2. Apoptosis
  3. Apoptosis
  4. Anticancer agent 99

Anticancer agent 99 (compound 2p) has good anticancer activity against HepG2 cells, with an IC50 value of 35.9 μM. Anticancer agent 99 can induce apoptosis and has anti-proliferation effect.

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Anticancer agent 99 Chemical Structure

Anticancer agent 99 Chemical Structure

CAS No. : 2914922-83-9

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Description

Anticancer agent 99 (compound 2p) has good anticancer activity against HepG2 cells, with an IC50 value of 35.9 μM. Anticancer agent 99 can induce apoptosis and has anti-proliferation effect[1].

In Vitro

Anticancer agent 99 (0-50 μM, 24 h) directly upregulates Bax expression and induces caspase-3-dependent apoptosis in HepG2 cell line, with antiproliferative effects[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 99 Related Antibodies

Apoptosis Analysis[1]

Cell Line: HepG2 cell
Concentration: 25, 50 μM
Incubation Time: 24 h
Result: Increased mRNA transcript levels of pro-apoptotic Bax and Caspase-3 genes.
Reduced Akt protein levels in HepG2 cells.
Increased FoXO1, TXNIP and p27 protein levels in HepG2 cells.
Molecular Weight

379.38

Formula

C19H20F3N3O2
CAS No.
SMILES

O=C(C1=CC=C(NCCCC)C=C1)N/N=C/C2=C(OC(F)(F)F)C=CC=C2
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References
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Anticancer agent 99 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 992914922-83-9Anticancer agent99Anticancer agent-99ApoptosisHepG2anticancerapoptosisanti-proliferationInhibitorinhibitorinhibit

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