AChE/MAO-IN-1
AChE/MAO-IN-1 (Compound D28) is a potent AChE, MAO-A and MAO-B inhibitor with IC50s of 0.0248, 0.0409 and 0.1108 μM against human AChE, MAO-B and MAO-A, respectively.
For research use only. We do not sell to patients.
- Formula: C23H26N2O3
- Molecular Weight:378.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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hAChE 0.0248 μM (IC50) |
hMAO-B 0.0409 μM (IC50) |
hMAO-A 0.1069 μM (Ki) |
hMAO-A 0.1108 μM (IC50) |
Aβ42 0.1467 μM (IC50) |
AChE/MAO-IN-1 (Compound D28) shows antioxidant activity with an IC50 of 0.210 ± 0.010 μM in the DPPH free-radical scavenging activity test[1].
AChE/MAO-IN-1 inhibits beta amyloid 1–42 (Aβ42) with an IC50 of 0.1467 ± 0.0053 μM[1].
AChE/MAO-IN-1 (24 h) shows low cytotoxicity against NIH/3T3 cells (IC50: 6.5162 ± 0.1750 μM)[1].
AChE/MAO-IN-1 can very effectively bind to the active site of the MAO-A enzyme[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:NIH/3T3 mouse fibroblast healthy cell line
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Concentration:
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Incubation Time:24 h
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Result:Showed cytotoxicity with an IC50 of 6.5162 ± 0.1750 μM.
Chemical Information
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Molecular Weight 378.46
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Formula C23H26N2O3
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SMILES
O=C(NC1=CC=C(/C=C(CC2=C3C=CC(OC)=C2)\C3=O)C=C1)CN(C)CCC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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