2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. PANK
  5. PANK Inhibitor

PANK Inhibitor

PANK Isoform Comparison

PANK Inhibitors (2):

Cat. No. Product Name Effect Purity
  • HY-44170
    Pantothenate kinase-IN-2
    		Inhibitor 98.18%
    Pantothenate kinase-IN-2 is a pantothenate kinase inhibitor with IC50 values of 92 nM for PanK2, 70 nM for PanK1β, and 25 nM for PanK3. Pantothenate kinase-IN-2 can bind specifically to the ATP-PanK3 complex and block CoA biosynthesis. Pantothenate kinase-IN-2 can be used for the research of pank-associated neurodegeneration and type 2 diabetes.
  • HY-144734
    Pantothenate kinase-IN-1
    		Inhibitor 98.20%
    Pantothenate kinase-IN-1 is a PANK3 inhibitor with an IC50 of 0.51 μM. Pantothenate kinase-IN-1 acts as a pantothenate-competitive inhibitor, which occupies the pantothenate-binding site of PANK3 and binds to both protomers in the PANK3 dimer. Pantothenate kinase-IN-1 exhibits metabolic stability in mouse and rat plasma. Pantothenate kinase-IN-1 can be used in the research of pantothenate kinase-associated neurodegenerative diseases and metabolic diseases.