1. Metabolic Enzyme/Protease
  2. E1/E2/E3 Enzyme
  3. UbcH5c-IN-1

UbcH5c-IN-1 

Cat. No.: HY-103046
Handling Instructions

UbcH5c-IN-1 (compound 6d) is a potent and selective small-molecule inhibitor of Ubiquitin-conjugating enzyme UbcH5c, with a Kd of 283 nM for E2 UbcH5c-IN-1 by covalent binding with Cys85. A promising lead compound for the development of new antirheumatoid arthritis (RA) agent.

For research use only. We do not sell to patients.

UbcH5c-IN-1 Chemical Structure

UbcH5c-IN-1 Chemical Structure

CAS No. : 2123480-72-6

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Description

UbcH5c-IN-1 (compound 6d) is a potent and selective small-molecule inhibitor of Ubiquitin-conjugating enzyme UbcH5c, with a Kd of 283 nM for E2 UbcH5c-IN-1 by covalent binding with Cys85. A promising lead compound for the development of new antirheumatoid arthritis (RA) agent[1].

IC50 & Target

Kd: 283 nM (E2 UbcH5c)[1].

In Vivo

UbcH5c-IN-1 (compound 6d) (5 and 20 mg/kg, p.o., daily, 10-20 days) treatment in Freund’s adjuvant (CFA)-induced adjuvant arthritis (AA) rat model results in appreciable decreases in the arthritis index score and hind paw swelling rate compared with those of the vehicle-treated AA model control group[1].

Animal Model: Freund’s adjuvant (CFA)-induced adjuvant arthritis (AA) rat model[1].
Dosage: 5 and 20 mg/kg
Administration: Oral administration daily between day 10-20 postimmunization.
Result: Resulted in appreciable decreases in the arthritis index score and hind paw swelling rate compared with those of the vehicle-treated AA model control group.
Molecular Weight

413.30

Formula

C₂₂H₂₁BrO₃

CAS No.

2123480-72-6

SMILES

BrC1=CC=CC=C1COC2=C(C)C([[email protected]](OC(C3=C)=O)[[email protected]]3CC4)=C4C(C)=C2

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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UbcH5c-IN-1
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