Orphan Nuclear Receptor Agonist

Benfluorex hydrochloride (JP-992 hydrochloride) is a hepatic nuclear factor 4 alpha (HNF4α) activator.

RJW103 TFA is an acid-stable SF-1 (NR5A1) and LRH-1 agonist with pEC₅₀ values of 6.5 and 5.9, respectively. RJW103 TFA activates SF-1- and LRH-1-mediated transcription of endogenous target genes. RJW103 TFA can be used in research on cancer, endocrinology and metabolic diseases, such as adrenocortical tumors.

TLX agonist 3 is a potent and selective tailless homolog (TLX, NR2E1) agonist with an EC₅₀ of 0.25 μM and a K_d of 1.6 μM). TLX agonist 3 shows high selectivity over related nuclear receptors, and promotes TLX oligomerization with an EC₅₀ of 5.0 μM. TLX agonist 3 can be used for the research of neurodegenerative diseases.

HNF4 agonist 1 is a HNF4 agonist. HNF4 agonist 1 activates HNF4α and HNF4γ with EC₅₀ values of 6 nM and 17 nM, respectively. HNF4 agonist 1 can be used in studies related to maturity-onset diabetes of the young type 1 (mody-1).

LRH-1 agonist-2 (Compound 6N) is a selective, full LRH-1 agonist with an EC₅₀ of 15.7 nM. LRH-1 agonist-2 directly interacts with the Thr352 and His390 residues in the LRH-1 binding pocket, promotes allosteric signaling to the activation function surface (AFS), stabilizes the AFS and enhances coactivator recruitment. LRH-1 agonist-2 induces the anti-inflammatory cytokine IL-10, and reduces the pro-inflammatory cytokines IL-1β and TNFα. LRH-1 modulator-1 exerts anti-inflammatory effects in intestinal organoids. LRH-1 modulator-1 can be used in studies related to inflammatory bowel disease.

RJW103 is an acid-stable SF-1 (NR5A1) and LRH-1 agonist with pEC₅₀ values of 6.5 and 5.9, respectively. RJW103 activates SF-1- and LRH-1-mediated transcription of endogenous target genes. RJW103 can be used in research on cancer, endocrinology and metabolic diseases, such as adrenocortical tumors.

NR2E3 agonist 1 (Compound 11a) is a small molecule agonist of the photoreceptor-specific nuclear receptor (NR2E3) with an EC₅₀ value of less than 200 nM. NR2E3 agonist 1 can be used in retinitis pigmentosa research.

LysoPalloT-NH-amide-C3-ph-m-O-C11 is an agonist for GPR174 with an EC₅₀ of 34 nM.

GPR27 Agonist-1 (compound I) is a selective GPR27 agonist with pEC₅₀ of 6.34.

TLX agonist 2 (compound 31) is a TLX agonist (EC₅₀=0.1 μM; K_d=0.16 μM). TLX agonist 2 promotes TLX transcriptional activity and enhances the expression of TLX target genes by binding to TLX. TLX agonist 2 can be used in the study of neurodegenerative diseases.

Benfluorex (JP-992) is a hepatic nuclear factor 4 alpha (HNF4α) activator.

Benfluorex (hydrochloride) (Standard) is the analytical standard of Benfluorex (hydrochloride). This product is intended for research and analytical applications. Benfluorex hydrochloride (JP-992 hydrochloride) is a hepatic nuclear factor 4 alpha (HNF4α) activator.