Adhesamine
Based on 1 publication(s) in Google Scholar
Adhesamine, dumbbell-shaped molecule, activates MAPK/FAK pathway. Adhesamine promotes adhesion and growth of mammalian cells. Adhesamine accelerates the differentiation and improves the survival of mice hippocampal neurons in primary culture.
For research use only. We do not sell to patients.
- Purity : 99.46%
- CAS No.: 462605-73-8
- Formula: C24H32Cl4N8O2S2
- Molecular Weight:670.51
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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HY-12444
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HY-132296
GSK215PROTAC FAK Degrader -
HY-111546
BI-3663PROTAC PTK2/FAK Degrader -
HY-103471
Y11FAK1 Inhibitor -
HY-19376
NAMI-ARuthenium Anticancer Agent -
HY-148109
FAK-IN-7FAK Inhibitor -
HY-12289
DefactinibFAK Inhibitor -
HY-126410R
Petunidin chloride (Standard)Focal Adhesion Kinase Inhibitor -
HY-12289AR
Defactinib hydrochloride (Standard)FAK Inhibitor -
HY-122844
IfebemtinibFAK Inhibitor
Publications Citing Use of MedChemExpress (MCE) Adhesamine
More
Biological Activity
Description
IC50 & Target
MAPK/FAK[1]
In Vitro
Adhesamine (20 μg/mL; 0-30 d) facilitates attachment and enhances survival of mouse primary cultured hippocampal neurons. Adhesamine induces neurite branching and rapid differentiation of mouse primary cultured hippocampal neurons[1].
Adhesamine (20 μg/mL; 1 d, 3 d, 4 d) induces cell adhesion by cell-surface heparan sulfate and activates FAK phosphorylation. Adhesamine stimulates neurite differentiation through MAPK activation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 462605-73-8
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Appearance Solid
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Molecular Weight 670.51
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Formula C24H32Cl4N8O2S2
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Color Off-white to light yellow
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SMILES
O=CC1=C(N=C(SC)N=C1N2CC[N+]3(CC[N+]4(CC3)CCN(CC4)C5=NC(SC)=NC(Cl)=C5C=O)CC2)Cl.[Cl-].[Cl-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
In Vitro:
DMSO : 1 mg/mL (1.49 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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Primary Embryonic Hippocampal Neuron Culture
Primary embryonic hippocampal neuron culture is an in vitro method in which hippocampi from embryonic rodents are dissected, enzymatically or mechanically dissociated, plated on adhesive substrates, and maintained in defined neuronal medium or in low-density sandwich/co-culture formats to support neuronal attachment, neurite extension, polarity formation, dendritic arborization, and synapse formation. The main readouts are cell survival, neuronal purity, neurite outgrowth, axon-dendrite polarization, synaptic marker development, and functional neuronal activity, assessed by phase-contrast microscopy, immunocytochemistry for neuronal/glial markers, live imaging, or electrophysiology depending on the downstream experiment.
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4914 mL | 7.4570 mL | 14.9140 mL | 37.2851 mL |
Adhesamine Related Classifications
HY-122672 Related Classifications
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