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Cat. No.: HY-178203

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AM12814

AM12814 is a potent and partial CB1 and CB2 agonist with K_i values of 0.7 nM and 3.4 nM. AM12814 can inhibit cAMP accumulation and recruitse β-arrestin 2. AM12814 exhibits cannabimimetic effects. AM12814 can be used for the research of neurological disease, suah as catalepsy.

For research use only. We do not sell to patients.

CAS No.: 3054511-18-8
Formula: C₂₄H₃₈F₃NO₂
Molecular Weight:429.56

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

AM12814 Chemical Structure

CAS No.: 3054511-18-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

rCB1-R

0.7 nM (Ki)

hCB2-R

3.4 nM (Ki)

All Cannabinoid Receptor Isoforms :

In Vitro

AM12814 (Compound 12) binds to cannabinoid receptors with high affinity, with K_i values of 0.7 nM (rCB1) and 3.4 nM (hCB2)^[1].
AM12814 (30 mins) inhibits Forskolin (HY-15371)-stimulated cAMP accumulation in 3xHA-hCB1-CHO and 3xHA-hCB2-CHO cells with EC₅₀ values of 8.75 nM and 22 nM^[1].
AM12814 (90 mins) recruitses β-arrestin 2 in hCB1-DRx-CHO and hCB2-DRx-U2OS cells with EC₅₀ values of 25 nM and 5.6 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AM12814 (Compound 12) (0.3-3 mg/kg, i.p.) induces CB1-mediated cannabimimetic behaviors in CD1 mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

CD1 mice^[1]
Dosage:

0.3, 1 and 3 mg/kg
Administration:

Intraperitoneally injection
Result:

Increased immobility time in the ring test.
Reduced core body temperature.
Prolonged tail-flick latency in the hot water test.
Alleviated CFA (HY-153808)-induced mechanical hypersensitivity.

Chemical Information

CAS No. 3054511-18-8
Molecular Weight 429.56
Formula C₂₄H₃₈F₃NO₂
SMILES

O=C(N[C@H](C)CO)CCC/C=C\C/C=C\C/C=C\[C@@H](C)/C=C\CCCCC(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Georgiadis MO, et al. Exceptionally Potent Chiral Anandamide Analogs. J Med Chem. 2025 Sep 15. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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