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Cat. No.: HY-183239

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A2AR/A2BR antagonist 2

A2AR/A2BR antagonist 2 is a dual A_2A/A_2B adenosine receptor antagonist with selectivity for the A₁ receptor. A2AR/A2BR antagonist 2 reverses adenosine-mediated T-cell immunosuppression in the tumor microenvironment. A2AR/A2BR antagonist 2 can be used in cancer-related research.

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CAS No.: 2975718-45-5
Formule: C₂₂H₂₆N₈O
Masse moléculaire:418.49

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Please store the product under the recommended conditions in the Certificate of Analysis.

A2AR/A2BR antagonist 2 Chemical Structure

CAS No.: 2975718-45-5

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Description

Voir tous les produits spécifiques à Isoform Adenosine Receptor :

In Vitro

A2AR/A2BR antagonist 2 (compound 34) potently inhibits recombinant A₂_AR (K_i = 0.3 nM, cAMP IC₅₀ = 4.2 nM) and recombinant A₂_BR (cAMP IC₅₀ = 21.1 nM), and exhibits high selectivity for recombinant A₁R (K_i = 541.0 nM) with a selectivity factor of approximately 1803-fold^[1].
A2AR/A2BR antagonist 2 exhibits off-target inhibitory activity against protein serine/threonine kinases (IC₅₀ = 1 μM), as well as off-target inhibitory activity against muscarinic M₁-M₄ receptors (IC₅₀ = 2-6 μM), serotonin 5-HT_1B receptor (IC₅₀ = 2 μM) and 5-HT_2B receptor (IC₅₀ = 5 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2975718-45-5
Masse moléculaire 418.49
Formule C₂₂H₂₆N₈O
SMILES

COC1=CC=CC2=C1N=C(N3N=C(N=C23)[C@H]4C[C@@H](C4)C5=C(N=C(C=N5)C(C)(N)C)C)N
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Brill ZG, et al. Discovery of Potent 1, 3-Cyclobutane-Containing Dual A2A/A2B Receptor Antagonists with Low Projected Human Dose for the Treatment of Cancer. ACS Medicinal Chemistry Letters. 2026 Apr 14.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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A2AR/A2BR antagonist 2

Voir tous les produits spécifiques à Isoform Adenosine Receptor

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

A2AR/A2BR antagonist 2 Related Classifications

HY-183239 Related Classifications