ABBV-712
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Based on 1 Customer Validation
ABBV-712 is a selective and orally active inhibitor of Tyrosine kinase 2 (TYK2). ABBV-712 has EC50 values of 0.01, 0.19, and 0.17 μM for TYK2 JH2, TYK2 cells and human whole blood, respectively. ABBV-712 has anti-inflammatory activity and can be used in the research of autoimmune diseases.
For research use only. We do not sell to patients.
- Purity: 99.94%
- CAS No.: 2368945-27-9
- Formula: C24H28N4O5
- Molecular Weight:452.50
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
Description
In Vivo
ABBV-712 (100 mg/kg; oral administration; BID/QD; 5 days) has a protective effect in the mouse ear dermatitis model and can reduce the ear thickness of mice[1].
ABBV-712 (10-600 mg/kg; oral administration; single dose) can inhibit the production of IFN-γ in a dose-dependent manner in mice stimulated with IL-12/IL-18[1].
Pharmacokinetic Analysis in Rats[1]
ABBV-712 (10-600 mg/kg; oral administration; single dose) can inhibit the production of IFN-γ in a dose-dependent manner in mice stimulated with IL-12/IL-18[1].
Pharmacokinetic Analysis in Rats[1]
| Route | Dose (mg/kg) | CLb,u (L/h/kg) | T1/2 (h) | VSS (L/kg) | F (%) |
| p.o. and i.v. | 1 | 4.1 | 0.6 | 1.9 | 19 |