2. Signaling Pathways
  3. Vitamin D Related/Nuclear Receptor
  4. Orphan Nuclear Receptor
  5. Orphan Nuclear Receptor Agonist

Orphan Nuclear Receptor Agonist

Orphan Nuclear Receptor Agonists (12):

Cat. No. Product Name Effect Purity
  • HY-B1058
    Benfluorex hydrochloride
    		Agonist 99.85%
    Benfluorex hydrochloride (JP-992 hydrochloride) is a hepatic nuclear factor 4 alpha (HNF4α) activator.
  • HY-134462A
    RJW103 TFA
    		Agonist
    RJW103 TFA is an acid-stable SF-1 (NR5A1) and LRH-1 agonist with pEC50 values of 6.5 and 5.9, respectively. RJW103 TFA activates SF-1- and LRH-1-mediated transcription of endogenous target genes. RJW103 TFA can be used in research on cancer, endocrinology and metabolic diseases, such as adrenocortical tumors.
  • HY-180403
    TLX agonist 3
    		Agonist
    TLX agonist 3 is a potent and selective tailless homolog (TLX, NR2E1) agonist with an EC50 of 0.25 μM and a Kd of 1.6 μM). TLX agonist 3 shows high selectivity over related nuclear receptors, and promotes TLX oligomerization with an EC50 of 5.0 μM. TLX agonist 3 can be used for the research of neurodegenerative diseases.
  • HY-176136
    HNF4 agonist 1
    		Agonist 99.37%
    HNF4 agonist 1 is a HNF4 agonist. HNF4 agonist 1 activates HNF4α and HNF4γ with EC50 values of 6 nM and 17 nM, respectively. HNF4 agonist 1 can be used in studies related to maturity-onset diabetes of the young type 1 (mody-1).
  • HY-147105
    LRH-1 agonist-2
    		Agonist 98.58%
    LRH-1 agonist-2 (Compound 6N) is a selective, full LRH-1 agonist with an EC50 of 15.7 nM. LRH-1 agonist-2 directly interacts with the Thr352 and His390 residues in the LRH-1 binding pocket, promotes allosteric signaling to the activation function surface (AFS), stabilizes the AFS and enhances coactivator recruitment. LRH-1 agonist-2 induces the anti-inflammatory cytokine IL-10, and reduces the pro-inflammatory cytokines IL-1β and TNFα. LRH-1 modulator-1 exerts anti-inflammatory effects in intestinal organoids. LRH-1 modulator-1 can be used in studies related to inflammatory bowel disease.
  • HY-134462
    RJW103
    		Agonist 98.71%
    RJW103 is an acid-stable SF-1 (NR5A1) and LRH-1 agonist with pEC50 values of 6.5 and 5.9, respectively. RJW103 activates SF-1- and LRH-1-mediated transcription of endogenous target genes. RJW103 can be used in research on cancer, endocrinology and metabolic diseases, such as adrenocortical tumors.
  • HY-161115
    NR2E3 agonist 1
    		Agonist 99.48%
    NR2E3 agonist 1 (Compound 11a) is a small molecule agonist of the photoreceptor-specific nuclear receptor (NR2E3) with an EC50 value of less than 200 nM. NR2E3 agonist 1 can be used in retinitis pigmentosa research.
  • HY-148608
    LysoPalloT-NH-amide-C3-ph-m-O-C11
    		Agonist
    LysoPalloT-NH-amide-C3-ph-m-O-C11 is an agonist for GPR174 with an EC50 of 34 nM.
  • HY-164814
    GPR27 agonist-1
    		Agonist
    GPR27 Agonist-1 (compound I) is a selective GPR27 agonist with pEC50 of 6.34.
  • HY-168051
    TLX agonist 2
    		Agonist
    TLX agonist 2 (compound 31) is a TLX agonist (EC50=0.1 μM; Kd=0.16 μM). TLX agonist 2 promotes TLX transcriptional activity and enhances the expression of TLX target genes by binding to TLX. TLX agonist 2 can be used in the study of neurodegenerative diseases.
  • HY-B1058A
    Benfluorex
    		Agonist
    Benfluorex (JP-992) is a hepatic nuclear factor 4 alpha (HNF4α) activator.
  • HY-B1058R
    Benfluorex hydrochloride (Standard)
    		Agonist
    Benfluorex (hydrochloride) (Standard) is the analytical standard of Benfluorex (hydrochloride). This product is intended for research and analytical applications. Benfluorex hydrochloride (JP-992 hydrochloride) is a hepatic nuclear factor 4 alpha (HNF4α) activator.