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Cat. No.: HY-152109

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AChE/MAO-IN-1

AChE/MAO-IN-1 (Compound D28) is a potent AChE, MAO-A and MAO-B inhibitor with IC₅₀s of 0.0248, 0.0409 and 0.1108 μM against human AChE, MAO-B and MAO-A, respectively.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₂₃H₂₆N₂O₃
Masse moléculaire:378.46

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

AChE/MAO-IN-1 Chemical Structure

Stock

Quantité

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

AChE/MAO-IN-1 (Compound D28) is a potent AChE, MAO-A and MAO-B inhibitor with IC₅₀s of 0.0248, 0.0409 and 0.1108 μM against human AChE, MAO-B and MAO-A, respectively^[1].

IC₅₀ & Target

^[1]

hAChE

0.0248 μM (IC₅₀)

hMAO-B

0.0409 μM (IC₅₀)

hMAO-A

0.1069 μM (Ki)

hMAO-A

0.1108 μM (IC₅₀)

Aβ42

0.1467 μM (IC₅₀)

Voir tous les produits spécifiques à Isoform Cholinesterase (ChE) :

AChE
BChE

Voir tous les produits spécifiques à Isoform Monoamine Oxidase :

MAO-A
MAO-B

In Vitro

AChE/MAO-IN-1 (Compound D28) shows antioxidant activity with an IC₅₀ of 0.210 ± 0.010 μM in the DPPH free-radical scavenging activity test^[1].
AChE/MAO-IN-1 inhibits beta amyloid 1–42 (Aβ42) with an IC₅₀ of 0.1467 ± 0.0053 μM^[1].
AChE/MAO-IN-1 (24 h) shows low cytotoxicity against NIH/3T3 cells (IC₅₀: 6.5162 ± 0.1750 μM)^[1].
AChE/MAO-IN-1 can very effectively bind to the active site of the MAO-A enzyme^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

NIH/3T3 mouse fibroblast healthy cell line
Concentration:
Incubation Time:

24 h
Result:

Showed cytotoxicity with an IC₅₀ of 6.5162 ± 0.1750 μM.

Chemical Information

Masse moléculaire 378.46
Formule C₂₃H₂₆N₂O₃
SMILES

O=C(NC1=CC=C(/C=C(CC2=C3C=CC(OC)=C2)\C3=O)C=C1)CN(C)CCC
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Sağlık BN, et al. Design, Synthesis, and In Vitro and In Silico Approaches of Novel Indanone Derivatives as Multifunctional Anti-Alzheimer Agents. ACS Omega. 2022 Dec 7;7(50):47378-47404. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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AChE/MAO-IN-1

Voir tous les produits spécifiques à Isoform Cholinesterase (ChE)

Voir tous les produits spécifiques à Isoform Monoamine Oxidase

Activité biologique

Description

IC50 & Target

In Vitro

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

AChE/MAO-IN-1 Related Classifications

HY-152109 Related Classifications

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