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Cat. No.: HY-187128

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Antibacterial agent 362

Antibacterial agent 362 is a broad-spectrum antibacterial agent. Antibacterial agent 362 exhibits broad-spectrum inhibitory activity against a variety of mycobacteria and Staphylococcus aureus, with a MIC₅₀ of 235 μM against M. tuberculosis, while it shows no activity against Escherichia coli. Antibacterial agent 362 can be used in research related to tuberculosis and mycobacterial infections.

For research use only. We do not sell to patients.

CAS No.: 562817-22-5
Formula: C₁₁H₁₁ClN₂O
Molecular Weight:222.67

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Antibacterial agent 362 Chemical Structure

CAS No.: 562817-22-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
THP-1	CC₅₀	345 μM	Cytotoxicity against human differentiated THP-1 monocytic cells assessed via cell viability proliferation assay after 24 h incubation. Cytotoxicity against human differentiated THP-1 monocytic cells assessed via cell viability proliferation assay after 24 h incubation.	29229639
HepG2	CC₅₀	676 μM	Cytotoxicity against human HepG2 hepatocyte cells assessed via cell viability proliferation assay after 24 h incubation. Cytotoxicity against human HepG2 hepatocyte cells assessed via cell viability proliferation assay after 24 h incubation.	29229639

In Vitro

Antibacterial agent 362 (F15) (1-1000 μM; variable incubation times) inhibits growth of Mycobacterium tuberculosis H37Rv with an MIC₅₀ of 235 μM, shows broad activity against other mycobacteria and Staphylococcus aureus, and has moderate selectivity over human cells and red blood cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 562817-22-5
Molecular Weight 222.67
Formula C₁₁H₁₁ClN₂O
SMILES

ClC1=CC=C(C=C1)OC2=C(C)NN=C2C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Negatu DA, et al. Whole-Cell Screen of Fragment Library Identifies Gut Microbiota Metabolite Indole Propionic Acid as Antitubercular. Antimicrobial agents and chemotherapy. 2018 Mar;62(3):e01571-17.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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