1. Apoptosis
  2. Apoptosis
  3. Anticancer agent 44

Anticancer agent 44 

Cat. No.: HY-146286
Handling Instructions

Anticancer agent 44 (compound 2a) is a potent anticancer agent. Anticancer agent 44 shows cytotoxicity activity in cancer cells. Anticancer agent 44 induces apoptosis. Anticancer agent 44 shows low toxicity towards activated lymphocytes of human blood.

For research use only. We do not sell to patients.

Anticancer agent 44 Chemical Structure

Anticancer agent 44 Chemical Structure

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Description

Anticancer agent 44 (compound 2a) is a potent anticancer agent. Anticancer agent 44 shows cytotoxicity activity in cancer cells. Anticancer agent 44 induces apoptosis. Anticancer agent 44 shows low toxicity towards activated lymphocytes of human blood[1].

In Vitro

Anticancer agent 44 (compound 2a) (0-100 µM; 72 h) shows antitumor activity with GI50s of 3.40, 63.90, 7.95, 6.45, 70.30, 6.65, 9.18, 6.00, 8.93, 65.90, >100 µM for Jurkat, A549, MCF-7, MDA-MB-231, KB3-1, HeLa, HCT-116, HCT-116 p53-/-, U251, SK-OV-3, HaCaT cells, respectively[1].
Anticancer agent 44 (1.5 µM; 24 h) induces apoptosis by increases the expression of caspase 3, Bax and decreases the amount of anti-apoptotic Bcl-2 protein[1].
Anticancer agent 44 (0-2 µM; 24, 48 h) shows low toxicity towards normal human keratinocytes of HaCaT line and mitogen-activated lymphocytes of peripheral blood of healthy human donor[1].
Anticancer agent 44 dose not induce significant DNA damage and changes in morphology of mitogen-activated lymphocytes of peripheral blood of healthy donor[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

534.39

Formula

C22H13Cl2N3O5S2

SMILES

O=C1CC(C(N1C2=CC=C(C=C2)Cl)=O)N3C(/C(SC3=S)=C/C(Cl)=C/C4=CC=C(C=C4)[N+]([O-])=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Anticancer agent 44
Cat. No.:
HY-146286
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