2. NF-κB Apoptosis Immunology/Inflammation
  3. TNF Receptor Interleukin Related NF-κB NO Synthase
  4. Anti-inflammatory agent 54

Anti-inflammatory agent 54 (compound 9c) is a derivative of Coixol and has anti-inflammatory activity. Anti-inflammatory agent 54 inhibits the NF-κB pathway and downregulates the expression of iNOS, TNF-α, IL-6 and IL-1β. Anti-inflammatory agent 54 inhibits LPS-induced nitric oxide (NO) production in RAW264.7 macrophages (IC50: 2.4 μM) and exerts in vivo anti-inflammatory activity in a mouse auricular edema model.

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Anti-inflammatory agent 54

Anti-inflammatory agent 54 Estructura química

No. CAS : 2924156-46-5

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Anti-inflammatory agent 54 Related Antibodies

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nNOS iNOS eNOS

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Descripciòn

Anti-inflammatory agent 54 (compound 9c) is a derivative of Coixol and has anti-inflammatory activity. Anti-inflammatory agent 54 inhibits the NF-κB pathway and downregulates the expression of iNOS, TNF-α, IL-6 and IL-1β. Anti-inflammatory agent 54 inhibits LPS-induced nitric oxide (NO) production in RAW264.7 macrophages (IC50: 2.4 μM) and exerts in vivo anti-inflammatory activity in a mouse auricular edema model[1].

Cellular Effect
Cell Line Type Value Description References
RAW264.7 IC50
>100 μM
Compound: 9c
Cytotoxicity against mouse RAW264.7 cells incubated for 24 hrs by MTT assay
Cytotoxicity against mouse RAW264.7 cells incubated for 24 hrs by MTT assay
[PMID: 37561816]
RAW264.7 IC50
11.6 μM
Compound: 9c
Inhibition of IL-1beta production in LPS-induced mouse RAW264.7 cells pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs by ELISA
Inhibition of IL-1beta production in LPS-induced mouse RAW264.7 cells pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs by ELISA
[PMID: 37561816]
RAW264.7 IC50
2.4 μM
Compound: 9c
Antiinflammatory activity in LPS-induced mouse RAW264.7 cells assessed as inhibition of NO production pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs by griess reagent based assay
Antiinflammatory activity in LPS-induced mouse RAW264.7 cells assessed as inhibition of NO production pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs by griess reagent based assay
[PMID: 37561816]
RAW264.7 IC50
7.5 μM
Compound: 9c
Inhibition of TNF-alpha production in LPS-induced mouse RAW264.7 cells pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs by ELISA
Inhibition of TNF-alpha production in LPS-induced mouse RAW264.7 cells pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs by ELISA
[PMID: 37561816]
RAW264.7 IC50
8.8 μM
Compound: 9c
Inhibition of IL-6 production in LPS-induced mouse RAW264.7 cells pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs by ELISA
Inhibition of IL-6 production in LPS-induced mouse RAW264.7 cells pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs by ELISA
[PMID: 37561816]
Peso molecular

328.32

Fòrmula

C17H16N2O5
No. CAS
SMILES

O=C(/C=C/C1=CC=CO1)NCCN2C3=CC=C(OC)C=C3OC2=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
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Anti-inflammatory agent 54 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-inflammatory agent 542924156-46-5TNF ReceptorInterleukin RelatedNF-κBNO SynthaseTumor Necrosis Factor ReceptorTNFRILNuclear factor-κBNuclear factor-kappaBNitric oxide synthasesNOSAnti-inflammatory activityiNOSTNF-αIL-6IL-1βRAW264.7 macrophagesmouse auricle edema modelInhibitorinhibitorinhibit

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Anti-inflammatory agent 54
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HY-155820
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