A2AR/A2BR antagonist 2
A2AR/A2BR antagonist 2 is a dual A2A/A2B adenosine receptor antagonist with selectivity for the A1 receptor. A2AR/A2BR antagonist 2 reverses adenosine-mediated T-cell immunosuppression in the tumor microenvironment. A2AR/A2BR antagonist 2 can be used in cancer-related research.
For research use only. We do not sell to patients.
- CAS No.: 2975718-45-5
- Formula: C22H26N8O
- Molecular Weight:418.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Adenosine Receptor Isoforms
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Biological Activity
A2AR/A2BR antagonist 2 (compound 34) potently inhibits recombinant A2AR (Ki = 0.3 nM, cAMP IC50 = 4.2 nM) and recombinant A2BR (cAMP IC50 = 21.1 nM), and exhibits high selectivity for recombinant A1R (Ki = 541.0 nM) with a selectivity factor of approximately 1803-fold[1].
A2AR/A2BR antagonist 2 exhibits off-target inhibitory activity against protein serine/threonine kinases (IC50 = 1 μM), as well as off-target inhibitory activity against muscarinic M1-M4 receptors (IC50 = 2-6 μM), serotonin 5-HT1B receptor (IC50 = 2 μM) and 5-HT2B receptor (IC50 = 5 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2975718-45-5
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Molecular Weight 418.49
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Formula C22H26N8O
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SMILES
COC1=CC=CC2=C1N=C(N3N=C(N=C23)[C@H]4C[C@@H](C4)C5=C(N=C(C=N5)C(C)(N)C)C)N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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