2. Metabolic Enzyme/Protease
  3. E1/E2/E3 Enzyme
  4. UbcH5c-IN-1

UbcH5c-IN-1 (compound 6d) is a potent and selective small-molecule inhibitor of Ubiquitin-conjugating enzyme UbcH5c, with a Kd of 283 nM for E2 UbcH5c-IN-1 by covalent binding with Cys85. A promising lead compound for the development of new antirheumatoid arthritis (RA) agent.

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UbcH5c-IN-1 Chemical Structure

UbcH5c-IN-1 Chemical Structure

CAS No. : 2123480-72-6

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UbcH5c-IN-1 Related Antibodies

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Description

UbcH5c-IN-1 (compound 6d) is a potent and selective small-molecule inhibitor of Ubiquitin-conjugating enzyme UbcH5c, with a Kd of 283 nM for E2 UbcH5c-IN-1 by covalent binding with Cys85. A promising lead compound for the development of new antirheumatoid arthritis (RA) agent[1].

IC50 & Target

Kd: 283 nM (E2 UbcH5c)[1].
In Vivo

UbcH5c-IN-1 (compound 6d) (5 and 20 mg/kg, p.o., daily, 10-20 days) treatment in Freund’s adjuvant (CFA)-induced adjuvant arthritis (AA) rat model results in appreciable decreases in the arthritis index score and hind paw swelling rate compared with those of the vehicle-treated AA model control group[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Freund’s adjuvant (CFA)-induced adjuvant arthritis (AA) rat model[1].
Dosage: 5 and 20 mg/kg
Administration: Oral administration daily between day 10-20 postimmunization.
Result: Resulted in appreciable decreases in the arthritis index score and hind paw swelling rate compared with those of the vehicle-treated AA model control group.
Molecular Weight

413.30

Formula

C22H21BrO3
CAS No.
SMILES

BrC1=CC=CC=C1COC2=C(C)C([C@H](OC(C3=C)=O)[C@H]3CC4)=C4C(C)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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UbcH5c-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UbcH5c-IN-12123480-72-6E1/E2/E3 EnzymeE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseInhibitorinhibitorinhibit

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