Anti-MRSA agent 28
Anti-MRSA agent 28 is an antibacterial agent against multidrug resistant (MDR) gram-positive strains with MICs of 0.06-0.125 μg/mL. Anti-MRSA agent 28 can target DNA polymerase IIIC to reduce the amount of genomic DNA with the IC50 of 3.80 μg/mL. Anti-MRSA agent 28 has good antibacterial activity and reduces inflammation. Anti-MRSA agent 28 can be used against gram-positive strains and infectious conditions.
For research use only. We do not sell to patients.
- CAS No.: 2222727-47-9
- Formula: C27H22ClN3O5
- Molecular Weight:503.93
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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DNA Polymerase |
Anti-MRSA agent 28 (Compound 5a) shows antibacterial activity against the Gram-positive strains, including S. aureus ATCC 33591 (MIC = 0.125 μg/mL), ATCC 700698 (MIC = 0.125 μg/mL), ATCC 700699 (MIC = 0.06 μg/mL) and ATCC BAA1708 (MIC = 0.125 μg/mL) [1].
Anti-MRSA agent 28 (0.25 μg/mL-4 μg/mL; 0 h-24 h) has antibacterial activity against S. aureus ATCC 33591[1].
Anti-MRSA agent 28 (1 μg/mL; 1 h) might inhibit the dysfunction of genomic DNA[1].
Anti-MRSA agent 28 (0.5 μg/mL-4.5 μg/mL) effectively influence the quantity of genomic DNA[1].
Anti-MRSA agent 28 (6.25 μM-50 μM) can dose-dependently bond to immobilized DNA Pol IIIC with the KD of 8.45 μM[1].
Anti-MRSA agent 28 (0 μg/mL-16 μg/mL) inhibits the DNA Pol IIIC of S. aureus ATCC 33591[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:The infection model was constructed by adding a droplet (20 μL) of 9 lg10 CFU/mL of S. aureus ATCC 33591 on the wound surface of the female BALB/c mouse (8 weeks)[1].
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Dosage:2 % in vaseline
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Administration:Apply medication
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Result:Significantly lowered serum levels of pro-inflammatory cytokines: interleukin IL-1β, IL-6, TNF-α and C-reactive protein and effectively alleviated the necrosis.
Chemical Information
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CAS No. 2222727-47-9
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Molecular Weight 503.93
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Formula C27H22ClN3O5
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SMILES
COC1=C(C2=C(C3=C4C5=C(C6=C(OCO6)C=C5CC[N+]4=C2)C=C3)C=C1)OC(C7=CC(C)=NN7C)=O.[Cl-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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