mAChR
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mAChR Related Products (484)
Related Products (484)
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Diphenidol-d10 hydrochloride
0 ImagesCat. No.: HY-A0082SSynonyms: Difenidol hydrochloride-d10Diphenidol-d10 (hydrochloride) (Difenidol hydrochloride-d10) is deuterium labeled Diphenidol (hydrochloride). Diphenidol hydrochloride (Difenidol hydrochloride) is a non-selective muscarinic M1-M4 receptor antagonist, has anti-arrhythmic activity. Diphenidol hydrochloride is also a potent non-specific blocker of voltage-gated ion channels (Na+, K+, and Ca2+) in neuronal cells. Diphenidol hydrochloride can be used in the study of antivertigo and antinausea.
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Biperiden (Standard)
0 ImagesCat. No.: HY-13204ARCAS No.: 514-65-8Synonyms: KL 373 (Standard)Biperiden (Standard) is the analytical standard of Biperiden. This product is intended for research and analytical applications. Biperiden (KL 373) is a non-selective muscarinic receptor antagonist that competitively binds to M1 muscarinic receptors, thereby inhibiting acetylcholine and enhancing dopamine signaling in the central nervous system. Biperiden has the potential for the research of Parkinson's disease and other related psychiatric disorders.
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Solifenacin N-oxide
0 ImagesCat. No.: HY-43421CAS No.: 180272-28-0Synonyms: Solifenacin N1-oxideSolifenacin N-oxide (Solifenacin N1-oxide) is an inactive metabolite of the muscarinic receptor antagonist Solifenacin (HY-A0034).
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Smilagenin (Standard)
0 ImagesCat. No.: HY-106353RCAS No.: 126-18-1Smilagenin (Standard) is the analytical standard of Smilagenin. This product is intended for research and analytical applications. Smilagenin (SMI) is a small-molecule steroidal sapogenin from Anemarrhena asphodeloides and Pelargonium hortorum widely used in traditional Chinese medicine for treating chronic neurodegeneration diseases. Smilagenin (SMI) improves memory of aged rats by increasing the muscarinic receptor subtype 1 (M1)-receptor density. Smilagenin (SMI) attenuates Aβ(25-35)-induced neurodegenerationvia stimulating the gene expression of brain-derived neurotrophic factor, may represents a novel therapeutic strategy for AD.
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Pirmenol hydrochloride (Standard)
0 ImagesCat. No.: HY-100795ARCAS No.: 61477-94-9Synonyms: (±)-Pirmenol hydrochloride (Standard); CI-845 (Standard)Pirmenol (hydrochloride) (Standard) is the analytical standard of Pirmenol (hydrochloride) (HY-100795A). This product is intended for research and analytical applications. Pirmenol ((±)-Pirmenol) hydrochloride is an orally active antiarrhythmic agent. Pirmenol hydrochloride inhibits IK.ACh (IC50: 0.1 μM) by blocking mAchR. Pirmenol hydrochloride can be used in the research of cardiovascular disease, such as atrial fibrillation.
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Flavoxate-d4 (hydrochloride)
0 ImagesCat. No.: HY-B0549ASCAS No.: 1189678-43-0Flavoxate-d4 hydrochloride (Rec-7-0040-d4) is the deuterium labeled Flavoxate hydrochloride. Flavoxate hydrochloride (Rec-7-0040; DW61) is an orally active L-type Ca2+ channel inhibitor and antispasmodic. Flavoxate hydrochloride inhibits cyclic adenosine monophosphate production by blocking voltage-dependent inward Ba2+ currents, regulating the brainstem micturition center, and stimulating G protein-coupled receptors. Consequently, Flavoxate hydrochloride induces relaxation of bladder smooth muscle and inhibits isovolumetric rhythmic contractions. Flavoxate hydrochloride effectively increases bladder capacity and alleviates symptoms of urgent urination frequency and pollakiuria caused by overactive bladder. Flavoxate hydrochloride can be used in research on overactive bladder and related voiding dysfunctions.
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Camylofin dihydrochloride
0 ImagesCamylofine dihydrochloride is an antispasmodic agent with myogenic and neurogenic effects. Camylofine dihydrochloride exhibits mild anticholinergic activity and blocks the M3 receptors on colonic smooth muscle. Camylofine dihydrochloride inhibits phosphodiesterase, elevates intracellular cAMP levels and reduces intracellular Ca2+ levels, thereby promoting smooth muscle relaxation. Camylofine dihydrochloride can be used in studies related to antispasmodia, gastrointestinal smooth muscle and ulcerative colitis.
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Pilocarpine Hydrochloride (Standard)
0 ImagesPilocarpine (Hydrochloride) (Standard) is the analytical standard of Pilocarpine (Hydrochloride). This product is intended for research and analytical applications. Pilocarpine Hydrochloride is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.
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N-Desethyloxybutynin hydrochloride
0 ImagesCat. No.: HY-W739521CAS No.: 81039-77-2N-Desethyloxybutynin hydrochloride is an active metabolite of Oxybutynin. N-Desethyloxybutynin hydrochloride binds to mAChRs in isolated? human bladder and human parotid gland with pKi values of 8.2 and 8.7, respectively.
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Phenglutarimid hydrochloride
0 ImagesCat. No.: HY-U00001ACAS No.: 1674-96-0Synonyms: Ciba 10870 hydrochloride; Phenglutarimide hydrochloridePhenglutarimid hydrochloride is an anticholinergic used as an antiparkinsonian agent.
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YM-58790 (Standard)
0 ImagesCat. No.: HY-101679RCAS No.: 214558-72-2YM-58790 (Standard) is the analytical standard of YM-58790 (HY-101679). This product is intended for research and analytical applications. YM-58790 is a potent antagonist of mAChR. YM-58790 binds M1, M2, M3 with Ki values of 28 nM, 260 nM, and 15 nM. YM-58790 exhibits potent inhibitory activity on bladder pressuer in reflexly-evoked rhythmic contraction in rats.
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(R)-Hydroxytolterodine-d14
0 ImagesCat. No.: HY-76569S1CAS No.: 1191280-58-6Synonyms: PNU-200577-d14; 5-Hydroxymethyl Tolterodine-d14(R)-Hydroxytolterodine-d14 is deuterated labeled Desfesoterodine (HY-76569). Desfesoterodine (PNU-200577) is a potent and selective muscarinic receptor (mAChR) antagonist with a KB and a pA2 of 0.84 nM and 9.14, respectively. Desfesoterodine is a major pharmacologically active metabolite of Tolterodine (PNU-200583; HY-A0024) and Fesoterodine (HY-70053). Desfesoterodine improves cerebral infarction induced detrusor overactivity in rats.
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WIN 62,577
0 ImagesCat. No.: HY-118356CAS No.: 144177-32-2WIN 62,577 is a rat-specific, but non-human, NK1 receptor antagonist. WIN 62,577 interacts with M1-M4 mAChRs and is an allosteric enhancer of acetylcholine affinity targeting the M3 receptor.
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Dicyclomine hydrochloride (Standard)
0 ImagesDicyclomine (hydrochloride) (Standard) is the analytical standard of Dicyclomine (hydrochloride). This product is intended for research and analytical applications. Dicyclomine hydrochloride is a potent and orally active muscarinic cholinergic receptors antagonist. Dicyclomine hydrochloride shows high affinity for muscarinic M1 receptor subtype (Ki=5.1 nM) and M2 receptor subtype (Ki=54.6 nM) in brush-border membrane and basal plasma membranes, respectively. Dicyclomine is an antispasmodic agent and relieves smooth muscle spasm of the gastrointestinal tract in vivo.
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Irsogladine (Standard)
0 ImagesSynonyms: Dicloguamine (Standard)Irsogladine (Standard) is the analytical standard of Irsogladine. This product is intended for research and analytical applications. 0
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Cyclodrine hydrochloride
0 ImagesCat. No.: HY-U00139CAS No.: 78853-39-1
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CDD0102
0 ImagesCat. No.: HY-U00230CAS No.: 146422-58-4Synonyms: CDD0102ACDD0102 is a potent M1 Muscarinic receptor agonist.
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Tematropium
0 ImagesSynonyms: CDDD3602; HGP6Tematropium (CDDD3602) is a soft anticholinergics.
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BTM-1086
0 ImagesCat. No.: HY-U00406CAS No.: 72293-17-5BTM-1086 is a potent anti-ulcer and gastric secretory inhibiting agent.
