ABD-350
ABD-350 is an antiresorptive agent that inhibits osteoclast activity without affecting osteoblast activity and preventing ovariectomy-induced bone loss. ABD-350 inhibits NF-κB ligand-induced inhibitor of NF-κB phosphorylation, leading to osteoclast apoptosis, but has no inhibitory effect on osteoblast function, effectively preventing bone loss in ovariectomized mice, and does not inhibit parathyroid hormone-induced bone formation.
For research use only. We do not sell to patients.
- CAS No.: 1117772-52-7
- Formula: C19H22F2O2
- Molecular Weight:320.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| J774 | IC50 |
8 μM
Compound: 3u
|
Cytotoxicity against mouse J774 cells expressing RANKL signaling by Alamar blue assay
Cytotoxicity against mouse J774 cells expressing RANKL signaling by Alamar blue assay
|
[PMID: 20692834] |
| Osteoblast | IC50 |
>100 μM
Compound: 3u
|
Cytotoxicity against mouse osteoblast cells by alamar blue assay
Cytotoxicity against mouse osteoblast cells by alamar blue assay
|
[PMID: 20692834] |
| Osteoclast | IC50 |
1.3 μM
Compound: 3u
|
Cytotoxicity against mouse osteoclast cells expressing RANKL signaling by Alamar blue assay
Cytotoxicity against mouse osteoclast cells expressing RANKL signaling by Alamar blue assay
|
[PMID: 20692834] |
Chemical Information
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CAS No. 1117772-52-7
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Molecular Weight 320.37
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Formula C19H22F2O2
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SMILES
OC(CCCCCO)C1=CC=C(C(C)=C1)C2=CC=C(C=C2F)F
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)