChR inhibitor and substrate for cytochrome P450 enzymes. Tolterodine competitively binds acetylcholine, reduces sympathetic excitation, and inhibits involuntary bladder muscle contraction. Tolterodine restores the Nrf2/NF-κB signaling pathway, mediates protection against inflammatory response and ferroptosis. Tolterodine ameliorates LPS (HY-D1056)-induced reactive oxygen species production and lipid oxidation. Tolterodine can be used for the research of urinary tract infections and overactive bladder.
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Dimethyl-W84 dibromide
0 ImagesCat. No.: HY-122491CAS No.: 402475-33-6Dimethyl-W84 (dibromide) modulates M2 muscarinic acetylcholine receptors. Dimethyl-W84 (dibromide) can be used in nervous system related research.
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Baogongteng A
0 ImagesCat. No.: HY-125700CAS No.: 74239-84-2Synonyms: (-)-Bao Gong Teng ABaogongteng A ((-)-Bao Gong Teng A) is an optically active tropane alkaloid with hypotensive and miotic activity, and can be isolated from the Chinese herb Erycibe obtusifolia Benth. Baogongteng A is also a muscarinic agonist. Baogongteng A can be used for cardiovascular and glaucoma research.
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Anisodine hydrobromide
0 ImagesCat. No.: HY-127022ACAS No.: 76822-34-9Synonyms: Daturamine hydrobromide; α-Hydroxyscopolamine hydrobromideAnisodine (Daturamine) hydrobromide is a neuroprotective compound that reduces exacerbated M1, M2, M4, and M5 receptor expression in brain tissues under hypoxia/reoxygenation conditions. Anisodine hydrobromide inhibits calcium ion influx and reactive oxygen species (ROS)levels. Anisodine hydrobromide leads to decreased aspartate levels during hypoxia.
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Tolterodine dimer
0 ImagesCat. No.: HY-W708197CAS No.: 854306-72-2Tolterodine dimer is the impurity of Tolterodine (HY-A0024). Tolterodine is a potent muscarinic receptor antagonist.
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Oxyphencyclimine hydrochloride (Standard)
0 ImagesOxyphencyclimine (hydrochloride) (Standard) is the analytical standard of Oxyphencyclimine (hydrochloride). This product is intended for research and analytical applications. A new tertiary amine, Oxyphencyclimine hydrochloride，has been investigated for its effects on the peripheral parasympathetic system.
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Acetylcholine iodide (Standard)
0 ImagesSynonyms: ACh iodide (Standard)Acetylcholine (iodide) (Standard) is the analytical standard of Acetylcholine (iodide). This product is intended for research and analytical applications. Acetylcholine iodide (ACh iodide) is a common neurotransmitter found in the central and peripheral nerve system.
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NNC 11-1607
0 ImagesCat. No.: HY-119333CAS No.: 250649-13-9NNC 11-1607 is a selective M1/M4 muscarinic acetylcholine receptor (mAChR) agonist. NNC 11-1607 inhibits Forskolin (HY-15371)-stimulated cAMP accumulation in Chinese hamster ovary cells expressing the human M2 or M4 mAChR. NNC 11-1607 is promising for research of central nervous system disorders, such as Alzheimer’s disease and schizophrenia.
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AC260584 (Standard)
0 ImagesCat. No.: HY-100336RCAS No.: 560083-42-3
