Anticancer agent 110 

Anticancer agent 110 is an anticancer agent with in vitro anticancer activity and excellent anti-leukemia potency. Anticancer agent 110 is highly cytotoxic to K-562 lineage chronic myelogenous leukemia cells at nanomolar concentrations. Anticancer agent 110 causes DNA damage and leads to apoptosis^[1].

Anticancer agent 110 (compound 3d) (0.01 μM-100 μM) inhibits leukemia K-562 cells with IC₅₀ of 0.7 μM^[1].
Anticancer agent 110 (70 nM, 700 nM; 24 h) causes a higher level of DNA damage in K-562 cells^[1].
Anticancer agent 110 (70 nM, 700 nM; 24 h) induces pro-apoptotic changes in the morphology of leukemia cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

380.40

C₁₈H₁₃FN₆OS

887349-03-3

O=C(C1=CC=C(N2N=NN=C2)C=C1)NC3=NC=C(CC4=CC=C(C=C4)F)S3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Pokhodylo N, et al. Bioisosteric replacement of 1H-1,2,3-triazole with 1H-tetrazole ring enhances anti-leukemic activity of (5-benzylthiazol-2-yl)benzamides. Eur J Med Chem. 2023 Mar 15;250:115126.  [Content Brief]