2. Cell Cycle/DNA Damage
  3. Haspin Kinase
  4. Anticancer agent 285

Anticancer agent 285 is an orally active anticancer agent with highly effective and selective haspin-inhibiting IC50 = 18 nM) activity. Anticancer agent 285 can be used for the study of colorectal cancer[1].

For research use only. We do not sell to patients.

Anticancer agent 285

Anticancer agent 285 Chemical Structure

CAS No. : 2878446-03-6

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Anticancer agent 285 Related Antibodies

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Description

Anticancer agent 285 is an orally active anticancer agent with highly effective and selective haspin-inhibiting IC50 = 18 nM) activity. Anticancer agent 285 can be used for the study of colorectal cancer[1].

IC50 & Target

haspin

18 nM (IC50)

In Vitro

Anticancer agent 285 (Compound 1d) (72 h) exhibits IC50 values of 3.31 μM in SK-Hep-1 cells, 3.91 μM in MDA-MB-231 cells, 4.82 μM in HCT116 cells, 19.7 μM in A549 cells, and 3.58 μM in SNU-638 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 285 Related Antibodies
In Vivo

Anticancer agent 285 (Compound 1d) (10 mg/kg, p.o./i.p., three times per week for 23 days) significantly inhibits tumor growth in a human colorectal cancer cell line (HCT116 cells) xenograft mouse model without showing significant toxicity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HCT116 cells (7 × 106 cells per mouse) were injected subcutaneously into the flanks of the Male Balb/c-nu mice (male, aged 4 weeks)[1].
Dosage: 10 mg/kg
Administration: P.o., i.p., three times per week for 23 days
Result: The oral administration resulted in a tumor inhibition rate of 51.7%.
The intraperitoneal injection resulted in a tumor inhibition rate of 46.2%.
No significant weight loss or obvious toxicity symptoms were observed in any of the mice.
Molecular Weight

306.34

Formula

C12H14N6O2S
CAS No.
SMILES

O[C@@H]1[C@H](O)[C@@H](CN)S[C@H]1N(C2=C3C(N)=NC=N2)C=C3C#N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anticancer agent 285 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 2852878446-03-6Anticancer agent285Anticancer agent-285Haspin KinaseThionucleosidesMitotic kinaseHaspinKinase inhibitorAnticancer agentColorectal cancerMolecular modelingInhibitorinhibitorinhibit

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