Adhesamine 

Adhesamine, dumbbell-shaped molecule, activates MAPK/FAK pathway. Adhesamine promotes adhesion and growth of mammalian cells. Adhesamine accelerates the differentiation and improves the survival of mice hippocampal neurons in primary culture^[1].

MAPK/FAK^[1]

Adhesamine (20 μg/mL; 0-30 d) facilitates attachment and enhances survival of mouse primary cultured hippocampal neurons. Adhesamine induces neurite branching and rapid differentiation of mouse primary cultured hippocampal neurons^[1].
Adhesamine (20 μg/mL; 1 d, 3 d, 4 d) induces cell adhesion by cell-surface heparan sulfate and activates FAK phosphorylation. Adhesamine stimulates neurite differentiation through MAPK activation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

670.51

C₂₄H₃₂Cl₄N₈O₂S₂

462605-73-8

Solid

Off-white to light yellow

O=CC1=C(N=C(SC)N=C1N2CC[N+]3(CC[N+]4(CC3)CCN(CC4)C5=NC(SC)=NC(Cl)=C5C=O)CC2)Cl.[Cl-].[Cl-]

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Hoshino M, et al. Adhesamine, a new synthetic molecule, accelerates differentiation and prolongs survival of primary cultured mouse hippocampal neurons. Biochem J. 2010 Mar 29;427(2):297-304.  [Content Brief]