AChE/MAO-IN-1

Cat. No.: HY-152109: FAQs
Data Sheet Handling Instructions

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AChE/MAO-IN-1 (Compound D28) is a potent AChE, MAO-A and MAO-B inhibitor with IC₅₀s of 0.0248, 0.0409 and 0.1108 μM against human AChE, MAO-B and MAO-A, respectively.

For research use only. We do not sell to patients.

AChE/MAO-IN-1 Chemical Structure

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Biological Activity
Purity & Documentation
References
Customer Review

Description

AChE/MAO-IN-1 (Compound D28) is a potent AChE, MAO-A and MAO-B inhibitor with IC₅₀s of 0.0248, 0.0409 and 0.1108 μM against human AChE, MAO-B and MAO-A, respectively^[1].

IC₅₀ & Target^[1]

hAChE

0.0248 μM (IC₅₀)

hMAO-B

0.0409 μM (IC₅₀)

hMAO-A

0.1069 μM (Ki)

hMAO-A

0.1108 μM (IC₅₀)

Aβ42

0.1467 μM (IC₅₀)

In Vitro

AChE/MAO-IN-1 (Compound D28) shows antioxidant activity with an IC₅₀ of 0.210 ± 0.010 μM in the DPPH free-radical scavenging activity test^[1].
AChE/MAO-IN-1 inhibits beta amyloid 1–42 (Aβ42) with an IC₅₀ of 0.1467 ± 0.0053 μM^[1].
AChE/MAO-IN-1 (24 h) shows low cytotoxicity against NIH/3T3 cells (IC₅₀: 6.5162 ± 0.1750 μM)^[1].
AChE/MAO-IN-1 can very effectively bind to the active site of the MAO-A enzyme^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:	NIH/3T3 mouse fibroblast healthy cell line
Concentration:
Incubation Time:	24 h
Result:	Showed cytotoxicity with an IC₅₀ of 6.5162 ± 0.1750 μM.

Molecular Weight

378.46

Formula

C₂₃H₂₆N₂O₃

SMILES

O=C(NC1=CC=C(/C=C(CC2=C3C=CC(OC)=C2)\C3=O)C=C1)CN(C)CCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sağlık BN, et al. Design, Synthesis, and In Vitro and In Silico Approaches of Novel Indanone Derivatives as Multifunctional Anti-Alzheimer Agents. ACS Omega. 2022 Dec 7;7(50):47378-47404. [Content Brief]

AChE/MAO-IN-1 Related Classifications

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Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AChE/MAO-IN-1Cholinesterase (ChE)Monoamine OxidaseAmyloid-βMAOβ-amyloid peptideAβAbetaantioxidantAlzheimer’s diseaselow cytotoxicityInhibitorinhibitorinhibit

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